Golistin Enema rectal solution for constipation and intestinal cleansing before surgery (133ml)

Dosage form 1 bottle box
Specifications Sodium phosphate, sodium phosphate dibasic

Ingredient

Thành phần cho 1 chai

Composition information	Content
Monobasic sodium phosphate	21.41g
Dibasic sodium phosphate	7.89g

Uses

indicated

golistin enema indicated treatment in the following cases:

Treatment of constipation irregularly. The drug has a laxative effect due to the impact on the osmotic pressure in the intestine. When using the sodium salts of phosphate along the rectum, these salts will pull the water into the intestine, soften the stool, enhance the contraction of the intestinal motility that promotes the elimination of fecal so it has the effect of indentation.

Dynamic pharmacokinetics

The drug is used in the rectum.

The absorption of the drug through the rectum is very low. There is no phenomenon of increased blood phosphorus to 2-3 times compared to normal levels at about 25% of individuals with normal kidney function after taking laxatives containing sodium phosphate salt 3.92 g.

Research data on a small group of volunteers after using a laxative solution through the rectum with a large vol Under normal conditions, phosphate absorption occurs mainly in the small intestine, it is impossible to occur this case when used through the rectum.

Before taking Golistin Enema rectal solution for constipation and intestinal cleansing before surgery (133ml)

How to use

Rectal indentation

How to use with the left side position: let the person lying on the left, kneeling kneeling and hands to comfortably.

How to use with the position of the knee - chest:

kneeling, lowering his head and pulling his butt up, his face tilted to the right, his left hand rolled comfortably under the abdomen.

remove the lid before use.

Use the force to gently put the tip of the tube to the anus and push slowly, the tip of the tube facing the middle of the rectum. Absolutely do not push the tip of the tube into the rectum due to the damage to the rectum. Putting the pipe into the rectum will be easier if the drug is put in a downward position due to the movement of the intestine. This helps relax the muscles around the anus.

Squeeze the vial until almost all the liquid in the jar is out. It is not necessary to completely push the amount of liquid in the vial because the vial always contains more drugs than the requirements.

withdraw the tip of the drug tube from the rectum and keep the posture until there is a sorrow of defecation (usually about 2-5 minutes).

Use once a day.

Adults and children aged 12 and older: 1 bottle of golistin enema.

Children 2 to 12 years old: Use bottles for children Golistin Enema for Children.

Clean the intestine before surgery, X-ray or laparoscopy: Use 1 vial before surgery or test for 3 to 5 hours, or as directed by the doctor. Do not use more unless the doctor's instructions.

Adjusting the dose in patients with renal impairment and patients with hepatic impairment:

Patients with renal impairment: Do not use for patients with renal impairment with clear clinical manifestations. Be careful when used in patients with renal failure, considering the benefits greater than the risk of alkaline phosphate.

Patients with liver failure: No dose adjustment in patients with liver failure.

Elderly: Do not use golistin enema in people from 70 years of age and older. People aged 55 and older need to consult a doctor before using the drug.

Combined with an oral solution proposed in cases where intestinal cleansing.

Do not use repeated and prolonged golistin enema can cause drugs. Using more than 1 bottle of indented solution for 24 hours can be harmful. Do not use for more than 1 week unless the doctor's instructions.

Do not use more unless the doctor is indicated.

What do

do when overdose?

Overdose of drugs (using more than 1 bottle of indented solution within 24 hours) or no lottery effect (without the movement of stools after using the drug) can lead to serious electrolyte disorders, including hyperconemia, blood phosphate, blood calcium reducing and reducing blood potassium as well as dehydration and reducing blood volume accompanied by signs and symptoms of these disorders (such as metabolic acid contamination). Extend the time of QT and/ or more severe cases, multi -organized failure, arrhythmia/ cardiac arrhythmia and death. Patients with overdose should be carefully monitored. Treatment of electrolyte imbalance should be applied immediately with water and electric compensation therapy.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Goolistin Enema tolerates well when used as directed.

However, some unwanted effects due to the reported Golistin Enema have been reported. In some cases, unwanted effects may appear when abuse.

Unwanted effects that can be encountered are:

Very rare (frequency

Immune system disorders: Hypersensitivity reaction for example.

Skin and subcutaneous tissue disorders: blistering, itching, aches and pains.

Disorders of metabolism and nutrition: dehydration, alkaline phosphorus, blood calcium, hypokalemia, hyperkemia, metabolic acidosis.

Gastrointestinal disorders: Nausea, vomiting, abdominal pain, abdominal pain, diarrhea, stomach pain, anal discomfort and anal pain.

