Ha Tay Best GSV solution for chronic bronchial asthma, allergic bronchitis (50ml)

Dosage form Box of 1 bottle x 50ml
Specifications Betamethasone, dexchlorpheniramine maleatamine
Ingredient Ha Tay Pharmaceutical Joint Stock Company

Ingredient

Composition information	Content
Betamethasone	3mg
Dexchlorpheniramine maleaty	24mg

Uses

Indications

Best GSV drugs are indicated in the following cases:

Treatment of allergies when needing corticosteroids: Chronic bronchial asthma, bronchitis, allergic rhinitis, atopic dermatitis, neuritis, contact dermatitis, urticaria. A synthetic corticosteroid, has a very powerful glucocorticoid effect, accompanied by negligible mineralocorticoid effects. 0.75mg of betamethasone has an anti -inflammatory effect equivalent to about 5mg of prednisolone. Betamethasone has anti -inflammatory, anti -rheumatic and anti -allergic effects. Oral drugs to treat many diseases need to be prescribed corticosteroids, except for adrenal insufficiency, prefer hydrocortisone and supplement fludrocortisone. Due to less mineralocorticoid effect, Betamethasone is very suitable in cases where the pathology that holds water is disadvantage. High doses, betamethasone has immunosuppressive effects.

Dexchlorpheniramine Maleatate is a propolamine derivative antihistamine. Dexchlorpheniramine inhibits competing with pharmacological effects of histamine (i.e. antagonist with histamine at H1 receptor).

pharmacokinetics

betamethasone

absorption

betamethasone is easy to be absorbed through the gastrointestinal tract.

Distribution

betamethasone quickly distributed into all tissues in the body. The drug through the placenta and can be exported to breast milk in small amounts. During the circulation, Betamethasone is widely linked to plasma proteins, mainly globulin, with less albumin. Synthetic corticosteroids include less spacious betamethasone with protein than hydrocortisone.

Metabolism

The corticosteroids are metabolized mainly in the liver but also in the kidneys and the issue into the urine. The metabolism of synthetic corticosteroids, including betamethasone, slower and their protein bonding is lower, which can be explained stronger than natural corticosteroids.

Elimination

Their cancellation time also tends to be longer, Betamethasone is a prolonged glucocorticoid.

dexchlorpheniramine maleaty

absorption

Birth of dexchlorpheniramine maleate is about 25 - 50% due to significant metabolized when passing through the liver for the first time. The drug reaches the maximum concentration in the blood after 2-6 hours. The maximum effect is achieved after taking 6 hours. Acting time 4 - 8 hours.

Distribution

The ratio of cohesion to plasma protein is 72%. Dexchlorpheniramine through placenta and breast milk.

Metabolism

The drug is metabolized mainly in the liver and produces methyl -original metabolites, this substance is not active.

Elimination

The drug is mainly eliminated through the kidneys and depending on the urine pH, 34% dexchlorpheniramine is excreted in a constant form and 22% in the form of methyl -original metabolites. The selling time cancel about 14-25 hours. Hepatic impairment or renal failure increase the half -life of dexchlorpheniramine.

Before taking Ha Tay Best GSV solution for chronic bronchial asthma, allergic bronchitis (50ml)

How to use

Oral drugs.

Dosage

Adults and children over 12 years old

Take 5ml/time, 4-6 hours/time, but not exceeding 30ml daily.

Children 6 - 12 years old

Take 2.5ml/time, 4-6 hours/time, but not exceeding 15ml daily.

Children 2 - 6 years old

Take 1.25ml/time, 4-6 hours/time, do not exceed 7.5ml per day.

Dosage for children and young children should rely on the severity of the disease and the patient's response rather than fully follow the dosage as prescribed by age, body weight or body area.

Gastrointestinal symptoms may be mitigated if taking medicine with food or milk.

After reaching the desired response, it is necessary to reduce the dose with small steps until the lowest level can be maintained to be fully clinically met. Need to stop the drug as soon as possible.

Patients need to be monitored continuously on signs that adjust the dose is necessary, such as the remission or drama of the disease and stress (surgery, bacterial infection, trauma).

When long -term treatment, Betamethasone is gradually gradually gradually gradually stepped. Before the beginning of the treatment is prolonged, it is necessary to conduct tests in all patients the basic levels of electrocardiograms, blood pressure, lung X-ray and spine, glucose tolerance tests and the function of the hypothalamus axis-yen-adrenal.

It is also necessary to conduct an X-ray of the upper gastrointestinal tract of a patient who is prone to gastrointestinal disorders. During prolonged treatment, it is necessary to periodically evaluate height, weight, X-ray of the lungs and spine, hematology, electrolytes, glucose tolerance, science and blood pressure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The effectiveness of peritoneal jurisdiction has not been seen in cases of overdose.

Overdose treatment includes symptomatic treatment and supportive treatment. Do not use stimulants. Hypertension may be used to treat hypotension. The seizures are best treated with medications that reduce short -term active effects like Thiopental. Maintain adequate water supply and control electrolytes in serum and urine, paying special attention to the balance of sodium and potassium. Treatment of electrolyte imbalance if necessary.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Best GSV, you may experience unwanted effects (ADR).

