Glotadol 650 Abbott medicine supports antipyretic and analgesic (200 tablets)

Dosage form Film bag tablets
Specifications Box of 200 tablets
Ingredient Acetaminophen

Ingredient

Composition information	Content
Acetaminophen	650mg

Uses

Indications

Glotadol 650 pills are indicated in the following cases:

Fever.

Reduce mild to medium pain such as headache and common muscle pain, flu aches or colds, back pain, toothache, pain due to mild arthritis and menstrual pain. The drug is not effective for treating inflammation.

Paracetamol relieves pain by increasing pain and cooling down through impact on the center of thermostats in the hypothalamus, does not cause stomach irritation.

Paracetamol is usually a painkiller or antipyretic, especially in the elderly and in patients not prescribed use of salicylate or other nonsteroidal anti -inflammatory drugs.

These patients include people with asthma, people with a history of digestive ulcers and children.

pharmacokinetic

absorption

Paracetamol is absorbed quickly and almost entirely through the digestive tract. Foods can cause long -lasting release pellets to be slowly absorbed in paracetamol. Carbohydrate -rich foods reduce the absorption rate of paracetamol. The peak concentration of plasma is achieved within 30-60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is quickly and evenly distributed in most body tissues. About 25% paracetamol in the blood combined with plasma proteins.

Metabolism

paracetamol is n-hydroxylation by cytochrom paso to create N-acetyl-Benzoquinonimin (NAPO), a highly reactive intermediate.

This metabolite normally reacts with sulhydryl groups in the liver glutathione. In that situation, NAPQ is not connected to glutathione toxic to liver cells, leading to inflammation and can lead to liver necrosis.

Elimination

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage.

After the treatment dose, 90 - 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%). Also detected a small amount of hydroxyl metabolites - chemicals and reducing acetyl.

Children are less likely to glucoronic in accordance with the drug than adults.

Before taking Glotadol 650 Abbott medicine supports antipyretic and analgesic (200 tablets)

How to use

Glotadol 650 medicine is taken orally.

Dosage

Adults and children over 12 years: take 1 tablet/time, the distance between the medication from 4 - 6 hours, no more than 6 tablets/day.

Children from 6 to 12 years old: take 1 tablet/time, the distance between the medication from 4-6 hours, no more than 3 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Nausea, vomiting, abdominal pain and pale often appear in the first hour. Overdose of 10 g or more (150 mg/kg of children's weight) can cause liver cell destruction, leading to complete and non -recovery liver necrosis.

Metabolic acidosis and brain disease can lead to coma and death. In addition, the concentration of aminotransferase and bilirubin, ninotransferase and plasma bilirubin increases, prolongrombin time, can appear after 12 - 48 hours.

Handling

Gastrointestinal or drinking carbon to eliminate the medication immediately taken. Intravenous injection or n-acetylcysteine oral oral, distinctive antidote of paracetamol, most effectively is before the 10th hour after overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Glotadol 650, you may experience unwanted effects (ADR).

Side effects are usually mild and can recover after stopping the drug.

Uncommon, 1/1000

On the rash, rash or urticaria.

Stomach - intestines: Nausea, vomiting.

Hematology: neutropenia, leukopenia, hypocpturia, anemia.

Kidney: Kidney disease, kidney toxicity when abused for a long time.

Rare, ADR

Skin: Steven-Johnson syndrome (SJS), Poisoning skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

liver: liver dysfunction.

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Glotadol 650 drug contraindicated in the following cases:

hypersensitively to the ingredients of the drug.

Patients with glucose-6-phosphate dehydrogenase deficiency.

Hepatitis progressed, severe liver failure.

Be cautious when used

Not used with other drugs containing paracetamol.

Do not use paracetamol to treat pain relief for more than 10 days in adults or more than 5 days in children without a doctor's instructions.

Be cautious when used in patients with weakened liver or kidney function.

Be cautious for patients with a history of anemia.

Should avoid or limit alcohol when taking the drug as alcohol can increase the toxicity of paracetamol in the liver.

Doctors should warn the patient about signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

Cautious excipients: Propylene glycol can cause symptoms like drunkenness.

The ability to drive and operate machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may be available to the fetus. Therefore, this medication should only be used for pregnant women when necessary.

Breastfeeding period

There is no unwanted effect in breastfeeding when a mother uses paracetamol, and so the drug can be used during breastfeeding.

Drug interaction

long -term oral doses with high doses of paracetamol may increase the effect of anticoagulant drugs like COMAARIN or indandion derivatives.

Simultaneous use of paracetamol and phenothiazine can cause serious fever.

Out of alcohol too much and long may increase the risk of paracetamol toxicity in the liver.

The risk of toxicity of paracetamol toxicity on the liver increases when using high -dose paracetamol and prolonged while taking enzyme induction drugs in the liver microsom such as isoniazid or anti -convulsions (including phenytoin, barbiturate, carbamazepine). The excretion of paracetamol may be affected and the plasma paracetamol levels may change when used with probenecid.

Colestyramin reduces paracetamol absorption if used within 1 hour before or after taking paracetamol.

metoclopramid or domperidon may increase the speed of paracetamol absorption.

Storage

Leave in a dry place, avoid light, the temperature does not exceed 30 ° C.

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