Glubet Medisun treated the central diabetes, the first nightburn (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Desmopressin

Ingredient

Composition information	Content
Desmopressin	0.2mg

Uses

indications

Glubet drug indicated in the following cases:

central diabetes

ATC code: H01BA02.

Desmopressin - A similar substance of the structure of Arginin Vasopressin is natural hormone. The two chemical changes that have been made for this natural hormone are 1-cystein and 8-arginin replacement with 8-D-arginin. The variables of a compound structure with an anti -urinary resistance increase significantly, very little active on smooth muscles, so avoid unwanted side effects of hypertension. Used oral 0.1 - 0.2 mg Desmopressin for anti -urinary effects in most patients in 8 - 12 hours.

Dynamic pharmacokinetics

The bioavailability of desmopressin orally from 0.08% to 0.16%. The maximum concentration in plasma is achieved within 2 hours. The distribution volume is 0.2 - 0.37 l/kg. Desmopressin does not pass the brain barrier. Selling time of excretion 2.0 - 3.21 hours. About 65% of the absorption desmopressin after drinking can be regained in the water within 24 hours.

Before taking Glubet Medisun treated the central diabetes, the first nightburn (3 blisters x 10 tablets)

How to use

Glubet drugs for oral, can be taken at full or hungry.

Note when using Desmopressin with food because of food collection reduces absorption and therefore can also affect the effect of desmopressin.

Dosage

The dose of the tablet is controlled by individuals depending on the achievement of efficiency and the ability to tolerate

Central diabetes:

Adults and children (from 6 years old):

The starting dose is suitable for children and adults is 0.1 mg, 3 times/day. Then the dose is done according to the patient's response.

According to the current clinical experience, daily dose changes between 0.2 mg and 1.2 mg. For most patients, the optimal dose is 0.1 - 0.2 mg, 3 times/day. When signs of water stasis/sodium hypoglycoc must be stopped and do the dose.

Evil Night First Infinity:

Adults and children (from 6 years old):

The appropriate starting dose is 0.2 mg at bedtime. This dose increases to 0.4 mg if the lower dose is not effective enough. Must be limited to epidemics. In the case of signs or symptoms of water stasis and/or hyponatremia (headache, nausea/vomiting, weight gain and in cases of severe seizures) must stop treatment until the patient recovers completely. As the treatment continues to return, strict fluid restriction is necessary. Evaluation of the continued treatment needs should be done after 3 months at least 1 week of non -treatment.

Night:

Only used for adults:

The recommended starting dose is 0.1 mg at bedtime. If this dose is not effective enough after 1 week, it may increase to 0.2 mg, then 0.4 mg by increasing weekly. Must be limited to epidemics.

In night urine patients, the chart of the number of times/volume should be used for a diagnosis of at least 2 days and nights before starting treatment. The production of urine throughout the night exceeds the function of the bladder or exceeds the 1/3 of the urine production in 24 hours is considered a multi -night diuretic.

The beginning of treatment in the elderly (65 years and older) is not recommended. If it is necessary to consider the treatment of these patients, sodium serum must be quantified before starting treatment and 3 days after the beginning of treatment or increasing the dose in other times during the treatment period when the treatment is necessary.

If there are signs or symptoms of water stasis and/or hyponatremia (headache, nausea, vomiting, weight gain and convulsions in severe cases), it is necessary to stop treating until the patient recovers completely. As the treatment continues to return, strict solution restriction is necessary.

If there is no complete clinical effect within 4 weeks after adjusting the appropriate dose should stop taking the drug.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Treatment: Although the treatment of blood hyponemia must be followed by each patient, the following general recommendation: Desmopressin treatment stops, restricting fluid and symptomatic treatment if necessary.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Classification by frequency ADR: Very common> 1/10; Common 1/100; less common 1/1000; rarely 1/10 000; Very rare

Unknown frequency (frequency cannot be estimated from available data).

The treatment is not accompanied by a decrease in fluid receiving can lead to sodium stasis/sodium retenty or without warning signs and symptoms (headache, nausea/vomiting, weight gain and seizures in severe cases).

Essay at night and diabetes:

Neurological disorders Common: headache Experiment after marketing on the market

is very rare: emotional disorders in children.

