Glucobay 50 Treatment combines diet for patients with diabetes (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Acarboose

Ingredient

Composition information	Content
Acarboose	50mg

Uses

indications

Glucobay 50 drugs are indicated in the following case:

Treatment combines diets for diabetic patients. Prevention of type 2 diabetes onset in people with sugar tolerance disorders, combining diet and exercise.

Pharmacological

Acarbose is a tetrasacharid, the activity of acarboose manifests itself in the digestive tract. Effects based on α-glucosidase inhibiting mechanism, this is an intestinal enzyme, catalyst for the decalence of disaccharid, oligosaccharid and polysaccharid.

This leads to slow digestion and carbohydrate absorption. By this mechanism, Acarbose will slow down and reduce hyperglycemia after eating. As a result, glucobay works to balance the absorption of glucose through the intestine, the oscillation of blood glucose during the day will decrease and reduce the average value of blood glucose.

Dynamic pharmacokinetics

absorption and bioavailability: Poor absorption drugs in the gastrointestinal tract, bioavailability

DISTRIBUTION: The relative distribution volume is 0.32L/kg of body weight calculated on healthy people from the concentration of drug in blood (venous doses of 0.4mg/kg of body weight).

Metabolism and excretion: A acarbose plasma waste time is 3.7 ± 2.7 hours for the distribution phase and 9.6 ± 4.4 hours for the elimination phase. The ratio of Acarbose is discharged in urine is 1.7% of the dose, 51% of activity is discharged within 96 hours by feces.

Before taking Glucobay 50 Treatment combines diet for patients with diabetes (10 blisters x 10 tablets)

How to use

Glucobay is only valid when swallowing pills with some water right before meals or chewing with a little food right in the first pieces of food.

Dosage

unless prescribed in another way, the dose is as follows:

Start: 50mg (1 Glucobay 50mg or 1/2 Glucobay 100mg) x 3 times/day.

Next: 100mg (2 Glucobay tablets 50mg or 1 Glucobay 100mg) x 3 times/day.

Sometimes it is also necessary to increase the dose, up to 200mg of glucobay/time, 3 times a day.

If the patient has not had appropriate clinical response in the previous treatment process, it may increase the dose after 4 to 8 weeks. If you encounter exhaustion, although you have strictly follow the diet, you should not increase the dose even more, but may need to reduce the dose. The average dose is 300mg of glucobay/day (corresponding to 2 Glucobay tablets 50mg/time or 1 Glucobay tablet 100mg/time, 3 times a day).

Dosage and use in the treatment of type 2 diabetes in patients with sugar tolerance disorders:

Recommended dose: 100mg x 3 times/day.

Should start treatment at a dose of 50mg x 1 time/day and increase to 100mg x 3 times/day for 3 months.

Special subjects

Children and teenagers: See the "Warning and Caution" section

The elderly (over 65 years old): No need for dosage or time to use drugs according to the patient's age.

Patients with liver failure: No need to adjust the dose in patients who have liver function before.

Renal failure: please read the contraindications.

There is no comment on limiting the use of acarbose tablets.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Handling: In case of overdose, patients should not use food and drinks containing carbohydrates for the next 4-6 hours.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects are digesting such as: bloating, stool, diarrhea, abdominal distention and pain.

Less: nausea, abnormal liver function test, increased liver enzyme.

Rare: jaundice; Phu.

Unknown frequency: platelet reduction; Allergic reactions (rash, erythema, foreign rash, urticaria); Inflammation/ intestinal obstruction, bowel follicle; Hepatitis.

If the diet is not monitored, the prescribed diet for diabetes patients, adverse effects in the intestine may increase. If there are severe disorders, although it has comply with the prescribed diet, must go to the doctor immediately and have to reduce the dose of temporary or long -term drugs.

In patients with daily doses of 150mg to 300mg of glucobay/day, rare rare for clinical liver function tests (i.e. the test value is 3 times the maximum boundary permitted). These are fleeting effects when using Glucobay treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Glucobay 50mg drug is indicated in the following case:

Hypersensitivity to acarbose or any ingredient of the drug. heavy (clearance

Caution when using

need to monitor liver transaminase (6-12 weeks of medication) during acarboose treatment because there are cases of liver enzyme increased.

Safety and effectiveness of glucobay for patients under 18 have not been proven.

may occur hypoglycemia when taking acarboose simultaneously with a anti -diabetic drug Sulfonylure and/or insulin.

Need special care in patients with diabetes in ketone acidosis. The drug has no effect when used alone in people with diabetes with complications of acidosis, increased keratoma or coma - in these cases, insulin must be used.

The ability to drive and operate machinery

There is no data showing that Acarbose affects the ability to drive and operate machinery.

Pregnancy

No glucobay is not indicated during pregnancy. Because there is no information about the use of drugs for pregnant women.

The period of breastfeeding

has not excluded the effects of acarbose caused on young children; In general, Glucobay should not be indicated during breastfeeding.

Interactive drug

During acarbose treatment, sucrose (white sugar) and foods containing sucrose often cause abdominal discomfort, can cause diarrhea due to increased carbohydrate fermentation in the colon.

Acarbo

Patients who use sulfonylure, insulin or metformin: Sulfonylure, insulin or metformin drugs may cause hypoglycemia. Acarbose is used in combination with a sulfonylurea, insulin or metformin drug that can reduce blood sugar and can increase the ability to hypoglysia. If hypoglycemia occurs, adjust the dose appropriately for these drugs. There are rare cases of single cases of hypoglycemia reported in patients treated with acarbose in combination with sulfonylure, insulin and/or metformin.

Acarbose has been found to change the bioavailability of digoxin when used simultaneously, so it may be necessary to adjust the dose of digoxin.

It is necessary to avoid simultaneous use with anti -acid, cholestyramine drugs, adsorbent in the intestine and digestive enzymes because it can reduce the effect of acarboose.

There is no interaction between acarboose and dimeticon/simeticon.

Simultaneous use of glucobay with oral neomycin can lead to an increase in post -eating blood sugar and increasing the frequency and the seriousness of the adverse effects on the digestive tract. If serious symptoms should consider temporarily reducing the dose of glucobay.

Some drugs that increase blood sugar and can lead to loss of blood sugar control. These drugs include thiazids and other diuretics, corticosteroids, phenothiazine, thyroid drugs, estrogen, oral contraceptives, phenytoin, nicotinic acid, sympathetic medications, calcium channel blockers and isoniazid. When these drugs are used in patients using Glucobay, patients must be closely monitored by blood sugar loss.

Storage

Leave a cool dry place, avoid light, avoid moisture, temperature below 30⁰C.

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