Hanoi Collydexa Pharma treat eye pain, otitis media, acute or chronic rhinitis (5ml)
Dosage form Box x 5ml
Specifications Naphazolin nitrate, dexamethasone sodium phosphate, chloramphenicol, vitamin B2
Ingredient Hanoi CPDP Company
Ingredient
| Composition information | Content |
| Naphazolin nitrate | 2.5mg |
| Dexamethasone sodium phosphate | 5mg |
| Chloramphenicol | 20mg |
| Vitamin B2 | 0.2mg |
Uses
indications
Collydexa drugs are indicated in the following cases:
pharmacokinetics
There is no information.
Before taking Hanoi Collydexa Pharma treat eye pain, otitis media, acute or chronic rhinitis (5ml)
How to use
COLLYDEXA medicine is used to small eyes, small nose, ears.
DosageCommon dose: 2-3 drops each time, 3-4 times a day.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Overdose:
Regarding naphazolin: Poisoning due to overdose (when used on the spot is too high or wrong) can cause inhibition of the central nervous system such as cooling, slow heartbeat, sweating, drowsiness, convulsions, special coma in children.
Treatment: Symptomatic and complementary treatment.
Regarding dexamethason, chloramphenicol: There is no document noted about the case of overdose when taking the drug in the form of small eyes, nose, ears.
Regarding vitamin B2: There is no document noted about the case of overdose when taking the drug in the form of eye, nose, ears.
How to handle:
When an overdose comes to see a doctor.
What to do when forgetting 1 dose?
Side Effects
When using Collydexa, you may experience unwanted effects (ADR).
chloramphenicol
Chloramphenicol's unwanted effects may be very serious, so it must be avoided for prolonged or repeated treatment.
The most serious unwanted effect is non -regenerated anemia, no recovery of bone marrow failure, often fatal and has a frequency of about 1 in 100,000 treatment cases.
Toxicity with bone marrow occurs in two forms: depending on the dose and regardless of the dose. But the unwanted effect of the nerves depends on the dose and sometimes recovering.
CommonADR> 1/100:
Uncommon: 1/1000 Other: Hypersensitivity reaction. Rare: ADR Other: Gray syndrome in infants and children under 2 weeks of age (especially at high risk). dexamethason can cause throbbing, burning, redness or tears. Long -term use can cause glaucoma, cataracts, surface conjunctivitis, thin cornea or fraction. In addition, causing visual neurological damage, vision reduction, some other visual defects. A number of corneal calcification cases have been noted when used in patients with corneal damage. naphazolin Serious side effects occur rarely when used on the spot naphazolin at the treatment dose. Some common side effects but transient as irritating the mucosa where the contact, congestion reactions may occur when used for a long time. Some body reactions may occur. Often ADR> 1/100: Few 1/1000 Other: sweating. Rarely ADR Central nervousness: Nausea, headache, dizziness, anxiety, stress, drowsiness, hallucinations, convulsions, central neurological inhibition, psychological disease lasting. riboflavin Not yet found documents recorded unwanted effects of riboflavin when used in the form of eye drops, nose, ears. Instructions on how to handle ADR: Notify the doctor with unwanted effects when using the drug.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
contraindicated
COLLLYDEXA drugs are contraindicated in the following cases:
Perforation of ear membranes.
With chloramphenicol:
With dexamethasone sodium phosphate: virus infection (active eye herpes, fungal infection or tuberculosis infection in the eye, pus infection.
With naphazolin nitrate: People with glaucoma, closed angle glaucoma.
Before doing the iris cutting procedure in patients, there is a possibility of being closed by Glaucoma.
Be cautious when using
related to chloramphenicol: serious reactions sometimes cause death, in patients using chloramphenicol have been informed. It is necessary to treat patients using chloramphenicol at the hospital to be able to perform appropriate tests and clinical examination.
Hematology effects:
One of the most serious adverse reactions of Chloramphenicol is bone marrow inhibition. Although rare, non -regenerated anemia, eager anemia, thrombocytopenia, and granulocytosis have occurred during or after short or chloramphenicol treatment.
There are two types of bone marrow inhibitors:
The first type does not depend on the dose, inhibit the bone marrow, which leads to anemia, which does not regenerate with a mortality rate of 50% or higher, mainly due to bleeding or infection. This type of adverse effect may occur immediately after the chloramphenicol doses, but more often after stopping Chloramphenicol for a few weeks to a few months. Often reducing all peripheral blood cells, but in some cases, only one or two blood cell lines (red blood cells, leukemia, platelets).
