Gynoflor Medinova vaginal placement treats vaginal infections (1 blister x 6 tablets)

Dosage form Box of 1 blister x 6 tablets
Specifications Lactobacillus acidophilus, estriol

Ingredient

Thành phần cho 1 viên

Composition information	Content
Lactobacillus acidophilus	100,000,000 - 10^10CFU
Estriol	0.03mg

Uses

Indications

Gynoflor drug is indicated in the following cases:

Lactobacillus recovery after local or body treatment with anti -bacterial or chemical drugs. On average, the case does not necessarily use antibacterial therapy.

ATC code: G01AX99.

Lactobacillus Acidophilus is one of the main microorganisms of vaginal bacteria in healthy women. Lactobacillus are bacteria that are not contagious and have a protective function in the vagina. They ferment glycogen reserves in vaginal epithelium into lactic acid. The acidic environment is formed (pH 3,8 - 4,5), which leads to unfavorable conditions for the occupation and development of pathogenic microorganisms and provides the optimal environment for the proliferation of lactobacillus. In addition to lactic acid, lactobacillus also produces hydrogen peroxide and bacteriocin are substances that also inhibit the growth of pathogenic microorganisms.

estriol is a hormone that is similar to endogenous estrogen, which has a specific effect on the vagina, but does not work on the lining of the uterus. The purpose of estriol in gynoflor is to ensure the proliferation and maturity of the vaginal epithelium. Vaginal epithelium increases and matures acts as a natural barrier and glycogen reserve - a nutrient for lactobacillus. In the case of hormone disorders, common in the elderly, vaginal epithelium disorders and glycogen content are reduced. Vaginal infections can also lead to vaginal epithelial damage.

Estriol is external, even with very low doses contained in gynoflor, also improving the proliferation and maturity of vaginal epithelium, thus creating optimal conditions for the recovery of vaginal lactobacillus bacteria.

Disorders or elimination of physiological vaginal bacteria can occur mainly as a result of the treatment of anti -bacterial drugs on the spot or systemic, severe systemic diseases, improper hygienic measures and vaginal infections. In a non -physiological vaginal environment, Lactobacillus is reduced in quantity or even without, and their protection function is no longer guaranteed.

Gynoflor's treatment concept is based on the restoration of vaginal bacteria through external lactobacillus, the growth and maturity of vaginal graves improved by exogenous estriol, resulting in the reproduction of the physiological balance of vaginal bacteria and vaginal epithelium.

lactobacillus acidophilus and estriol promote their effects in the spot in the vagina.

Lactose is used in the production of vaginal placement can also be fermented into lactic acid thanks to lactobacillus. The reproduction of Lactobacillus and the occupation in the vagina because these bacteria began after using this preparation for the first time.

pharmacokinetics

as soon as the vagina is in contact with the vaginal secretion, the pill begins to disintegrate and release lactobacillus as well as estriol. In vitro tests have shown that Lactobacillus continues to metabolize and cause a pH reduction within a few hours. The positive effect of estrogen created by estriol also starts quickly, proliferation and maturity of vaginal epithelium constantly improving according to the treatment process (6 - 12 days).

The absorption of estriol from Gynoflor has been studied in healthy women, after menopause, with atrophy epithelium. After putting a gynoflor single dose into the vagina, the concentration of the unmuditive estriol form (biological activity) in plasma increases above normal and the maximum estriol concentration is achieved after 3 hours. After 8 hours, the concentration of plasma of the unnecessary estriol is no longer increasing. However, after the 12th place at the end of the gynoflor treatment (1 time/day), the highest level of the estriol is not connected in plasma does not increase when compared to normal levels.

In a 12 -day treatment process, there is no estriol accumulation. The plasma concentration is recorded after placing gynoflor within the normal limit of the endogenous estriol level in women after menopause.

The concentration of estrone and estradiol in plasma is not affected by Estriol therapy, because Estriol is the end of metabolic product. Estriol is quickly excreted in urine mainly in the form of no biological activity (glucuronide, sulphate). Due to the low doses of Estriol (0.03mg), used on the spot and limited treatment time (6 - 12 days), no estriol accumulation occurs and it is difficult to occur with body estrogen effects.

