H-Vacolaren medicine 20mg Vacopharm treat angina (2 blisters x 30 tablets)

Dosage form Box of 2 blisters x 30 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	20mg

Uses

indications

HVacolaren drugs are indicated for adults in supplementary therapy/support for existing treatments to treat symptoms in patients with stable angina without adequate control or non -tolerated patients with other angina treatment therapies.

Pharmacokology

Mechanism of action: Trimetazidin inhibits the beta oxidation of fatty acids by inhibiting Long - Chain 3 enzymes - ketoacyl - coa thiolase in ischemic cells, energy obtained during oxidation glucose needs to consume less oxygen than oxidative beta oxidation. Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

Pharmacological effects: In patients with ischemic heart anemia, trimetazidine acts as a metabolic substance, which helps conserve high intra -intra -intra -intra -intra -intra -intraucodus energy levels in myocardial cell. Trimetazidin has anti -anemia effect but does not affect hemodynamics.

Dynamic pharmacokinetics

trimetazidin when taken is absorbed very quickly and reaches the peak concentration in plasma before 2 hours after drinking. The maximum concentration of the drug in plasma, after using a single dose of trimetazidin 20 mg, reaches about 55 mg/ml. The equilibrium of the medication in the blood is reached from 24 - 36 hours after repeating a dose and is very stable during treatment. With a 48 -liter distribution volume, it shows the level of good diffusion of the drug to the tissues. Low protein mounting ratio, the measured value in vitro is 16%. Trimetazidin's waste sale time is 6 hours. The drug is excreted mainly in urine in the form of unprovered.

Before taking H-Vacolaren medicine 20mg Vacopharm treat angina (2 blisters x 30 tablets)

How to use

h - Vacolaren 20 mg is a oral medication. Drink with meals.

Dosage

Take 1 capsule/Irel x 3 times/day, use the same meal.

Patients with average renal impairment (creatinine clearance [30 - 60] ml/minute) and the elderly: take 1 capsule/time x 2 times/day, morning and dark, use with meals.

Be careful when calculating the dose for elderly patients because of the higher level of trimetazidine sensitivity than normal due to the decline in kidney function by age.

Children: Safety and effectiveness has not been evaluated, no data on this patient object.

What to do when using overdose?

No report.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Common

Dizziness, headache.

Abdominal pain, diarrhea, indigestion, nausea and vomiting.

rash, itching, urticaria.

weakness.

Rare

Brushing chest drum, nervousness, tachycardia, extra mind.

Aortic hypotension, hypotension, can lead to discomfort, dizziness or falling, especially in patients being treated with anti -hypertension drugs, flushing.

Unknown

Symptoms of Parkinson's symptoms (Run, slow and difficult exercise, muscle tone), unstable gait, vacuum syndrome, other relevant movement disorders, can often recover after stopping the drug.

Sleep disorders (insomnia, drowsiness).

Excavity of the acne pustules (AGEP), Evaluation. Constipation. hepatitis.

A blood cell loss, platelet reduction.

Platelets.

Instructions on how to handle ADR

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hypersensitivity to the active ingredient or any excipient is listed in the product preparation formula.

Parkinson patient, Parkinson's symptoms, tremor, vacuum syndrome and other relevant movement disorders.

Severe renal failure (creatinine clearance

Caution when using

trimetazidin can cause or worsen Parkinson's symptoms (Run, slow movement and difficulty, increase muscle tone), so patients, especially elderly patients, need regular inspection and monitoring. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as Parkinson's symptoms, irritability, tremor, unsteady gaits immediately stop using trimetazidin.

These cases are rarely occurring and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after the stop, it is necessary to consult neurologists.

There may be a self, unstable gait or hypotension, especially in patients who are taking drugs to treat hypertension (see also side effects).

Be careful when prescribing trimetazidin for patients with high sensitivity levels such as (see more dose and usage): Patients with average renal impairment and over 75 years old.

The ability to drive and operate machinery

trimetazidin can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

pregnancy and lactation

should be cautious and stop breastfeeding when needed to use trimetazidin.

Interactive drug

There has been no interaction with any drug. Trimetazidin is not a drug that causes induction nor is not a drug that inhibits the liver metabolic enzyme in the liver, which is more likely to trimetazidin that does not interact with many metabolic drugs in the liver.

Be cautious when coordinating with other drugs.

Storage

Put in a cool, dry place, avoid light, temperatures below 30⁰C.

Other drugs

Disclaimer

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