Glotadol 650 Abbott supports antipyretic and analgesic (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen
Indication Sore throat, sinusitis, fever, dysmenorrhea, cold, headache, migraine, body aches
Contraindication Kidney failure, anemia

Ingredient

Composition information	Content
Acetaminophen	650mg

Uses

indications

Glotadol 650 pills are indicated in the following cases:

Reduce fever. The drug is not effective for treating inflammation. Paracetamol relieves pain by increasing pain and cooling down through impact on the center of the thermostat in the hypothalamus, without causing stomach irritation.

Paracetamol is usually a painkiller or antipyretics, especially in the elderly and in patients not prescribed Salicylate or other nonsteroidal anti -inflammatory drugs. These patients include people with asthma, people with a history of digestive ulcers, and children.

pharmacokinetic

absorption

Paracetamol is absorbed quickly and almost entirely through the gastrointestinal tract. Foods can cause long -lasting release pellets to be slowly absorbed in paracetamol. Carbohydrate -rich foods reduce the absorption rate of paracetamol. The peak concentration of plasma is achieved within 30 - 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is quickly and evenly distributed in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Elimination

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage. After the treatment dose, 90 - 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); Small amounts of hydroxylation and reduction of acetyl metabolites are detected. Young children are less likely to glucoro in line with drugs than adults. Paracetamol is n-hydroxylation by cytochrom P. to create N-acetyl-Benzoquinonimin (NAPQ), a highly reactive intermediate.

This metabolite normally reacts with sulhydryl groups in the liver glutathione; In that situation, NAPQ is not connected to glutathione toxic to liver cells, leading to inflammation and can lead to liver necrosis.

Before taking Glotadol 650 Abbott supports antipyretic and analgesic (10 blisters x 10 tablets)

How to use

oral medication.

Take the tablet with a glass of water.

Dosage

Adults and children over 12 years:

Take 1 tablet/time, the distance between the medication from 4 - 6 hours, no more than 6 tablets/day.

Children from 6 to 12 years old:

Take 1/2 tablets/time, the distance between the medication from 4 - 6 hours, no more than 3 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Nausea, vomiting, abdominal pain and pale often appear in the first hour. Overdose of 10g or more (150mg/kg of weight in children) can cause liver cell damage, leading to complete and non -recovery liver necrosis; Metabolic acidosis and brain disease can lead to coma and death. In addition, the concentration of aminotransferase and plasma bilirubin increases, the long prothrombin time can appear after 12 - 48 hours.

Handling

Gastrointestinal or drinking carbon to eliminate the medication immediately taken. Intravenous injection or n-acetylcysteine oral oral, distinctive antidote of paracetamol, most effectively is before the 10th hour after overdose.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Glotadol 650, you may experience unwanted effects (ADR).

Side effects are usually mild and can recover after stopping the drug.

Uncommon: 1/1000

On the skin: rash, erythema or urticaria.

Hypersensitivity reaction.

Instructions on how to handle ADR

Stop using and consulting your doctor if there is an abnormal new sign, symptoms do not improve after 7 days or with fever.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Glotadol 650 drug contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Precautions when using

Do not use with other drugs containing paracetamol.

Do not use paracetamol to treat pain relief for more than 10 days in adults or more than 5 days in children without a doctor's instructions.

Be cautious when used in patients with weakened liver or kidney function.

Precautions for patients with a history of anemia.

Should avoid or limit alcohol when taking the drug as alcohol can increase the toxicity of paracetamol in the liver.

Doctors need to warn the patient about signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug has almost no effect on driving and operating machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may be available to the fetus. Therefore, this medication should only be used for pregnant women when really necessary.

Breastfeeding period

There is no unwanted effect in breastfeeding when a mother uses paracetamol, and so the drug can be used during breastfeeding.

Drug interaction

long -term oral doses with high doses of paracetamol may increase the effect of anticoagulant drugs such as Coumarin or Indandion derivatives.

Simultaneous use of paracetamol and phenothiazine can cause serious fever.

Out of too much and long -term alcohol can increase the risk of paracetamol toxicity in the liver.

The risk of toxicity of paracetamol on the liver increases when using high -dose and prolonged paracetamol while taking enzyme induction drugs in the liver microsom such as isoniazid or anti -convulsions (including phenytoin, barbiturate, carbamazepine).

The excretion of paracetamol may be affected and the plasma paracetamol levels may change when used with probenecid.

Colestyramin reduces paracetamol absorption if used within 1 hour before or after taking paracetamol.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Other drugs

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