HANHANG KOREA KOREA United Treatment Treatment of primary cholestatic cirrhosis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Ursodeoxycholic acid

Ingredient

Composition information	Content
Ursodeoxycholic acid	300mg

Uses

indications

HANHOOTS are indicated in the following cases:

Support for treatment cirrhosis raw bile stasis.

Pharmacology

Ursodeoxycholic acid is a natural bile acid present with a small amount in the composition of bile acid in humans. Ursodeoxycholic acid inhibits the synthesis and excretion of cholesterol in the liver and also inhibits the absorption of cholesterol from the intestine. The drug has a little effect on inhibiting synthesis and excretion into the bile ducts of endogenous acids, and does not affect the excretion of phospholipids into the bile.

Dynamic pharmacokinetics

Ursodeoxycholic acid absorb the gastrointestinal tract after drinking and undergo a liver -intestinal cycle. Partly combined in the liver before excreting bile. Under the effects of intestinal bacteria, the drug in the form of free and combined form undergo 7A-dehydroxy chemical process forming lithocholic acid, partly eliminated through feces, the rest is absorbed. Mainly combined and sulfate in the liver before eliminating stool.

Before taking HANHANG KOREA KOREA United Treatment Treatment of primary cholestatic cirrhosis (10 blisters x 10 tablets)

How to use

drink with water.

Dosage

Treatment of primary cholestatic cirrhosis

The elderly and the elderly: The usual dose is 10 - 15 mg/kg/day, divided into 2-4 times/day.

Dissolve gallstones

Adults and the elderly: The usual dose is 6 - 12 mg/kg/day, drink once before going to bed or divided into 2-3 times. Dosage may increase to 15 mg/kg/day in obese patients, if necessary.

Treatment time can last up to 2 years depending on the stone. When the gravel has melted, continue to use in 3 months.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In general, unusual overdose symptoms do not occur because the absorption of ursodeoxycholic acid decreases gradually with increasing dose and so the drug is eliminated in more stool.

There is no need for special treatments, if diarrhea requires rehydration and electrolyte balance.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using homan drugs, you may experience unwanted effects (ADR).

Gastrointestinal disorders : Ursodeoxycholic acid can cause nausea, vomiting, diarrhea, discomfort in the abdomen, abdominal pain, constipation , indigestion.

Hepatic disorders: jaundice (aggravating or jaundice before). It is very rare in the case of gallstones that make them unable to dissolve with bile acid therapy and patients need surgery.

Abnormal tests: ALT increases, AST increases, alkaline phosphatase in the blood, increases in blood bilirubin, -Gt increases, increases liver enzymes, abnormal liver function testing, transaminase increases.

Disorders on skin and subcutaneous tissue: urticaria , itching, hair loss, rash.

Common disorders: fatigue, peripheral edema, fever.

The immune system disorder: Hypersensitivity to the face including face edema, urticaria, angioedema and laryngeal edema.

musculoskeletal and connective tissue disorders: muscle pain.

Nervous disorders: Dizziness, headache .

Respiratory disorders, chest and mediastinum: cough.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

anti -contraindications in the following cases:

Patients with calcium stones with X -barrier.

Patients with cholecystitis or acute bile ducts.

Biliary jam (bile duct clogged or a gallbladder).

Patients often have pain from gallstones.

Patients with decreased gallbladder function of gallbladder.

Patients with hypersensitivity to bile acid or any ingredient of the drug.

Pregnant or pregnant women and nursing women.

Patients with chronic liver disease, peptic ulcer or bowel or colitis diseases.

Caution when using

In the first 3 months of treatment, parameters of liver function such as AST (SGOT), ALT (SGPT) and -GT should be monitored every 4 weeks, followed by 3 months. In addition to determining the response or non -response in patients treating primary cholestatic cirrhosis, the monitor also helps early detection of the risk of liver failure, especially in patients who are in the progressive stage of primary cholestatic cirrhosis.

To assess the progress of treatment and timely determination of gallstones, gallbladder is needed after 6-10 months of treatment.

When using the drug to treat the progressive phase of primary cholestatic cirrhosis: rarely occur unsaturated cirrhosis and patients have to stop treatment.

If diarrhea needs to reduce the dose and in case of previous diarrhea, the drug should not be used.

Patients with rare genetic problems such as galactose intolerance, lactose deficiency or malposure - Galactose should not be used.

The ability to drive and operate machinery

has not recorded the effects of drugs on driving and operating machinery.

Pregnancy

There is no sufficient data on the use of ursodexolic acid in pregnant women, especially in the first three months of pregnancy. Animal studies have shown evidence of teratogenic effects in the early stages of pregnancy. So do not use ursodeoxycholic acid in pregnant women. Should stop the drug immediately if pregnant and advise a doctor.

Women who are likely to get pregnant should only treat ursodeoxycholic acid when using gift contraception. Need to avoid pregnancy before starting treatment.

The period of breastfeeding

It is unknown whether or not Ursodeoxycholic acid can be through breast milk or not. Therefore, do not use ursodeoxycholic acid in nursing women. If necessary, ursodeoxycholic acid should be treated.

Drug interaction

should not simultaneous Ursodeoxycholic acid with activated carbon, colestyramin, colestipol or antacids containing aluminum hydroxyd and/or smectit (aluminum oxide), because these products are associated with ursodexolic acid in the intestine thus inhibit the absorption and effectiveness of the drug's absorption and effectiveness. If necessary, these drugs should be taken at least 2 hours before or after taking ursodexolic acid.

Ursodeoxycholic acid may increase the absorption of cyclosporin from the intestine. In patients who are treating cyclosporin, cyclosporin concentration should be checked and dose adjustment if necessary.

In some cases, ursodeoxycholic acid can reduce the absorption of ciprofloxacin. Ursodeoxycholic acid has been shown to reduce the peak of plasma (CMAX) and the area below the curved (AUC) of nitrendipine antagonist nitrendipine.

A interaction that reduces the effectiveness of DASSON treatment has also been reported.

Oral contraceptives, hormones and medications that reduce blood cholesterol such as clofibrate may increase gallstones, the opposite of ursodeoxycholic acid used to dissolve gallstones.

Storage

In closed packaging, avoiding light. At room temperature no more than 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.