Ha Tay Terpincold medicine reduces dry cough and cough due to neck itching (6 blisters x 15 tablets)

Dosage form Box of 6 blisters x 15 tablets
Specifications Terpin hydrate, codeine

Ingredient

Composition information	Content
Terpin Hydrate	100mg
Codeine	15mg

Uses

indications

Terpinco drugs are indicated in the following cases:

Reduce dry cough and cough due to neck itching in adults.

Codeine has a reduction effect due to the direct effect on the center of the cough in the brain, Codeine dries the respiratory discharge and increases the slope of bronchial secretions. Codeine is not enough to reduce the cough. Codeine is a cough medicine in case of dry cough.

The mechanism of action of a combination of cough reduction and an unclear phlegm.

Dynamic pharmacokinetics

codeine

absorption: Good absorption through the digestive tract. After drinking, the concentration of Codeine peak in the blood is achieved after 1 hour.

Distribution: through the placenta and distribution into breast milk.

Metabolism: Codeine is metabolized in the liver by reducing methyl (at O-and N-methyl position in the molecule) to form morphine, norphorphin and hydrocodon. The transformation into indirect morphine is influenced by Cytochrom P450 Isoenzyme CYP2D6 and this effect is very different due to the effects of the gene structure.

Elimination: Half lifetime elimination is 3-4 hours after drinking. Codeine and metabolic products are excreted mainly through the kidneys and into urine in the form of urine in the form of an associated with glucuronic acid.

terpin hydrate

The drug is well absorbed through the gastrointestinal tract.

Before taking Ha Tay Terpincold medicine reduces dry cough and cough due to neck itching (6 blisters x 15 tablets)

How to use

oral tablets. Can drink when hungry or full. Take the tablet with a glass of water.

Dosage

Adults: 1 - 2 tablets, every 6 hours if needed, no more than 8 tablets/day.

Elderly or people with liver failure: Half -dose adults.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Signs in children (toxic threshold: 2 mg/kg single dose of codeine): reducing breathing, convulsions, facial edema, urticaria rash, urinary retention.

Overdose: Respiratory support, Naloxon intravenous injection in severe cases.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

The drug can cause constipation, drowsiness, dizziness, nausea, vomiting.

Patients should be closely monitored and if detected any abnormal signs, should stop immediately.

If there is any unwanted effect of the drug becomes serious, or the unwanted effect is not listed above, tell your doctor or pharmacist.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Terpinco drugs contraindicated in the following cases:

allergies to any ingredients of the drug. Morphin (buprenorphin, nalbuphin, pentazocin).

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Do not use cough treatment with phlegm. In case of not decreasing symptoms, do not increase the dose but need to re -evaluate the condition. For sports athletes.

Metabolic through CYP2D6

Codeine is converted into morphine (active metabolites) through the enzyme near CYP2D6 in the liver. If part or all of this enzyme is deficient, the patient will not achieve appropriate treatment effect. It is estimated that up to 7% of the white population may lack this enzyme. However, if the patient has a strong or super -fast metabolic gene, the risk of harmful reactions caused by opioid poisoning even in the common prescription dose. These patients have the ability to convert codeine into morphine faster, leading to higher serum morphine levels than expected.

The common symptoms of Opioid poisoning include consciousness, drowsiness, shallow breathing, pupils, nausea, vomiting, constipation and anorexia. In serious cases, symptoms of circulatory and respiratory decline may appear, being life -threatening and very dangerous when causing death.

The estimated ratio of people carrying drug metabolism via CYP2D6 super fast in different races is summarized in the table below:

racial ratio percentage% Á 1.2%to 2% Europe 1% to 2%

Codeine is not recommended for use in children with respiratory function, including neuromuscular disorders, severe heart or respiratory diseases, upper and lung respiratory infections, multiple trauma or have just undergone major surgery. These factors can worsen the symptoms of Morphin poisoning.

Colonel: In the composition of the drug containing nipagin (0.04mg/tablet), Nipasol (0.02mg/tablet) can cause sensitive reactions to some people, so it should be cautious with patients with atopic allergies to this component.

The effect of the drug on the ability to drive and operate machinery

Drugs that cause drowsiness, so it can affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnancy

Do not use.

codeine:

The first 3 months of pregnancy: Animal studies have shown the teratogenic effect of Codeine. In clinical studies, the research results in a small number of pregnant women seem to have excluded the monster effect of Codein.

Terpin: Clinically, terpin spend has the effect of malformation in infants.

However, this research has not excluded the risks. Therefore, to prevent the risk of this drug should not be used during pregnancy.

Breastfeeding period

Contraindications. Codeine secretion into breast milk; Some cases of reduced respiratory energy and respiratory failure in breastfed babies after drug treatment containing codeine have been described.

Drug interaction

drug interactions can affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Morphin -operating owner (buprenorphin, nalbuphin, pentazocin): reduce the effectiveness of Codeine by blocking the competition of receptors, and increasing the risk of detox syndrome. Avoid drinking alcoholic and alcoholic beverages containing alcohol.

Storage

Keep the medicine in a closed box, out of the reach of children. Store drugs at room temperature, dry place, avoid direct light, temperature below 30C.

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