Glotadol 500 Abbott supports antipyretic and analgesic (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Paracetamol

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

Indications

Glotadol 500mg drug is indicated in the following cases:

A reduction of fever.

Relieve mild to moderate pain such as headache and common muscle aches, flu aches or colds, back pain, toothache, pain due to mild arthritis and menstrual pain.

Pharmacokological

Paracetamol, a para-aminophenol derivative, has an antipyretic and analgesic effect. The drug is not effective for treating inflammation. Paracetamol relieves pain by increasing pain and cooling down through impact on the center of the thermostat in the hypothalamus, without causing stomach irritation.

Paracetamol is usually a painkiller or antipyretics, especially in the elderly and in patients not prescribed Salicylate or other nonsteroidal anti -inflammatory drugs. These patients include people with asthma, people with a history of digestive ulcers, and children.

pharmacokinetic

absorption

Paracetamol is absorbed quickly and almost entirely through the gastrointestinal tract. Foods can cause long -lasting release pellets to be slowly absorbed in paracetamol. Carbohydrate -rich foods reduce the absorption rate of paracetamol. The peak concentration of plasma is within 30 - 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Elimination

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage. After the treatment dose, 90 - 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); Small amounts of hydroxyl metabolites are found - chemical and reducing acetyl. Children are less likely to glucuro than drugs than adults.

Paracetamol is n-hydroxylation by cytochrom P450 to create N-acetyl-Benzoquinonimin (NAPQI), an intermediate reactive intermediate. This metabolic substance normally reacts with sulfhydryl groups in glutathion and is dimidated. However, if taking high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver; In that situation, Napqi is not connected with glutathion toxic to liver cells, leading to inflammation and can lead to liver necrosis.

Before taking Glotadol 500 Abbott supports antipyretic and analgesic (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults and children over 12 years old

Take 1 tablet/time, the distance between the medication from 4 - 6 hours, no more than 6 tablets/day.

Children from 6 to 12 years old

Take 1/2 tablets/time, the distance between the medication from 4 - 6 hours, no more than 3 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Nausea, vomiting, abdominal pain and pale often appear in the first hour. Overdose of 10 g or more (150mg/kg of weight in children) can cause liver cell destruction, leading to complete and non -recovery liver necrosis; Metabolic acidosis and brain disease can lead to coma and death. In addition, the concentration of aminotransferase and plasma bilirubin increases, the long prothrombin time can appear after 12 - 48 hours.

Handling

Gastrointestinal or drinking carbon to eliminate the medication immediately taken. Intravenous injection or n-acetylcysteine oral oral, distinctive antidote of paracetamol, most effectively is before the 10th hour after overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Glotadol 500mg, you may experience unwanted effects (ADR).

Side effects are usually mild and can recover after stopping the drug.

Uncommon, 1/1000

On the skin: rash, erythema or urticaria.

Stomach - intestines: Nausea, vomiting.

Hematology: neutropenia, leukopenia, all bloody, anemia.

Kidney: Kidney disease, kidney toxicity when abusing for a long time.

Rare, ADR

Skin: Hypersensitivity reaction.

Instructions on how to handle ADR

Stop using and consulting your doctor if there is an abnormal new sign, symptoms do not improve after 7 days or with fever.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Glotadol 500mg contraindications in the following cases:

Hypersensitivity to the ingredients of the drug.

Patients with glucose-6-phosphate dehydrogenase deficiency.

Hepatitis progressed severe, severe liver failure.

Patients with many times anemia.

Precautions when using

Do not use with other drugs containing paracetamol.

Paracetamol is relatively non -toxic at the dose of treatment. Sometimes there are skin reactions including rugged rash and urticaria; Other sensitive reactions include larynx edema, angioedema, and anaphylactic reactions that may rarely occur. Platelets, leukopenia, and all bloody hematuria have occurred with the use of p - aminophenol derivatives, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Do not use paracetamol to treat pain relief for more than 10 days in adults or more than 5 days in children without a doctor's instructions.

Be cautious when used in patients with weakened liver or kidney function.

Precautions for patients with a history of anemia.

Should avoid or limit alcohol when taking the drug as alcohol can increase the toxicity of paracetamol in the liver.

Doctors need to warn the patient about signs of serious skin reactions such as Steven - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug does not adversely affect the ability to drive and use machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may be available to the fetus. Therefore, this medication should only be used for pregnant women when really necessary.

Breastfeeding period

There is no unwanted effect in breastfeeding when a mother uses paracetamol, and so the drug can be used during breastfeeding.

Drug interaction

long -term oral doses with high doses of paracetamol may increase the effect of anticoagulant drugs such as Coumarin or Indandion derivatives.

Simultaneous use of paracetamol and phenothiazine can cause serious fever.

Out of too much and long -term alcohol can increase the risk of paracetamol toxicity in the liver.

The risk of toxicity of paracetamol on the liver increases when using high -dose and prolonged paracetamol while taking enzyme induction drugs in the liver microsom such as isoniazid or anti -convulsions (including phenytoin, barbiturate, carbamazepine).

The excretion of paracetamol may be affected and the plasma paracetamol levels may change when used with probenecid.

cholestyramin reduces paracetamol absorption if used within 1 hour before or after taking paracetamol.

Storage

Leave in a dry place, avoid light, the temperature does not exceed 30 ° C.

Other drugs

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