Griseofulvin 500mg Vidipha treatment of skin fungal diseases, hair, hair, nails, toenails (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Griseofulvin

Ingredient

Composition information	Content
Griseofulvin	500mg

Uses

indications

Griseofulvin drugs are indicated in the following cases:

Treatment of skin fungal, hair and nails including body fungus, leg fungus, thigh skin fungus, beard, scalp and nail mushrooms caused by sensitive trichophyton or ipidermophyton.

Do not use mild fungal infections or usually respond to topical antifungal drugs.

Pharmacology

Griseofulvin is an anti -fungal antibiotic taken from penicillium griseofulvum or from other penicillium.

The anti -fungal effect of Griseofulvin is first of all due to breaking the cellular structure, which should stop the middle phase of the cell. Another mechanism of action also mentioned is that Griseofulvin creates a defect DNA that is not capable of copying. Griseofulvin deposited into pre -Keratin cells to create an unfavorable environment for mushrooms to invade. The skin, hair and nails are infected with the disease replaced by healed tissues without fungal infection.

Griseofulvin inhibits the development of Trichophyton leather fungi (especially Trientum, T.tonsurans, T.mentagrophytes, T.verrucosum, T.MEGNINII, T.Gallinae, T.Schoenleinii), Microsporum (such as M.ADouin, M.Gypseum) and Epidermophyton Floccosum.

Pharmacokinetics

absorption

After drinking, Griseofulvin absorbed mainly in the duodenum, Griseofulvin micro -absorbent absorption varies from 25% to 70%.

When taking a single dose of microscopic form in an adult, the average peak concentration in the serum is 0.5 - 2microgam/ml after 4 hours Griseofulvin Microcrystelli significantly increased absorption if taken or after eating food with high fat, griseofulvin micro crystalline absorption almost completely after drinking.

Distribution

After absorbing Griseofulvin concentrated in the skin, hair, nails, liver, fat tissue and skeletal muscle.

Griseofulvin accumulated into pre -Keratin and highly affinity cells with infected tissues.

The drug is also closely linked with new keratin layers. It is possible to detect the drug in the outer shell of the horny layer immediately after drinking. The concentration of 1 microgram/g found in the skin within 4 hours after a single dose of 500 mic microcellescent form and after 8 hours is 3 micrograms/g.

If you use a dose of 500 mg and every 12 hours orally, the skin can achieve a concentration of 6 - 12 micrograms/g for 30 hours, when this dose lasts continuously for several weeks, the maintenance level is 12-25 micrograms/grams of leather and the concentration of serum will be 1 - 2 micrograms/ml.

When stopping the drug Griseofulvin in the skin faster faster in plasma. Within 2 days after stopping the drug will no longer be found in the skin and within 4 days will not be in plasma.

Griseofulvin concentration in the skin in a warmer climate in the skin in the cold climate, possibly due to the drug dissolved in sweat and then remained in the horny layer of the skin when sweat evaporates. This is also used to explain the inverse difference of drug concentration in the skin.

The highest drug concentration is measured in the outermost horny layer while in deeper layers, the drug concentration is much lower.

Elimination

Griseofulvin has half -life excreted 9 - 24 hours.

Methyl antioxidant drugs by P450 enzyme and combine with glucoronic mainly in the liver. Main metabolites 6 - Demethyl griseofulvin does not work on microorganisms.

Before taking Griseofulvin 500mg Vidipha treatment of skin fungal diseases, hair, hair, nails, toenails (2 blisters x 10 tablets)

How to use

Griseofulvin tablet tablets for oral tablets.

Dosage

adults

The usual dose in the treatment of body fungus (treatment for at least 2-4 weeks), thigh skin fungus, scalp fungus (treatment 4-6 weeks): 1 tablet/day.

The usual dose of skin fungus treatment (4 - 8 weeks of treatment), foundation mushrooms (treated from 4-6 months to 1 year): 2 tablets/day.

Children over 2 years

Take dose 10 - 11 mg/kg/day (maximum dose: 1g), can be divided into 2 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

When an overdose is needed to support gastric lavage with respiratory protection may be helpful.

There is no evidence to support active carbon, bleach or exclusion by non -body methods.

When missing overdose, the drug is required to treat symptoms and support.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using griseofulvin, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: headache (50% of patients).

digestive: anorexia, nausea. skin: urticaria, rash due to sensitivity to light, diverse erythema, blisters or measles.

Uncommon, 1/1000

Neurological: Sleeping, dizziness, fatigue, confusion, depression or stimulation, insomnia.

digestive: diarrhea, vomiting, abdominal pain, muscle spasms. Skin: The reaction is like serum, angioedema.

Rare, ADR

Neurological: visual disorders, peripheral neuritis.

digestive: stomatitis, taste disorders.

Liver: Gold eyes or jaundice (more common when taking a long or high doses). blood: leukopenia, granulocytosis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using griseofulvin you need to read the instructions carefully and refer to the information below.

Contraindicated

Griseofulvin drug contraindicated in the following cases:

Patients with porphyrin metabolic disorders, liver cell failure.

People with a history of sensitivity to the drug.

Not for pregnant women.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Griseofulvin has the potential for heavy toxicity.

When long -term treatment must be checked for kidney, liver and blood function. It is necessary to stop the drug if there is a phenomenon of granulocytosis.

griseofulvin sometimes causes sensitive reaction to light, so during the time of using the drug, patients need to avoid sun exposure. Sensitive reaction with light can worsen lupus erythematosus .

The drug is derived from penicillium species, so it has a cross -allergy to penicillin.

The ability to drive and operate machinery

Persons who often drive or operate machinery should use drugs?

There is no publication data on the effects of the drug on the ability to drive and operate machinery.

Pregnant women

Women during pregnancy should they take medicine?

Do not use griseofulvin for pregnant women or intended to become pregnant, as it can cause teratogenic or miscarriage.

breastfeeding women

Should women who are breastfeeding should take medicine?

There is no publication of the effect of the drug on breastfeeding women.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Drinking alcohol simultaneously with medicine can make the heart beat fast, flushed and sweat.

Phenobarbital can reduce the level of griseofulvin in the blood due to reducing griseofulvin absorption and causing cytochrom P450 enzyme in the liver microsom, so it is best not to simultaneously use these two drugs. If the case must be used simultaneously, the dose of griseofulvin should be divided into 3 times/day.

Coumarin anti -dynamic drugs: The effect of warfarin is reduced, may need to adjust the anti -dynamic dose when treated simultaneously and after stopping griseofulvin.

Oral contraceptives: Concomitance with griseofulvin may increase estrogen metabolism in these drugs, resulting in menstruation, increased bleeding between menstrual cycles and reduced birth control pills.

Simultaneous use of griseofulvin and theophylin increases theophylin clearance and shortens theophylin.

Starting Griseofulvin treatment in people who are taking aspirin will reduce the concentration of Salicylate in plasma.

griseofulvin and cyclosporin use simultaneously can reduce the concentration of cyclosporin in the blood.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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