Grandaxin 50mg Egis treatment for mental illness (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Tofisopam

Ingredient

Composition information	Content
Tofisopam	50mg

Uses

indications

Grandaxin 50mg drug is indicated in the following cases:

Treatment of mental illnesses (neurological) and entities with anxiety, plant disorders, lack of vitality and/or motivation, indifference, fatigue, depression.

Treatment of fake angina symptoms. Grandaxin 50mg when muscle relaxants are contraindicated, such as in mechanical diseases, muscle disease and muscle atrophy. The exact mechanism of effect of the drug is not known much. Tofisopam is different from the classic 1.4-benzodiazepin in terms of chemical structure and physical and clinical characteristics. The drug is effective in treating anxiety with plant symptoms, fatigue, indifference.

The drug has no common sleeping effects of classic benzodiazepin, nor has the activity of muscle relaxation or anti -convulsions. The drug does not weaken the intellectual and physical ability of the patient, in addition to the drug has a mild stimulating activity.

Tofisopam has very low toxicity, and only has mild side effects. There is no physical or mental dependence whether it is long -term treatment.

pharmacokinetics

absorption:

Tofisopam is quickly absorbed in the digestive system. The maximum concentration in plasma is achieved within 1 - 1.5 hours.

Distribution:

50% of the drug is attached to the protein of plasma.

Metabolism:

After being absorbed by the drug is strongly metabolized in the liver (the first passing effect) by the main transformation path is to remove methyl.

Era:

About 60% of the amount of drugs introduced in the urine and 40% in the form of metabolism. Biological cancellation time is 6 - 8 hours.

Before taking Grandaxin 50mg Egis treatment for mental illness (2 blisters x 10 tablets)

How to use

Grandaxin 50mg oral drug.

Dosage

The usual dosage in adults: 1 to 2 tablets, 1 to 3 times a day (total 50mg to 300 mg per day).

If you use it sometimes, you can drink 1-2 capsules.

can start treatment at any appropriate dose. Often there is no need to increase the dose gradually because the drug is well tolerated and does not reduce alertness during treatment with Grandaxin.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

The effects of the central nervous system only appears after high doses (50-120 mg/kg of weight. These doses can cause symptoms of vomiting, confusion, coma, respiratory failure and/or seizures, seizures.

Management:

Do not vomit when the central nervous system is clearly thought. However, the stomach can be washed.

Activated carbon and laxatives can help prevent drug absorption. Flumazeil can be used (Anexate) as a antagonist, but it is best to avoid it if overdose is due to a combination of Tofisopam with 3 -round antidepressants. It is best to avoid being used when there is hypersensitivity to benzodiazepine or flumazenil, or if the patient has epilepsy.

Must monitor basic physiological parameters, along with appropriate symptomatic treatment. It is also possible to support respiration along with Flumenazil treatment for patients with respiratory failure. Do not use the central nervous system stimulants.

Hematuria treatment by additional intravenous fluids and hold patients in Trendelenburg position. If these measures do not recover normal blood pressure, dopamine or noradrenalin may be used. Disciplining and causing no benefit.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Unwanted effects (ADR) when using Grandaxin 50mg that you may encounter:

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Not determined frequency

Digestive system: Eat delicious, constipation, flatulence, nausea, vomiting, dry mouth.

Bile liver system: jaundice due to biliary stasis.

Central nervous system: headache, feeling of stress, insomnia, irritation, agitation, confusion and can cause seizures in patients with epilepsy.

Skin: Outdoor, external rash is pink, itching.

muscle system: muscle tension, muscle pain.

Respiratory system: Respiratory failure.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Grandaxin 50mg contraindications in the following cases:

Hypersensitivity to the active ingredient or other ingredients of the drug, or any other benzodiazepine.

Calms down.

History has apnea syndrome during sleep.

History has a coma.

Be cautious when using

do not take the drug in the first three months of pregnancy and when breastfeeding.

Be cautious when treating patients with chronic respiratory failure, or in a history of acute respiratory failure.

It is very cautious when using Grandaxin 50mg tablets for elderly patients, developing intelligence and people with renal and/or liver failure, because these people are more susceptible to side effects than other patients.

Medications that impair the central nervous system (such as alcohol, antidepressants, antihistamines, sedatives causing sleep, mental disorders, analgesic like opium, anesthetic): When combining these drugs with Grandaxine, it can increase the effects.

Do not take the drug in chronic mental disorders as well as in fear or obsession. Using drugs in these cases may increase the risk of suicide and have aggressive attitudes. Therefore, Grandaxine should therefore be in case of depression, and depression comes with anxiety. Be cautious when treating patients with personality loss.

Be cautious when treating patients with brain physical damage (such as arteriosclerosis).

Treatment with Grandaxin can cause seizures in patients with epilepsy.

Do not use this drug for patients with glaucoma angle.

Each Grandaxin tablet contains 92 mg of lactose. Pay attention to this when treating patients without lactose.

Advise patients to avoid alcoholic drinks during treatment with Grandaxin.

The ability to drive and operate machinery

Although Grandaxin does not cause drowsiness or sedation, the patient must not drive, operate machinery or do high -risk jobs, at least at the beginning of treatment with Grandaxin. After that, the level and time limit these activities must be decided in each case one.

Pregnancy

Tofisopam passes through the placenta. Contraindicated drugs for the first three months of pregnancy, and must assess the benefits and risks before deciding to take the drug in the later period of pregnancy.

The period of breastfeeding

The drug is discharged into breast milk, so it should not be used during breastfeeding.

Interactive drug

Medications that impair the central nervous system (such as painkillers, anesthetics, antidepressant, antihistamine H1, sedation causing sleep, mental disorder): Grandaxine combination with these drugs will increase the effect of both (such as sedative effects, respiratory impairment).

Liver enzyme induction substances (alcohol, nicotine, barbiturate, epilepsy medicine): These drugs can increase the metabolism of Tofisopam. This can lead to plasma concentrations and the treatment effect of the drug reduced.

Some fungal drugs (ketoconazole, iTraconazole): These drugs can inhibit the metabolism of tofisopam in the liver, which can lead to increased plasma drug concentration.

Some medications for hypertension (clonidine, calcium channel antagonist): these drugs may increase the effect of Tofisopam. The beta blockers can inhibit metabolism, although it is not clinically important.

Digoxin: Tofisopam can increase the concentration of digoxin in plasma.

warfarin: benzodiazepin may affect the anticoagulant effect of warfarin.

disulfiram: long -term treatment with this drug can inhibit metabolism of Tofisopam.

antacids: can affect the absorption of Tofisopam. Cimetidine and omeprazole inhibit the metabolism of Tofisopam.

Oral contraceptives: can inhibit the metabolism of Tofisopam.

Alcohol: Tofisopam reduces the effect of the central nervous system of alcohol.

Storage

Temperature does not exceed 30 ° C.

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