Glotadol 325 Abbott medicine supports antipyretic and analgesic (200 tablets)

Dosage form Film bag tablets
Specifications Bottle of 200 capsules
Ingredient Paracetamol

Ingredient

Composition information	Content
Paracetamol	325mg

Uses

Indications

Glotadol 325 mg is indicated in the following cases:

Reduce fever. The drug is not effective for treating inflammation. Paracetamol relieves pain by increasing pain and cooling down through impact on the center of the thermostat in the hypothalamus, without causing stomach irritation.

Paracetamol is usually a painkiller or antipyretics, especially in the elderly and in patients not prescribed Salicylate or other nonsteroidal anti -inflammatory drugs. These patients include people with asthma, people with a history of digestive ulcers and children.

pharmacokinetic

absorption

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. The peak concentration of plasma is within 30 - 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed mostly in the body's tissues. About 25% of the drug is attached to plasma proteins. Paracetamol passes the placenta and is distributed in breast milk.

Metabolism

Paracetamol is n - hydroxylated by cytochrome P450 to create N - Acetyl - Benzoquinonimin, an intermediary with high reaction. This metabolites normally react with sulfhydryl groups in glutathion. However, if taking high doses of paracetamol, this metabolic is made up, exhausting the glutathion of the liver; Its reaction to liver protein increases, which can lead to liver necrosis.

Elimination

Paracetamol's semi -discharged time is 1.25 - 3 hours, can be prolonged with toxic doses or in patients with liver damage.

After the treatment dose, 90 - 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); It also detects a small amount of hydroxyl metabolites - chemicals and reducing acetyl. Children are less likely to match Glucuronid with drugs than adults.

Before taking Glotadol 325 Abbott medicine supports antipyretic and analgesic (200 tablets)

How to use

oral drugs

Dosage

Adults and children over 12 years old

Take 2 tablets/time, the distance between the medication from 4-6 hours, no more than 12 tablets/day.

Children from 6 to 12 years old

Take 1 capsule/time, the distance between drinking from 4-6 hours, no more than 6 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Nausea, vomiting, abdominal pain and pale often appear in the first 1 hour. Overdose of 10 g or more (150 mg/kg of weight in children) can cause liver cell destruction, leading to complete and non -recovery liver necrosis; Metabolic acidosis and brain disease can lead to coma and death. In addition, the concentration of aminotransferase and plasma bilirubin increases, the long prothrombin time can appear after 12 - 48 hours.

Handling

Gastrointestinal or drinking carbon to eliminate the medication immediately taken. Intravenous injection or n - acetylcystein oral oral (Paracetamol's specific antidote), most effective is before the 10th hour after overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Glotadol 325 mg, you may experience unwanted effects (ADR).

Side effects are usually mild and can recover after stopping the drug.

Uncommon, 1/1000

Skin: rash, erythema or urticaria.

stomach - intestines: nausea, vomiting.

Hematology: neutropenia, leukopenia, hypocpturia, anemia.

kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare, ADR

Body: Hypersensitivity reaction.

Instructions on how to handle ADR

If there is an abnormal new sign, symptoms do not improve after 7 days or have fever, stop using and consult a doctor.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Glotadol 325 mg is contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Patients with glucose deficiency - 6 - phosphate dehydrogenase (G6PD).

Patients with severe hepatitis, severe liver failure.

Precautions when using

Do not use with other drugs containing paracetamol.

Do not use paracetamol to treat pain relief for more than 10 days in adults or more than 5 days in children without a doctor's instructions.

Be cautious when used in patients with weakened liver or kidney function.

Precautions for patients with a history of anemia.

Should avoid or limit alcohol when taking the drug as alcohol can increase the toxicity of paracetamol in the liver.

Doctors need to warn patients on signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug does not adversely affect the ability to drive and use machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may be available to the fetus. Therefore, this medication should only be used for pregnant women when really necessary.

Breastfeeding period

There is no unwanted effect in breastfeeding when a mother uses paracetamol, so the drug can be used during breastfeeding.

Drug interaction

long -term oral doses with high doses of paracetamol may increase the effect of anticoagulant drugs such as Coumarin or Indandion derivatives.

Simultaneous use of paracetamol and phenothiazine can cause serious fever.

Out of too much and long -term alcohol can increase the risk of paracetamol toxicity in the liver.

The risk of toxicity of paracetamol toxicity on the liver increases when using high -dose paracetamol and prolonged while taking enzyme induction drugs in the liver microsom such as isoniazid or anti -convulsions (including phenytoin, barbiturate, carbamazepine). The excretion of paracetamol may be affected and the plasma paracetamol levels may change when used with probenecid.

Colestyramin reduces paracetamol absorption if used within 1 hour before or after taking paracetamol.

Storage

Leave in a dry place, avoid light, the temperature does not exceed 30 ° C.

Other drugs

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