Treatment with prolonged betamethasone may experience the following harmful reactions:

Water disorders and electrolytes: Keep sodium, potassium loss, alkaline hypotension, water retention, congestive heart failure on sensitive patients, high blood pressure.

muscle and muscle: muscle weakness, muscle disease, reduced muscle mass, increased symptoms of myasthenia gravis in severe myasthenia gravis, osteoporosis, broken spine, sterile thigh bone and arm bone, broken bones of long bones, ligament broken. digestive: gastric ulcer can cause perforation and hemorrhage later, pancreatitis, bloating, esophageal ulcer. Skin: Slows wound healing, skin atrophy, delicate skin, hemorrhagic spots and bruises, floating rash on the face, increasing sweating, false tests in the skin, reactions such as allergic dermatitis, urticaria, nerve angiema. nerve: convulsions, increased intracranial pressure along with thorny gai (fake brain tumor) usually after long -term treatment, dizziness, headache.

Endocrine: abnormal menstrual periods, Cushing -like syndrome, children's retardation or decline in the development of the embryo inside the uterus, the non -metal response of the adrenal and pituitary gland, especially in stress stages such as trauma, surgery or disease, reducing carbohydrate tolerance, revealing the symptoms of potential diabetic diabetic, increasing insulin or diabetic agents Road.

Eye: cataracts under bags, increased internal pressure, glaca, convex eye. Metabolism: Nice nitrogen balance due to catabolism of protein.

Mental: refreshing, suspended feeling, severe depression to real mental manifestations, personality changes, easily stimulated, insomnia.

The most harmful effect with dexchlorpheniramine maleat: Sleep, headache, dry mouth, dry nose, dizziness, weakness, digestive disorders such as anorexia, nausea, vomiting, constipation, diarrhea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Best GSV drugs contraindicated in the following cases:

Hypersensitivity to betamethasone and sulfit or any ingredients of the drug.

Prisable when using

Patients with corticosteroids should be informed to notify the doctor when experiencing any infection, or signs of infection (for example, fever, cough, urination, muscle pain) or surgery when taking the drug for a long time, or within 12 months after stopping treatment, to adjust the dose or use it again if necessary.

Corticosteroids must be used with corticosteroids for elderly patients, sick, hypothyroidism or cirrhosis, myocardial infarction, asthma, mental patients, high blood pressure, congestive heart failure, muscle weakness, which uses anti -cholinesterase drugs, thromumes disorders of kidney impairment, osteoporosis, herpes Simple contamination in the eye, increased intraocular pressure, seizures disorders.

Use carefully in menopause because of the tendency of osteoporosis.

Do not use corticosteroids for people with mouth ulcers, unless the cases are lives. Caution should be used for patients with excess inflammation, ulcerative colitis, intestinal connection.

Do not use this medication for patients with viral infections or bacterial infections without controlled by antibiotics, unless life -threatening.

Use preventive medicine is necessary in the regime of patients with a history of working.

If possible, avoid prolonging the pharmacocorticoid pharmaceutical doses for children, as the drug may slow down the bone development. When required for prolonged treatment, careful monitoring of children and development.

High doses of glucocorticoids for children can cause acute pancreatitis leading to organs damage.

betamethasone can destroy pregnancy when used for pregnant women.

Mothers need to be told not to breastfeed when the mother uses the usual dosage of Betamethasone.

Betamethasone may cause negative results in Nitroblue Tetrazolium test to test system infection, and can prevent reactions to the skin test and cause difficulty monitoring the response to patient treatment of patients with hypothyroiditis.

Use cautiously for patients with glacoma closed angle, pyloric obstruction - duodenum, prostate hypertrophy or obstruction of the bladder neck, diabetes, muscle diseases caused by steroids, epilepsy.

This drug can cover the clinical symptoms of infection.

Using long -term drugs can prevent antibodies from infection.

Avoid stopping treatment suddenly when using long -term drugs.

Using this long -term drug can cause water opaque under the subsequent bags, glaucoma can lead to damage to the optic nerve and increase the occurrence of fungal or secondary viruses in the eye.

Use caution in congestive heart failure because there may be sodium accumulation.

Due to the ingredients of drugs that have tartrazine, caution can cause allergic reactions.

The ability to drive and operate machinery

Use carefully when driving and operating machinery, because the antihistamine component in the drug can cause drowsiness, dizziness and weakness.

Pregnancy

Not for pregnant women.

Breastfeeding period

Do not use for breastfeeding women.

Drug interaction

betamethasone

Concentrated with phenobarbital, phenytoin, rifampin or ephedrine may increase corticosteroid metabolism, thus reducing the treatment effect.

Patients taking both corticosteroids and estrogen should be monitored for corticoid effects.

Concentrated use of corticosteroids with diuretics that causes potassium loss can lead to hypokalemia. Concomitant use of corticosteroids with heart glycosides may increase the likelihood of arrhythmia or Digitalis poisoning that comes with hypotension, which can promote the possibility of potassium loss caused by amphotericin b.

Simultaneous use of corticosteroids with anticoagulants of Coumarin may increase or decrease the anticoagulant effect, may need to adjust the dose.

The effect of nonsteroidal anti -inflammatory or alcoholic combination with glucocorticoids may increase the rate or severity of stomach ulcers.

corticosteroids can reduce the concentration of salicylate in the blood. Be careful when combined with acetylsalicylic acid in the case of reducing blood prothrombin.

may need to adjust the dose of diabetes when using corticosteroids for people with diabetes.

Simultaneous treatment with glucocorticoid can inhibit response to somatotropin.

dexchlorpheniramine maleaty

Monoamine oxidase inhibitors (MAII) prolonged the effects of antihistamine anti -histamine drugs, which can cause severe hypotension.

Concentrated with alcohol, antidepressants tricyclic, barbiturate or central nervous system inhibitors can increase the sedative effect of dexchlorpheniramine.

The effect of oral anticoagulant drugs may be inhibited by antihistamine drugs.

Storage

In a dry place, temperatures below 30ºC.

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