Grinone 8% Merck gel treat disorders related to progesterone deficiency (15 tubes)

Dosage form 15 tube box
Specifications Progesterone
Ingredient Infertility, endometriosis, missing progesterone

Ingredient

Composition information	Content
Progesterone	8%

Uses

indications

Crinone 8% drug is indicated in the following cases:

Treatment of disorders associated with progesterone deficiency such as:

Infertility due to the incomplete royal period. bow.

Dynamic pharmacokinetics

gel progesterone uses vaginal lines based on the pollycarbophil distribution system attached to the vaginal mucosa and creates prolonged progesterone release (at least 3 days).

Before taking Grinone 8% Merck gel treat disorders related to progesterone deficiency (15 tubes)

How to use

Crinone 8% is pumped directly into the vagina thanks to a specially designed sealing tool.

Remove the applied tool from the wrap. Do not remove the cap at this time.

Hold the topical tools at the thick tip. Shake down as a thermometer to make sure the drug is at the end of the thin head.

Remove the lid and leave.

Application tools can be put in while you are in the sitting position or when you lie on your knee.

Gently put the thin head of the device applied to the vagina

Strongly squeeze the thick head of the applied tool to pump the gel.

Draw out and put in the trash.

Crinone 8% cover the vaginal mucosa to release Progesterone for a long -lasting effect.

Dosage

Infertility treatment due to the incomplete royal stage:

1 time pump (1,125g gel 8%) per day, starting after ovulation is recorded or arbitrary on the 18th to 21st day of the cycle.

When using in vitro fertilization, pump should pump Crinone 8% daily for 30 days if there is a pregnant subclinical evidence.

Children: Do not use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

generally 8% Crinone is well tolerated. In clinical studies, the following side effects have been recorded during treatment with Crinone 8%. Most of the side effects observed in clinical studies cannot be distinguished from common symptoms in the early stages of pregnancy.

Often:

Abdominal pain, perineum pain, headache, constipation, diarrhea, nausea, joint pain, depression, decreased sensuality, irritability, drowsiness, tension, breast pain, pain intercourse, night urination.

allergies, swelling, cramps, fatigue, pain, dizziness, vomiting, genitals.

Genital itching, agitation, forgetting, vaginal dryness, cystitis, urinary tract infections, vaginal discharge.

CRINOONE 8% side effects are similar to the side effects described in the medical document for natural progesterone, but the frequency is lower. Most of the side effects are light and transient, often lost when continuing treatment with Crinone 8%.

In addition, bleeding between the menstrual cycle (hemorrhage), vaginal stimulation and mild side reactions, as well as sensitive reactions that often manifest such as skin rashes that have been reported during the circulation of the drug. For harmful reactions recorded in the surveys after the drug circulated, the determination of frequency has not been conducted but often rarely encountered very rare.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

already know hypersensitivity to Crinone 8% (with progesterone or any other ingredient of the drug).

Vaginal bleeding has not been diagnosed.

Knowing or doubting malignant breasts or genitalia.

Acute prophyrin metabolism.

thrombosis, thrombosis disorders, cerebral flooding or patients with a history of these diseases.

miscarriage.

Be cautious when using

Precautions when indicating Crinone 8% for the following patients:

Crinone 8% should be used carefully in patients with severe liver failure.

Stop using drugs immediately if thrombosis, cerebrovascular disorders, pulmonary and retinal thrombosis.

When checking before treatment, special attention should be paid to the breast and organs in the pelvis, as well as spread vaginal cells.

In case of unexpected bleeding, as in all cases of abnormal vaginal bleeding, it is necessary to consider the cause of not function. In case of vaginal bleeding has not been diagnosed, adequate diagnostic measures should be taken.

Should notify the anatomical doctor about taking progesterone therapy when sending related tests.

Because progesterone can cause fluid retention to some extent, careful monitoring of diseases may be affected by this factor (such as epilepsy, migraine, asthma, heart or kidney dysfunction).

Patients with a history of mental depression should be carefully monitored and stopped taking the drug if depression relapses at a severity.

There has been a low reduction in glucose tolerance in a low percentage among patients using estrogen-Progestin combination drugs. The mechanism of this reduction is not clear. For this reason, diabetic patients should be carefully monitored while taking progestin therapy.

The ability to drive and operate machinery

drivers and use of machines are warned as a risk of sleepiness.

Pregnancy

In the case of mutual failure, Crinone 8% may be used in the first three months of pregnancy.

Breastfeeding period

Not used during breastfeeding.

Drug interaction

Although there is no report on interaction with other drugs, 8% Crinone is not recommended simultaneously with other vaginal preparations.

Storage

Store in closed packaging, temperatures below 30⁰C.

Other drugs

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