Hafixim 100 Kids DHG powder for infection treatment (24 packs)

Dosage form Box of 24 packs x 1.5g
Specifications Cefixime

Ingredient

Thành phần cho 1.5g

Composition information	Content
Cefixime	100mg

Uses

Indications

Hafixim 100 Kid (Cefixim) is indicated in the following cases:

Infections caused by sensitive bacteria, including:

otitis media caused by Haemophilus Influenzae, Moraxella CatVrhalis, Streptococcus Pyogenes.

Sore throat and tonsils caused by Streptococcus Pyogenes.

Acute bronchitis and exacerbation of chronic bronchitis caused by Streptococcus Pneumonia or Haemophilus Influenzae or Moraxella Catatrhalis.

Pneumonia is suffering from a mild and medium -sized body.

Inventidable urinary tract infections caused by E. coli or Proteus Mirabilis. Some cases of nephritis - pyelonephritis and urinary tract infections have complications caused by sensitive Enterobacteriaceae, but the treatment results are worse than cases of uncomplicated urinary tract infections.

Inhabited gonorrhea caused by Neisseria Gonorrhoeae, typhoid caused by Salmonella Typhi, the disease caused by sensitive shigella.

Need to isolate bacteria and make antibiotics. Antibiotics may be used before the results of antibiotics if there is suspected pathogens, but as soon as there is antibiotic results, it is necessary to adjust according to that result. The drug has a bactericidal effect. Cefixim's bactericidal mechanism is similar to other cephalosporins: attached to target proteins (penicillin -mounted proteins) that inhibit mucopeptide synthesis in bacterial cell walls. The bacterial Cefixim resistance mechanism is to reduce Cefixim's affinity for target protein or reduce the permeability of bacterial cell membranes for drugs.

Cefixim has high sustainability with the hydrolysis of beta-lactamase encoded by the gene located on plasmid and chromosom. Sustainability with beta-lactamase of Cefixim is higher than Cefaclor, Cefoxitin, Cefuroxim, Cephalexin, Cephadin.

cefixim works both in vitro and clinically with most of the strains of the following bacteria:

Gram - positive bacteria: Streptococcus pneumonia, Streptococcus pyogenes. Mirabilis, Neisseria Gonorrhoeae (secretion or no secretion of penicilinase).

Gram - positive bacteria: Streptococcus agalactiae. Salmonella spp, Shigella spp, Citrobacter Amalonaticus, Citrobacter Diversus, Serratia Marcescens.

pharmacokinetics

After taking a single dose of Cefixim, 30-50% of the dose is absorbed through the digestive tract, regardless of or after or after meals. The sale time is usually about 3 to 4 hours and may last for kidney failure. About 65% Cefixim in the blood is attached to plasma proteins. Cefixim passes the placenta.

The drug may reach relatively high concentrations in bile and urine. About 20% of oral doses are eliminated in the form of unchanged urine within 24 hours. Up to 60% of oral doses are not passed through the kidneys. The drug is not equal to the hemolysis.

Before taking Hafixim 100 Kids DHG powder for infection treatment (24 packs)

How to use

Mix medicine with just enough water (about 5 - 10ml of water for 1 pack), stir before drinking.

Drink before or after meals. Drink right after mixing into a drink.

Dosage

The treatment time depends on the type of infection, so it will last 48 - 72 hours after the symptoms of infections have gone. The usual treatment period is 5 - 10 days (if due to the streptococcus group A, Beta hemolysis must be treated for at least 10 days to prevent heart disease), lower respiratory infections and otitis media need treatment for 10-14 days.

The efficiency and safety of Cefixim in children under 6 months of age has not been established.

Children over 6 months to 12 years old

Use 8mg/kg of body weight/day, can be used once a day or divided into 2 times, each time 12 hours apart.

Adults and children over 12 years old

Use 400mg/day, can be used once a day or divided into 2 times, each time 12 hours apart.