The second type of bone marrow inhibitor is more common and has the dose dependence, often recovered after stopping the drug. This type of adverse effect is manifested by anemia, reducing mesh red blood cells, leukopenia, increasing serum iron concentration, increasing serum iron reserves. This type of adverse effect often occurs when chloramphenicol concentration in serum exceeds 25 µg/ ml or when used for large people with a dose of over 4 g/ day.
Periodically check the blood formula while using chloramphenicol. Chloramphenicol must be stopped if a grid redness occurs, leukemia, thrombocytopenia, anemia or other abnormal hematology symptoms are attributed to chloramphenicol. It is impossible to rely on peripheral blood tests to predict the inhibition of non -recovery bone marrow and non -regenerated anemia.
Gray syndrome:
This syndrome can occur when using chloramphenicol in newborn babies and newborns, most of the cases when taking the drug right within the first 48 hours of their lives.
Gray syndrome can also occur in children to 2 years of age and in babies born by mothers who have used chloramphenicol in the final stage of pregnancy or labor.
Symptoms of gray syndrome usually appear 2-9 days after the start of chloramphenicol treatment with manifestations of abdomen, abdominal disturbance, with or without vomiting, progressive purple blue, vascular collapse may accompany death puppet death may occur in a few hours.
If the chloramphenicol is stopped early, after symptoms appear, the adverse effect can reverse and recover completely afterwards. Gray syndrome is a result of too high drug concentration because young children cannot afford to combine drugs or eliminate drugs that are not in combination.
Mental effects:
optic neuritis, rarely leading to blindness, has been reported after long -term treatment of high -dose chloramphenicol. Peripheral neuritis also occurs after long -term chloramphenicol treatment.
If the optic neuritis occurs or the micro neuritis, it is necessary to immediately stop chloramphenicol.
Other caution: Avoid the use of chloramphenlcol eye drops because it can increase the sensitivity and the appearance of resistance bacteria. Do not use more than 5 days if not consult a doctor. If superinfection occurs, appropriate therapy must be conducted.Be careful to use chloramphenicol for patients with impaired kidney function and/ or liver and reduce the dose according to the corresponding proportion.
Advice doctors without improvement in symptoms after 2 days or symptoms show signs of worsening.
Patients need to be transferred to the doctor if there are the following signs:
Patients should see a doctor if there have been the following signs:
Related to dexamethasone sodium phosphate:
In people with osteoporosis or new surgery, mental disorders, peptic ulcer, cornea, diabetes, hypertension, heart failure, kidney failure, tuberculosis, it is necessary to closely monitor and actively treat those diseases if it is necessary to use dexamethasone.
Consult your doctor if you are treating depression, hyperthyroidism.
Related to naphazolin:
Only use 0.05% solution for children under 12 years old when there is a physician's instruction and monitoring.
Do not use many times and continuously to avoid severe congestion again. When using nasal drops continuously for 3 days without support, patients need to stop the medicine and see a doctor. When using naphazolin eye, if the eye is still painful or blurred after 48 hours of medication or showing signs of body absorption such as headache, nausea, lower body heat, need to stop the drug and see a doctor.
Be cautious when used for people with hyperthyroidism, heart disease, coronary artery disease, atherosclerosis, chronic asthma, hypertension or diabetes, people who are taking monoamin oxydase inhibitors.
Stop used before using myocardial sensitive anesthesia such as cyclopropan, Halothan.
Should not be used if you see side effects such as glaucoma, corneal damage, iritis.
Related to riboflavin: The lack of riboflavin often occurs without other B vitamins.
The ability to drive and operate machinery
The drug can cause blurred vision, limit vision so it is not advisable to drive or operate machinery when not visible.
Pregnancy
The safety of eye drops when used for pregnant women has not been determined. Do not use drugs during pregnancy because:
Related to chloramphenicol:
Related to dexamethason:
Related to naphazolin:
The period of breastfeeding
The safety of eye drops when used for breastfeeding women has not been determined. Do not use drugs during breastfeeding because:
Related to chloramphenicol: chloramphenicol is distributed into milk. Do not use for breastfeeding women because they can cause bone marrow failure in children. The concentration of drugs in breast milk is usually not enough to cause gray syndrome for the baby.
Related to dexamethasone: dexamethasone into breast milk and are at risk for breastfed babies.
Related to naphazolin: It is unclear whether naphazolin will be secreted into breast milk. This medication should only be used when it is really necessary.
Drug interaction
related to chloramphenicol:
chloramphenicol inhibits the cytochrom p450 enzyme in the liver, is an enzyme that is responsible for the metabolism of many drugs.
chloramphenicol can affect the metabolism of chlorpropamid, dicumarol, phenytoin and tolbutamid due to inhibition of microsom enzymes, and thus can last half a lifetime of plasma and increase the effects of these drugs; Therefore, it is necessary to adjust the dosage of these drugs.