Before taking Gynoflor Medinova vaginal placement treats vaginal infections (1 blister x 6 tablets)

How to use

gynoflor contains insoluble excipients, the remaining part is sometimes found in underwear. This is not important for the effectiveness of gynoflor.

In rare cases, the vagina is very dry, it is likely that the vagina is insoluble and the vagina comes back to the whole tablet. As a result, the treatment is not optimal. However, this does not cause vaginal damage. To prevent this case, it is possible to wet the vagina with a little water before being put into a very dry vagina.

Patients should use a clean towel or tape.

Patients should not use vaginal tap or vaginal washing during treatment with gynotlor.

Dosage

Dosage for restoring lactobacillus bacteria, vaginal discharge of unknown causes, cases of vaginal infections from mild to medium

1 - 2 vagina/day for 6-12 days, the vagina should be deep into the vagina in the evening before going to bed. It is best to perform in a lying position with slightly folded legs. Treatment should be stopped while menstruation and then continue to return

Dosage to treat vaginal atrophy

In the case of vaginal atrophy, the dose is 1 vaginal pellet/day for 6-12 days, then use the dose to maintain 1 vagina for 1-2 days/week.

What to do when overdose?

Side reactions due to overdose are likely to occur.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Gynoflor may occur a side effect as follows:

Systemic disorders and medication condition.

Mild itching or burning (1.6%) may be encountered immediately after placing gynoflor. In rare cases, non -tolerated reactions such as red and itching have been reported. A case of allergies to lactobacillus lyophilisate contained in gynoflor.

If you take the wrong gynoflor, there is no possibility of any side effects.

Patients should notify the doctor or pharmacist unwanted effects when using the drug.

Warnings

Contraindicated

gynoflor contraindicated in the following cases:

Hypersensitivity to the active ingredient or any ingredient of excipients.

Malignant changes (tumors depend on breasts) in the breast, uterus or vagina.

Endometritis (suspected or clearly).

Vaginal hemorrhage is unknown.

Young women who have not achieved genital maturity should not use this preparation.

Precautions when taking drugs

Read the instructions carefully before use. If you need more information, please consult your doctor.

This drug is only used by a doctor.

The ability to drive and operate machinery

does not affect.

Pregnancy

gynotlor can be used during pregnancy. However, as well as with drugs in general, it is necessary to be cautious when prescribing gynoflor for pregnant women in the first three months.

Data on a small number of pregnant people (54) shows no side effects of estriol and lactobacillus acidophilus in pregnant women or on the health of the fetus and infants. Moreover, Gynoflor has been used for over 15 years without a clear side effect.

Animal studies show the harmful effects of estriol on the fetus. However, Estriol is a specific sex hormone for humans and cannot be found in other mammals. Therefore, the toxic data from animal studies is used limited and cannot be inferred in humans.

gynoflor contains estriol only at very low doses. Recorded in women who are not pregnant after taking gynoflor for the first time, estriol level in plasma increases temporarily, while the 12th use does not record any increase. After repeated use, the concentration of estriol in plasma is normal in women after menopause.

Moreover, estriol concentration in the plasma of pregnant mothers increased by 1,000 times compared to pregnant women.

Breastfeeding period

gynotlor can be used during breastfeeding. However, like with drugs in general, it is necessary to be cautious. If necessary, please consult your doctor to consider benefits and risks.

Other special subjects (elderly, children, allergies)

No report.

Medicinal interaction

Gynoflor medicine may interact with the following drug: The drug interaction can change the ability of the drug or increase the effects of side effects. It is best to write a list of drugs you are taking (including prescription, non -prescription and functional foods) and for doctors or pharmacists. Do not arbitrarily take the drug, stop or change the dosage of the drug without the permission of the doctor, especially:

Lactobacillus acidophilus is sensitive to different anti -bacterial drugs (on the spot or the whole body). Simultaneous treatment with these drugs can lead to reduced effectiveness of gynoflor.

Food and alcohol

Please consult your doctor about taking medicine with food, alcohol and tobacco.

Health condition

Your health status may affect the use of this drug. Tell your doctor if you have any health problems.

Storage

Storage in the refrigerator (2 - 8 ° C)

Keep gynoflor at room temperature for 1-2 weeks of treatment does not affect the effectiveness of the drug.

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