Halozam Hasan treats cerebrovascular disorders, mental impairment (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Piracetam, Cinnarizine

Ingredient

Composition information	Content
Piracetam	400mg
Cinnarizine	25mg

Uses

indications

Halozam drugs are indicated in the following cases:

Cerebral vascular disorders;

impaired mental function; Increasing brain resistance to oxygen deficiency, improving memory, concentration, intellectual thinking ability ... The combination of reasonable dosage creates the advantages: no irritation, no drowsiness, can be used for children from 5 years old.

piracetam:

Piracetam (derivative of the amino-butyric gamma acid, GABA) is considered a substance that has a manic effect. The main effect of drugs called Hung Tri is to improve learning and memory. In normal people and people with impaired function, Piracetam directly acts on the brain to increase the activity of the brain area (the brain area is involved in the mechanism of awareness, study, memory, alertness and consciousness).

Piracetam acts on some neurotransmitters such as acetylcholin, noradrenalin, dopamin. The drug can change the neurotransmitter and contribute to improving the metabolic environment so that the cells work well.

On experiments, Piracetam works against metabolic disorders due to ischemia by increasing brain resistance to oxygen deficiency. The drug has no effect on sleep, sedation, resuscitation, analgesic, nervous or neuron as well as no GABA effect.

Piracetam reduces the ability to converge platelet and in case of abnormal erythrocytes, the drug can cause red blood cells to restore deformation and the ability to move through capillary. The drug has anti -vibration effect.

cinarizin:

cinarizin is an antihistamine H1. The majority of H1 antihistamine drugs also have anti -secretion effects of acetylcholin and sedation. H1 antihistamine drugs can block receptors at the end of the vestibular and inhibit the activation of histamine and acetylcholine secretion.

cinarizin is also a calcium antagonist. The drug inhibits blood vessel muscle muscle contraction by blocking calcium channels.

cinarizin is also used in vestibular disorders.

pharmacokinetics

piracetam:

When taking oral medication is absorbed quickly and almost entirely in the digestive tract. Bioions reach nearly 100%. Absorption of drugs does not change during long -term treatment.

Piracetam is distributed into all tissues and can be through blood - brain, placental barriers and membranes used in kidney. The drug has high concentrations in the cerebral cortex, frontal lobe, top lobe, occipital lobes, cerebellum and base core.

Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact. Piracetam clearance coefficient of the kidney in normal people is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine. If the kidney failure, the selling time increases: In people with complete renal failure and not recovering, this time is 48 - 50 hours.

cinarizin: After drinking, cinarizin achieves peak concentration in plasma from 2 to 4 hours. After 72 hours, the drug still eliminates urine.

Before taking Halozam Hasan treats cerebrovascular disorders, mental impairment (10 blisters x 10 tablets)

How to use

Take oral use. Should take medicine after meals.

Dosage

Do not take medicine for more than 3 months.

Adults: 1 - 2 capsules 3 times/day, for 1-3 months.

Children: 1 - 2 capsules x 1-2 times/day.

Patients with renal impairment: When the clearing coefficient of creatinine is below 60 ml/minute (serum creatinine above 1.25 mg/100 ml), the dose adjustment is required:

Creatinin clearance coefficient 60 - 40 ml/min, serum creatinine 1.25 - 1.7 mg/100 ml: should only use 1/2 normal dose.

Creatinine clearance coefficient 40 - 20 ml/min, serum creatinine 1.7 - 3.0 mg/100 ml: Use 1/4 normal dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

No report on overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Halozam, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: Fatigue.

digestive: digestive disorders, nausea, vomiting, diarrhea, abdominal pain, abdominal distention. nerve: restlessness, prone to agitation, headache, insomnia, sleep.

Other: sweating, allergic reactions.

Uncommon, 1/1000

Body: dizziness, weight gain.

digestive: dry mouth. nerve: Run, sexual stimulation.

Rare, ADR

Neurological: Symptoms of outsiders in the elderly or when long -term treatment.

cardiovascular: reducing blood pressure.

Very rare, ADR

Skin reaction, light sensitivity.

Instructions on how to handle ADR

Can reduce the side effects of the drug by reducing the dose.

Must stop the drug when the disease is worse or the symptoms of extracurricular symptoms are available for long -term treatment for the elderly.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Halozam drugs contraindicated in the following cases:

Hypersensitivity to piracetam, cinarizin or other ingredients of the drug.

Severe renal failure, hemorrhage stroke, porphyrin metabolic disorders, Huntington disease, liver failure.

Be cautious when using

avoid drinking alcohol during medication.

Patients with pressure in the eyes, Parkison.

Pain can cause pain in the epigastric area, should take medicine after meals to reduce the stomach irritation.

The drug can cause chicken sleep, to avoid jobs that need alertness.

Avoid taking long -term drugs in the elderly, because it can cause increased or appearing foreign symptoms, sometimes combined with depression in prolonged treatment. Be careful when taking medication for patients with renal impairment. Need to monitor kidney function in these patients and the elderly.

The ability to drive and operate machinery

avoid using while driving and operating machinery.

Pregnancy

Because the drug can be through the placenta, this drug is not allowed for pregnant women.

breastfeeding period

Because the medication is excreted in milk, it does not use this medication for nursing women.

Interactive drug

Concentrated with central nervous system inhibitors, three -round antidepressants or alcohol will increase the sedative effect.

The drug may increase the side effects of antihypertensive drugs, varicose veins, some anticoagulants, thyroid hormones and can cause tremor.

Concentrated with thyroid essence can cause confusion, stimulation and sleep disorders.

Prothrombin time has been stabilized by wafarin that can increase when taking the drug.

Storage

Where dry, less than 300C.

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