In addition, chloramphenicol can extend the time of prothrombin in patients who receive anticoagulant therapy due to the impact of the vitamin K reproduction of intestinal bacteria.Simultaneous use of chloramphenicol and phenobarbital can lead to reduced antibiotic concentration in plasma because phenobarbital causes cytochrom P450 enzyme induction capable of destroying chloramphenicol.
When used simultaneously with iron, vitamin B12 or folic acids, chloramphenicol can slow down the response to these drugs. Therefore, if possible, Cloramphenicol should be avoided in anemia, iron, vitamin B12 or folic acid.
Because the rifampin causes microsom enzymes needed for chloramphenicol metabolism, simultaneous use of these drugs can lead to decreased chloramphenicol levels in plasma.
Should avoid simultaneous use of chloramphenicol with drugs that can cause bone marrow impairment.
Related to dexamethasone sodium phosphate:
Avoid simultaneous use of dexamethasone with the following drugs: Everolimus, Natalizumab, Nilotinib, Nisoldipin, Ranolazin, Tolvaptan, Vaccine (Living).
Increasing toxic effects: Dexamethason can increase the effects of amphotericin B, acetylcholininininiserase inhibitors, cyclosporin, lenalidomid, diuretics, natalizumab, thalidomid, nonsteroidal anti -inflammatory drugs (COX - 2 inhibitors), non -steroid anti -inflammatory drugs (non -selective) diuretics, diuretics vaccine (live), warfarin.
The effect of dexamethasone may be increased by: Aprilitant, asparaginase; Calcium channel blockers (not dihydropyridine, antifungal substances (Azol derivatives, systemic effects); CYP3A4 inhibitors (medium); CYP3A4 inhibitors (strong); estrogen derivatives; neuropr that (non -reducing); p - glycoprotein inhibitors; quinolone antibiotics; trastuzumab.
Dexamethasone can reduce the effect of CYP3A4 substrates, p - glycoprotein substrates; anti -diabetic agents; Calcitriol; Caspofungin; corticorelin; dabigatran ether; Everolimus; Isoniazid; Maraviroc; nilotinib; Ranolazin; Salicylat; Sorafenib; Tovaptan; vaccine (inactivation).
The effect of dexamethasone may be reduced by: aminoglutethimid; Barbiturate; The substances seize bile acid; CYP3A4 (strong) touch substances; induction substances P - Glycoprotein; anti -acid agents; Rifamycin, deferasirox derivatives; Primidon.
Using corticosteroid therapy may need a diet to increase the amount of potassium, vitamin A, vitamin A, C, D, folate, calorpho, zinc and phosphorus and reduce sodium.
Barbiturates, Phenytoin, Rifampicin, Rifabutin, Carbamazepin, Ephedrine, Aminoglutethimid may increase corticosteroid clearance, so it reduces the treatment effect.
corticosteroids against the effects of hypoglycemia (including insulin), antihypertensive drugs and diuretics. Corticosteroid increases the hypotension effect of acetazolamid, diuretic thiazids, carbenoxolon.
The effect of anticoagulants can increase when used with corticosteroids, so it is necessary to tighten prothrombin time to avoid spontaneous bleeding.
Salicylate clearance increases when used simultaneously with corticosteroids, so when corticosteroids are susceptible to salicylate poisoning.
Diuretics reduce potassium (e.g. thiazid, furosemid) and amphotericin B can increase the effect of reducing blood potassium of glucocorticoids.
The risk of glaucoma when combined with prolonged corticosteroid treatment with simultaneous use of antigenergic drugs, especially atropine and related active ingredients.
The risk of blurring, corneal opaque can occur in patients with injured cornea and use simultaneously with other eye -containing eye drugs.
Related to naphazolin nitrate:
Use sympathetic neuropathy -like medications as well as naphazolin for patients who are taking Monoamine inhibitors of oxidase, Mappotilin, or three -round antidepressants that can cause severe hypertension.
naphazolin is similar to other sympathetic neurological medications and reduces the effects of Lobenguan I 123.
The effect of naphazolin may increase when used simultaneously with Atomoxetin, Cannabinoid, Monoamine inhibitors of oxidase or three -round antidepressants.
There has been no report on interaction with another eye medication when used simultaneously but it is recommended to use 15 minutes when taking other drugs.
Related to riboflavin: There have been some "lack of riboflavin" in people who have used clepopromazin, imipramin, amitriptylin and adriamycin.
Storage
In a dry place, temperatures below 300C, avoid light.
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