Glotadol Cold Glomed medicine supports pain relief and fever (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Acetaminophen, dextromethorphan, loratadine

Ingredient

Composition information	Content
Acetaminophen	500mg
Dextromethorphan	15mg
Loratadine	5mg

Uses

indications

Glotadol Cold Glomed drugs are indicated in the following cases:

Hydritesine treatment. The drug is not effective for treating inflammation. Paracetamol relieves pain by increasing pain and cooling down through impact on the center of the thermostat in the hypothalamus, without causing stomach irritation.

Paracetamol is usually a painkiller or antipyretics, especially in the elderly and in patients not prescribed Salicylate or other nonsteroidal anti -inflammatory drugs. These patients include people with asthma, people with a history of digestive ulcers, and children.

Dynamic pharmacokinetics

paracetamol is easily absorbed through the gastrointestinal tract.

Peak concentration in plasma occurs about 10 to 60 minutes after drinking. Paracetamol is distributed into most body tissues. It passes through the placenta and is in breast milk. Linking with plasma proteins is negligible at conventional treatment levels but increases as the concentration increases.

The drug is metabolized in the liver. A hydroxyl metabolic is usually produced in very small amounts by the oxidase of the mixed function in the liver, and is often detoxified by combining with glutathione in the liver, accumulating after overdose of paracetamol and tissue damage.

The drug is excreted in the urine, mainly in the form of glucuronid and sulfate. Selling waste time varies from 1 to 4 hours.

Before taking Glotadol Cold Glomed medicine supports pain relief and fever (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults and children over 12 years old

Take 1 tablet/time, the distance between the medication from 4 - 6 hours, no more than 6 tablets/day.

Children from 6 to 12 years old

Take 1/2 tablets/time, the distance between the medication from 4 - 6 hours, no more than 3 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Nausea, vomiting, abdominal pain and pale often appear in the first hour. Overdose of 10 g or more (150 mg/kg of weight in children) can cause liver cell destruction, leading to complete and non -recovery liver necrosis; Metabolic acidosis and brain disease can lead to coma and death. In addition, the concentration of aminotransferase and plasma bilirubin increases, the long prothrombin time can appear after 12 - 48 hours.

Handling

Gastrointestinal or drinking carbon to eliminate the medication immediately taken. Intravenous injection or n-acetylcysteine oral oral, distinctive antidote of paracetamol, most effectively is before the 10th hour after overdose.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Glotadol Cold Glomed 10x10, you may experience unwanted effects (ADR).

Uncommon, 1/1000

On the skin: rash, erythema or urticaria.

stomach - intestines: nausea, vomiting.

Hematology: neutropenia, leukopenia, all bloody hematoma, anemia. kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare, ADR

Immune: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Glotadol Cold Glomed 10x10 drug contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Patients with glucose-6-phosphate dehydrogenase deficiency.

Hepatitis progressed, severe liver failure.

Patients with many times anemia.

Be cautious when used

Not used with other drugs containing paracetamol. Paracetamol is relatively non -toxic at the dose of treatment. Sometimes skin reactions include rashes and urticaria; Other sensitive reactions include larynx edema, angioedema, and anaphylactic reactions that may rarely occur. Platelets, leukopenia, and all bloody hematuria have occurred with the use of p - aminophenol derivatives, especially when used for large doses.

Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Do not use paracetamol to treat pain relief for more than 10 days in adults or more than 5 days in children without a doctor's instructions.

Be cautious when used in patients with weakened liver or kidney function.

Precautions for patients with a history of anemia.

Should avoid or limit alcohol when taking the drug as alcohol can increase the toxicity of paracetamol in the liver.

Doctors need to warn patients on signs of serious skin reactions such as Steven-Jonhson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug does not cause adverse effects on the ability to drive and use machines.

Pregnancy

has not determined the safety of paracetamol used during pregnancy, when it comes to unwanted effects that may be available to the fetus. Therefore, this medication should only be used for pregnant women when really necessary.

The period of breastfeeding

does not see the unwanted effect in breastfed children when the mother uses paracetamol. Therefore, the drug can be used during breastfeeding.

Drug interaction

long -term oral doses with high doses of paracetamol can increase the effect of anticoagulant drugs such as COMARIN or indandion derivatives.

Simultaneous use of paracetamol and phenothiazine can cause serious fever.

Out of alcohol too much and long may increase the risk of paracetamol toxicity in the liver. The risk of toxicity of paracetamol in the liver increases when using high -dose paracetamol and prolonged while taking enzyme induction drugs in the liver microsom like isoniazid or anti -convulsions (including phenytoin, barbiturat, carbamazepine).

The excretion of paracetamol may be affected and the plasma paracetamol levels may change when used with probenecid.

Colestyramin reduces paracetamol absorption if used within 1 hour before or after taking paracetamol.

Storage

Leave in a dry place, avoid light, the temperature does not exceed 30 ° C.

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