Gourcuff-5mg medicine is achieved to treat benign prostatic hypertrophy (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Alfuzosin

Ingredient

Composition information	Content
Alfuzosin	5mg

Uses

Indications

gourcuff 5 is used to treat functional symptoms due to benign prostatic hypertrophy.

Pharmacokology

ATC code: G04CA01.

Pharmacological group: Alpha-adrenergic antagonists, used in benign prostatic hypertrophy, alpha antagonists.

alfuzosin is a derivative of quinazolin oral, has the effect of selecting antagonistic alphat-adrenergic receptors.

Alfuzosin has structure and pharmacy related to prazosin, doxazosin and terazosin and pharmacology related to tamsulosin. Alfuzosin has a selective effect with alphal-adrenergic receptors in the lower urinary tract, prostate, prostate shell, bottom, bladder neck and urethra.

Medicines directly acting on prostate smooth muscles; Reduces obstruction in the neck of the bladder and reduces urethral pressure, so the drug reduces the urine flow. In vivo research shows that alfuzosin has a more selective effect than prazosin or terazosin for alpha receptors, in the lower urinary tract compared to the circuit system.

Unlike prazosin or terazosin, alfuzosin can reduce the effectiveness of the urethra with a dose that does not affect blood pressure. On the isolated human tissue, alfuzosin compared to Tamsulosin, Doxazosin and Terazosin have the highest selective rate for prostate tissue on vascular tissue. In clinical, selective properties for the lower urinary tract of alfuzosin are not affected by the age of the patient.

The effect of reducing the urethra pressure of the drug is much larger than lowering blood pressure.

In benign prostatic hypertrophic patients with urine flow below 15 ml/ sec, alfuzosin increases the flow of about 30%. This effect appears right after the first dose; Significant reducing the pressure of the bladder muscle contraction and increasing the volume of urine causing urination, as well as reducing the volume of urine out of the bladder after urinating.

These effects reduce the symptoms of irritation and obstruction.

For cardiovascular, drugs that lower blood pressure, but the manufacturer thinks that alfuzosin should not be used to treat hypertension. Alfuzosin works to lower blood pressure compared to doxazosin, terazosin and tamsulosin.

Alfuzosin has also been used as a clogged ureteral stones when taking 10 mg/time/day (stopping the drug after clearing), used for about 1-2 weeks (patients with stones> 10 mm removed from the study). However, this indication is still researched, not licensed to use.

pharmacokinetics

The pharmacokinetics characteristics of alfuzosin vary for users.

absorption

The drug is well absorbed after oral, the blood concentration in the blood is reached after about 1.5 hours (0.5 - 3 hours). The bioavailability of the drug is about 64%. The sale time of alfuzosin is about 3 - 5 hours.

distribution

Alfuzosin binds about 90% to plasma proteins.

metabolism and elimination

A large metabolic drug by liver by cytochrom paso isoenzym CYP3A4 into non -activity metabolites, excreted mainly through feces (75 - 90%) due to secretion through bile. About 11% of the dose is eliminated in urine in the form of constant.

Special subjects

Elderly

Although there is no difference in efficiency and safety between the elderly and young people and there is no evidence of the difference related to age, not excluded may have some elderly people may be more sensitive to the drug.

Patients with liver failure

In people with severe liver failure, the sale time lasts longer, the bioavailability of the drug also increases compared to in a healthy volunteer.

Patients with renal failure

In people with renal failure, it is necessary to make fertilizer or not, the distribution integral and the clearance of taxes increase due to the increase in the freelance form. Do not make chronic kidney failure.

Patients with heart failure

In patients with chronic heart failure, the pharmacokinetic properties of the drug have not changed.

Before taking Gourcuff-5mg medicine is achieved to treat benign prostatic hypertrophy (10 blisters x 10 tablets)

How to use

Used by oral.

The dosage is calculated in the form of Alfuzosin HCl. The first dose must be taken in the evening before going to bed.

Dosage

The usual dose is 2.5 mg, 3 times a day, can increase to 10 mg daily if needed.

Elderly patients or taking anti -hypertension drugs, the starting dose is 2.5 mg, twice a day, increasing the dose depending on the response of the patient.