Uncomplicated gonorrhea caused by Neisseria Gonorrhoeae (including beta-lactamase strains)

Take the only dose 400mg.

Dosage higher than 800mg is also used to treat gonorrhea.

Adjust the dose when kidney failure

Adults have creatinin clearance 21 - 60ml/minute cefixim doses 300mg/day, if creatinine clearance

or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Because there is no specific treatment, it is mainly symptomatic treatment. When symptoms of overdose, stop immediately and handle as follows: Gastric lavage, anti -convulsions may be used if clinical indications. Because the drug is not eliminated by hemolysis, no dialysis or peritoneal filter.

What to do when forgetting 1 dose? Do not use additional drugs to compensate for the forgotten dose to avoid overdose.

Side Effects

When using Hafixim 100 Kid (Cefixim), you may experience unwanted effects (ADR).

Common

Digestive: digestive disorders such as diarrhea, abdominal pain, nausea, vomiting, flatulence, not delicious, dry mouth.

Nervous system: headache, dizziness, restlessness, insomnia, fatigue.

Hypersensitivity: Red rash, urticaria.

Less

Digestive: severe diarrhea caused by Clostridium difficile and fake colitis.

Systemic: Anaphylaxis, angioedema, Stevens - Johnson syndrome, diverse roses, poisoned epidermal necrosis.

Hematology: A reduction of platelets, leukocytes, white blood cells, hemoglobin and hematocrite levels. liver: hepatitis and jaundice, temporary increase AST, ALT, alkaline phosphatase, bilirubin and LDH.

kidney: Acute renal failure, hypernodenum nitrogen non -protein and temporary plasma creatinine levels.

Other cases: inflammation and vaginal candidiasis.

Rare

Hematology: Prothrombin time is prolonged.

Body: convulsions.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hafixim 100 Kid (Cefixim) contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Patients with a history of hypersensitivity to betalactam antibiotics.

Be cautious when using

The reactions that occur on the skin such as poisoned epidermal necrosis, Stevens - Johnson syndrome, diverse roses include anaphylaxis, should stop using Cefixim and treatment with appropriate measures.

For patients with a history of allergies to penicillin and cephalosporin.

Be cautious for people with hemolytic anemia.

Needs to reduce the dose for people with renal failure, including patients dialysis outside the kidneys due to plasma cefixim concentrations in patients with higher renal impairment and longer than those with normal kidney function.

For children under 6 months old, so far there is no data on the safety and effectiveness of Cefixim.

Be cautious when using Cefixim in people with a history of gastrointestinal diseases and colitis, especially when used for prolonged use, because there may be excessive risk of developing anti -drug bacteria, especially Clostridium difficile in the intestine, causing severe diarrhea, need to stop the drug and treat with other antibiotics (metronidazol, vancomycin, ...). In addition, diarrhea for 1-2 days is mainly due to the drug, if mild does not need to stop the drug. Cefixim also changes the bacteria in the intestine.

For the elderly: no dose adjustments, unless there is impaired renal function (creatinine clearance

The ability to drive and operate machinery

Precautions when operating machinery, driving train, high -class people and other cases.

Pregnancy

There is no evidence of the harmful effects of Cefixim on the fetus, so only use Cefixim for pregnant women when necessary.

Breastfeeding period

No CEFIXIM reports are distributed into breast milk or not, so it should be considered stopping breastfeeding during the time the mother uses the drug.

Drug interaction

Probenecid increases the peak and AUC concentration of Cefixim, reduces the clearance of the kidney and the distribution of the drug.

cefixim increases the effects of anticoagulants (warfarin) and increases the concentration of carbamazepin in the blood when used simultaneously.

Glucose test in urine with clinitest, benedict solution, fehling solution can give a fake positive result when the patient uses Cefixim.

Coombs test may give false positive results during treatment with Cefixim.

Nifedipin when taken with Cefixim increases the bioavailability of Cefixim manifest by increasing the peak and AUC concentration.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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