Unknown frequency: Allergic skin reactions and more serious allergic reactions.

In clinical trials, about 35% of patients experience side effects of the drug while adjusting the dose. In long -term treatment, about 24% of patients appear side effects. Most cases of sodium lowering (sodium Drought treatment: Long -term treatment:

Neurological disorders Nursing Common: Lower blood sodium Common: peripheral edema Through

and other disorders

Instructions on how to handle ADR:

Unwanted effects when using desmopressin are often lost when reducing the dose or reducing the number of treatments but rarely need to stop the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

anti -contraindications in the following cases:

Patients who are sensitive to desmopressin or any excipients of the drug

thirst for the habit or mental illness

have known or suspected heart failure. The anti -hormone secretion syndrome is inappropriate (SIADH).

Be cautious when using

Patients who cannot control the urination, the physical causes for increasing the number of urination and night urination (for example, benign prostate hyperplasia (BPH), infections of cotton sugar, bladder stones), poor thirst and poor adjustable diabetes, need specific treatment.

In the treatment of first night bedwetting or night urine, the reception of epidemics is limited to the lowest possible level for 1 hour before taking the drug and 8 hours after taking the drug.

The non -combination treatment of fluid collection can lead to water stasis and/or hyponatremia, with or without signs and symptoms of leopard (headache, nausea, vomiting, weight gain and seizures in severe cases).

In clinical trials, hypoglycry hypoglycemia has occurred more in patients over 65 years old. Therefore, it is not recommended to start treatment in the elderly, especially not recommended for patients with other conditions that may increase the possibility of imbalance of epidemic or electrolytes.

Elderly patients, patients with low serum sodium levels and patients with urine volume in 24 hours (over 2.8 - 3 liters) are at high risk of hypoglyc sodium.

Be careful to avoid hyponatremia, including careful attention to fluid restrictions and must monitor serum sodium more often in the following cases:

Simultaneous treatment with known drugs causes an inappropriate anti -hormone secretion syndrome (SIADH), for example 3 -round antidepressants, selective re -acquisition inhibitors, chlorpromazine and carbamazepin.

Mimeting treatment with nonsteroidal anti -inflammatory drugs (NSAID).

Should stop treating desmopressin in acute generators are characterized by an imbalance of fluid and/or electrolyte such as systemic infections, fever, gastritis.

Lactose -containing tablets. Ancient patients with rare genetic problems in tolerance of galactose, lactase deficiency or malposive glucose-galactose should not be taken.

The effect of the drug on the ability to drive and operate machinery

can cause drowsiness and face resistance and can affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

pregnancy:

Data on a limited amount (n = 53) Ancient women with diabetes with diabetes show no side effects of desmopressin on pregnancy or on the health of the fetus/infant. Animal studies do not show directly or indirectly harmful effects on pregnancy, embryo/fetal development, childbirth or development after birth.

Be careful when prescribing pregnant women

breastfeeding period:

The results of nursing mothers' milk analysis for high doses of Desmopressin (300 mcg used in the nose) show that the amount of desmopressin can be transferred to the child is significantly less than the amount that needs to affect the card.

Drug interaction

The substances are known to disrupt anti -urinary hormones (ADH), for example 3 -round antidepressants, selective reconciliation inhibitors, chlorpromazine and carbamazepin can cause anti -an anti -diuretic effect with the risk of increased fluid.

Steroid anti -inflammatory preparations (NSAID) can cause water stasis/hyponatremia.

Simultaneous treatment with necklemia lopteramid leads to tripled plasma desmopressin concentrations, which can lead to an increase in the risk of water stasis/hypoglyc sodium.

Although not studied, other drugs slow the intestinal transport may have the same effect.

Not sure that the desmopressin interacts with drugs that affect the metabolism in the liver, because the desmopressin has not been recorded through any significant passing of the liver in in vitro studies with human mites. However, no official studies have been conducted in Vivo. A standardized meal with 27% fat has reduced absorption (level and absorption rate) Desmopressin orally. No significant effects on pharmacological effects (urine production or osmotic).

Use food that reduces the intensity and time of the anti -urinary effect of the drug when using the oral low -dose desmopressin.

Storage

Store in sealed bags, avoid moisture, avoid light, at a temperature not exceeding 30 ° C.

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