GOFEN 400 mega We Care medicine for antipyretic, analgesic (5 blisters x 10 tablets)

Dosage form Soft capsules
Specifications Box of 5 blisters x 10 tablets
Ingredient Ibuprofen
Indication Headache, dysmenorrhea, back pain, arthritis, body aches, lower body heat
Contraindication Hepatic failure, kidney failure, drug allergy, bronchial asthma, heart failure

Ingredient

Composition information	Content
Ibuprofen	400mg

Uses

indications

GOFEN 400 drugs are indicated in the following cases:

Analysis of the flu, headache, toothache, muscle aches, back pain, mild pain due to arthritis, sprain pain, dysmenorrhea. Like other nonsteroidal anti -inflammatory drugs, ibuprofen has an analgesic, antipyretic and anti -inflammatory effect. The mechanism of action of the drug is inhibiting the prostaglandin synthetase and thus prevents producing prostaglandin, thromboxan and other products of cyclooxygenase.

ibuprofen also inhibits prostacyclin synthesis in the kidneys and may cause water stasis due to reducing blood flow to the kidneys. It is necessary to pay attention to this for patients with kidney failure, heart failure, liver failure and disorders with plasma volume disorders.

Ibuprofen's anti -inflammatory effects appear after two days of treatment. Ibuprofen has an antipyretic effect faster than aspirin, but less indomethacin. The drug has good anti -inflammatory effects and has good analgesic effect in the treatment of teenagers.

ibuprofen is the safest drug in nonsteroidal anti -inflammatory drugs.

pharmacokinetic

absorption

ibuprofen quickly absorbed from the digestive tract and the peak concentration in plasma reached 1 to 2 hours after drinking.

Distribution

ibuprofen is strongly attached (99%) to plasma proteins, but the drug only accounts for a small part of the total points attached to the drug at conventional concentrations. Ibuprofen penetrates slowly into the epidemic and concentration in the epidemic may be higher in plasma. In experimental animals, ibuprofen and its metabolites are easily absorbed through the placenta.

Metabolism

ibuprofen is metabolized in the liver to form two inactive metabolites, these substances are eliminated through the kidney with ibuprofen in constant form or in their combined form. The renal excretion is fast and completely.

Elimination

ibuprofen excreted quickly and completely. Over 90% of oral doses except for urine in the form of metabolites or conjugate and ibuprofen form has not metabolized in urine. Most metabolites in the form of hydroxylate and carboxylate. Selling time for plasma is about 2 hours.

Before taking GOFEN 400 mega We Care medicine for antipyretic, analgesic (5 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults and children over 12 years: 1 tablet every 4 - 6 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Symptoms of overdose are nausea, vomiting, dizziness, convulsions, loss of consciousness and depression. Usually large dose is well absorbed when not in combination with other drugs.

Overdose

If you have overdose, you need to apply the following measures to increase the elimination and inactivity: gastric lavage, vomiting and diuretic, drinking activated carbon or salt medicine. Because the drug causes acidosis and eliminating urine, the drug will be beneficial when transmitting alkaline and diuretic. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using GOFEN, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic: Fever, fatigue.

digestion: bloating, nausea, vomiting.

Neurology: headache, dizziness, dizziness, restlessness.

Skin: Rashes, urticaria.

Uncommon, 1/1000

Immune: allergic reactions (especially bronchospasm in people with asthma), rhinitis, urticaria.

Digestive: Abdominal pain, stomach bleeding, progressive stomach ulcer.

Neurological: Drinking, insomnia.

Other disorders: tinnitus, visual disorders, decreased hearing, prolonged bleeding.

Rare, ADR

Body: edema, rash, Steven - Johnson syndrome, hair loss.

Mental: depression. Neurology: Aseptic meningitis, blurred vision, color disorders. Hematology: leukopenia, anemia. Other disorders: liver poisoning, gallbladder contraction disorders, cystitis, hematuria, acute kidney failure, interstitial nephritis, nephrotic syndrome, cardiovascular thrombosis, vision loss due to drug poisoning.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

GOFEN 400 Pills contraindicated in the following cases:

Hypersensitivity to ibuprofen and other ingredients of the drug.

Patients with progressive peptic ulcer.

Patients with a history of asthma, urticaria or sensitivity to aspirin and other nonsteroidal anti -inflammatory drugs.

Patients with a history of bleeding or gastrointestinal perforation are associated with the use of other nonsteroidal anti -inflammatory drugs.

Patients with asthma or bronchospasm, bleeding disorders, cardiovascular disease.

Patients are being treated with anticoagulants.

Patients with congestive heart failure, reduced circulatory mass due to diuretic or kidney failure (increased risk of kidney dysfunction).

People with glue (at risk of aseptic meningitis, it should be noted that all patients with aseptic meningitis have a history of an autoimmune disease).

Severe liver and kidney function.

The last 3 months of pregnancy.

Be cautious when using

Do not coordinate ibuprofen with aspirin and other nonsteroidal anti -inflammatory drugs because of the risk of gastrointestinal irritation.

Do not take medicine with alcoholic drinks.

Caution for patients with peptic ulcer.

Stop using ibuprofen and consult your doctor if there is still a fever after 3 days or pain after 10 days of medication.

Heart thrombosis

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms.

Patients need to be warned about the symptoms of serious cardiovascular events and need to see a doctor as soon as these symptoms appear. To minimize the risk of adverse incidents, Gofen 400 is needed at the lowest daily dose in the shortest possible time.

The ability to drive and operate machinery

Do not drive or operate machinery if you feel dizzy, dizziness, drowsiness or vision disorders after taking the drug.

Pregnancy

should not be used for pregnant women (especially in the first 3 months and the last 3 months of pregnancy), labor or lactating women. Non -steroid anti -inflammatory drugs can also cause severe lung pressure and severe infant respiratory failure due to early closing of the ductus arteriosus in the uterus. Anti -inflammatory drugs can inhibit uterine contractions and slow down. Anti -inflammatory drugs can also inhibit platelet function, increasing the risk of bleeding.

Breastfeeding period

ibuprofen into breast milk is very small, negligible. Less likely to occur risks for children at normal doses with mothers.

Drug interaction

Not coordinated with:

Other nonsteroidal anti -inflammatory drugs, including high -dose salicylats: There is a risk of ulcer and gastrointestinal bleeding due to the co -effect. ulcerative. 15mg/week.

Precautions when coordinating with:

Diuretics: The risk of acute renal failure in patients with dehydration due to reduced platelet filtration.

Storage

Store in cool dry places, below 30 ° C. Avoid direct light.

Other drugs

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