Other disorders and disorders related to the use: Rectal irritation, pain, aches, chills. Pressing the tip of the vial is too strong can cause perforation and/ or rectal damage.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Golistin Enema Contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Children under 2 years old; Older people aged 70 years and older.

Be cautious when using

only use rectal, no orally (or other lines).

If you swallow this medication, you need medical assistance or contact the Poison Control Center.

consult your doctor before using any enema if the patient:

There is kidney disease.

is in a strict salt diet.

nausea, vomiting or abdominal pain.

Change abnormal defecation habits for more than 2 weeks.

has used an enema that lasts more than 1 week.

Thận trọng khi sử dụng thuốc ở bệnh nhân đang hoặc có nguy cơ gặp phải tình trạng mất dịch, bệnh nhân bị tổn thương cầu thận hoặc đang sử dụng các thuốc làm giảm tốc độ lọc cầu thận như thuốc lợi tiểu, thuốc ức chế men chuyển (enalapril, ramipril, lisinopril), thuốc chẹn thụ thể angiotensin (losartan, candesartan, eprosartan, irbesartan, olmesartan, Telmisartan, Valsartan) or nonsteroidal anti -inflammatory drugs (NSAIDs).

Need to supplement oral fluid with intestinal cleansing doses to prevent dehydration.

Be cautious when using Golistin - Enema in elderly patients, renal failure, patients with hypotension, patients with uncontrolled arterial hypertension, ascites, heart disease, rectal mucosa (ulcerative ulcer, mucosal crack), patients with intestinal surgery being treated with diuretics or other drugs that may affect electricity, people who are taking medicine for qt (amiodararon, arsenic, arsenic Astemizol, azithromycin, erythromycin, clarithromycin, clepopromazin, cisaprid, citalopram, domperidon, terfenadin, process) or have the risk of electrolyte imbalance such as blood calcium lowering blood calcium, hypotension, phosphorus and hyperlemenemia.

Be cautious when using drugs in patients with reduced intestinal peristalsis such as colon aneurysm, or other conditions that can save fluid in the intestine.

Sadness appears after about 5 minutes from the use of Golistin - Enema. Therefore, the time to store drugs in the gastrointestinal tract for over 5 minutes is not recommended.

If the bowel movement does not appear after taking the drug or the time to store fluid in the digestive tract lasts for 10 minutes or more, the unwanted effect may occur. Stop using drugs and consult a doctor immediately to check and explore electrolyte disorders, and reduce the risk of serious blood phosphorus.

Be cautious when taking the drug because the drug can cause electrolyte disorders due to sodium and phosphate increased. Golistin - Eenema contains sodium and phosphate, therefore, there is a risk of increasing sodium and phosphorus concentration in serum and reducing calcium and potassium levels. Increased concentration of sodium and phosphate, reducing calcium and potassium levels in serum can appear with manifestations such as tetany and renal failure.

Need to monitor electrolyte carefully in suspected patients and have had blood phosphorus.

This drug contains benzalkonium chlorid, which is an irritant and causes skin reaction.

Stop medication and consult a doctor if the patient:

Rectal bleeding.

There is no mass movement after using Golistin Enema.

These symptoms may indicate a serious condition. Stop using the drug and see the doctor immediately.

The ability to drive and operate machinery

There is currently no effect of the drug's effect on driving and operating machinery.

Pregnancy

There is no data related to the ability to cause deformities and other toxicity on the fetus when the mother uses Golistin - Enema. Therefore, Golistin - Enema should only be used according to the doctor's instructions at the time of childbirth and after birth.

The period of breastfeeding

Sodium phosphate can pass through breast milk, it is excreted from breast milk for at least 24 hours after using Golistin - Enema. Caution should be used when using golistin - enema for nursing mothers.

Drug interaction

should not be used simultaneously with other drugs with other drugs containing sodium phosphate include the form of oral solution or tablet form. Electrolyte disorders and hypoglycemia due to enema may be more serious due to insufficient drinking, vomiting, anorexia or using diuretics, angiotensin transferring enzymes, angiotensin receptor blockers, nonsteroidal anti -inflammatory drugs, and lithium drugs or drugs that affect electrolytes, and can cause metabolic acid, periodic, long -term acid, periodic, long -term acidity Multi -organized impairment, arrhythmia/cardiac arrhythmia and death.

Due to hyperemia associated with low lithium concentrations, simultaneous use of golistin - enema and lithium can lead to lithium concentration and reduce the effects of the drug.

Storage

Put in a cool, dry place, avoid light, temperatures below 30 ° C.

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