For patients with mild and medium liver failure, the starting dose is 2.5 mg, once a day, the dose can be increased depending on the response of the patient but not exceeding 2.5 mg, 2 times a day.

For patients with renal insufficiency, the starting dose is 2.5 mg, twice a day, increasing the dose depending on the response of the patient.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

In case of overdose, the patient has severe hypotension.

Management:

Can give patients activated charcoal if they first drink alfuzosin within 1 hour. Applying treatment for hypotension such as low head lying, transmission additional volume of circulation.

If necessary, intravenously venous medications can be careful.

Alfuzosin is highly linked to protein, so it cannot be removed by hemolysis.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects are separated by frequency and organ system.

Common, 1/100

Gastrointestinal disorders: Nausea, abdominal pain, diarrhea 1/100

Neurological: dry mouth, weakness, drowsiness.

Hypotension stands, fainting, hitting chest drum, edema, itching, usually only occurs in hypertension people.

The drug can cause other unwanted effects, advising patients to notify unwanted effects when taking the drug.

Instructions on how to handle ADR

ADR of the drug such as dizziness, dizziness, headache, weakness, nausea, and chest drums may end when continuing to treat or reduce the dose.

To reduce the risk of fainting, fainting after the first dose, should take the drug in the evening before going to bed. Elderly should reduce the first dose.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Gourcuff drugs contraindicated in the following cases:

Hypersensitivity to alfuzosin or any ingredients of the drug.

Be cautious when using

just like other alpha antagonists, alfuzosin can cause vertical or no symptoms (such as dizziness).

Use medication to be cautious for people with symptoms of hypotension or have hypotension when taking other drugs, which should be wary of falling. In particular, after the starting dose, the patient may have severe hypotension leading to fainting, notice by tachycardia.

If fainting, the patient must be low and support for support if needed. The hypotension effect of the drug increases when the patient is physical activity, drinking alcohol or hot. However, these blood pressure symptoms are often passed quickly, not necessarily stop treatment.

Because the symptoms of cancer and benign prostatic hypertrophy are the same, it is necessary to eliminate cancer before starting treatment.

Soft pupil syndrome during surgery (iFis: intraoperative floppy iris syndrome) has been encountered during cataract surgery with lakoemulsification in some patients currently taking or previously taking alpha antagonistic drugs. Men before cataract surgery should notify the current eye doctor or previously treated alpha antagonistic drugs, including alfuzosin. If the patient has taken this medicine, the doctor should replace other techniques.

When using alfuzosin is higher than the recommended dose, the QT range may last. However, up to now, there has not been a twisted appearance in the person using alfuzosin. The manufacturer believes that the extended QT interval in users the alfuzosin dose is higher than the recommended dose, which should be considered when using alfuzosin for people who know that there is a long -lasting QT or the person who is using the drug has known for a long time.

Be cautious and should reduce the dose in people with mild and medium liver disease, kidney disease and the elderly. Alfuzosin should not be used alone in people with coronary artery disease. Need to continue treating coronary coronary insufficient disease for patients. If angina occurs or worse, alfuzosin should be stopped.

The drug contains lactose, patients with rare genetic diseases galactose, Lapp Lactase deficiency or glucose - galactose absorption disorders should not use this drug.

Used for pregnant and lactating women

indications for treatment of Alfuzosin is not related to women.

The effect of drugs on driving and operating machinery

There is no data on the effect of the drug on the ability to drive and operate machinery. Unwanted effects such as dizziness, dizziness, dizziness, headache and hypotension may occur, especially when starting to use the drug. Be cautious when driving and operating machinery.

Drug interaction

Do not combine alfuzosin with other anti -hypertension drugs alpha receptor blockers such as prazosin, terazosin because it can cause very heavy posture lowering.

Be cautious when combining alfuzosin with other anti -hypertension drugs because of the overcrowding risk of hypotension.

Active inhibitors of cytochrom paso isoenzyme CYP3A4 such as ketoconazole, otraconazole, ritonavir may increase the concentration of alfuzosin in the blood.

Atenolol when used simultaneously with alfuzosin may increase the concentration of plasma of both drugs.

diltiazem when simultaneously used with alfuzosin may increase the concentration of plasma of both drugs.

cimetidine may increase plasma concentrations of alfuzosin.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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