Hapacol 250 Sinus DHG treats fever, headache, muscle aches (24 packs)

Dosage form Box of 24 packs x 1.5g
Specifications Acetaminophen, chlorpheniramine

Ingredient

Composition information	Content
Acetaminophen	250mg
Chlorpheniramine	2mg

Uses

Indications

Hapacol 250 sinus drugs are indicated in cases of symptomatic treatment of cases: fever, headache, muscle aches, osteoarthritis accompanied by runny nose, secretary mucous membrane, sinusitis due to flu or allergies to weather.

Pharmacokology

ATC code: N02B E51

paracetamol is an analgesic - antipyretic. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in people with fever, but rarely reduces body temperature in normal people.

Clorpheniramin Maleat is an antihistamine, through H1 receptor inhibition according to the competitive mechanism, inhibiting histamine activity on smooth muscles, on capillary permeability, leading to reducing or losing allergens, especially in the upper respiratory tract.

pharmacokinetic

Paracetamol absorbs quickly and almost completely through the gastrointestinal tract. The sale time is 1.25 - 3 hours. Paracetamol is N - hydroxylation by cytochrom P450 to create N - Acetyl - Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus deducted activity.

However, if you take high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver; In that situation, its reaction to the sulfhydryl group of liver protein increases, which can lead to liver necrosis. The drug is eliminated through the kidneys.

chlorpheniramin maleat is well absorbed by oral. The drug is metabolized fast and much. The drug is excreted mainly in urine in the form of constant or metabolic, the excretion depends on the pH and the urine flow. The sale time of chlorpheniramin is 12 - 15 hours.

Before taking Hapacol 250 Sinus DHG treats fever, headache, muscle aches (24 packs)

How to use

Dissolve the drug in the amount of water (suitable for babies) until effervescent.

Dosage

Children from 4 - 6 years old: Take 1 pack/time.

Every 4 - 6 hours of drink, no more than 5 times/ day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Expression of paracetamol overdose:

Nausea, vomiting, abdominal pain, symptoms of blue and purple skin, mucosa and nails.

How to handle: When paracetamol poisoning is severe, it is necessary to treat actively. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds. N - Acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N - Acetylcystein solution with water or drinks without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N - Acetylcystein with the first dose of 140 mg/ kg body weight, then give 17 more doses, each dose of 70 mg/ kg body weight every 4 hours apart.

In addition, methionine, activated carbon and/ or salted carbon.

Expression of overdose chlorpheniramin:

Sediment, inverse stimulation often central nervous system, mental rebellion, seizure, apnea, convulsions, anti -secretion effects Acetylcholin, hypertonic reaction and cardiovascular collapse, arrhythmia.

Treatment: Treatment of symptoms and supporting life function, special attention should be paid to liver, kidney, respiratory, heart and water balance. Gastric or vomiting with ipecacuanha syrup. Then, use activated carbon and bleach to limit absorption. When experiencing hypotension and arrhythmia, it should be actively treated. It is possible to treat convulsions with intravenous diazepam or phenytoin intravenously. May have to be blood transfusion in heavy cases.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hapacol 250 Sinus, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Skin and subcutaneous tissue: skin.

digestive: nausea, vomiting. kidney - Urinary disease: Kidney disease, kidney toxicity when abusing for a long time.

Blood and lymphatic system: neutropenia, reducing all bloody, anemia.

Rare, 1/10,000

Body: Hypersensitivity reaction.

Clorpheniramin:

Common, ADR> 1/100

Neurological: Sleeping, sedation.

digestive: dry mouth.

Rare, 1/10,000

Neurological: Dizziness.

digestive: nausea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Hapacol 250 sinus drugs are contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Patients with glucose deficiency - 6 - phosphate dehydrogenase.

Patients with narrow -angle glaucom patients, in acute asthma attacks, prostate hypertrophy, bladder obstruction, stomach ulcers, pyloric - duodenal blockage.

Patients taking Mao inhibitors within 14 days, up to the time of treatment with chlorpheniramin.

Lactating women.

Precautions when used

Sometimes there are skin reactions including itchy and urticaria; Other sensitive reactions include larynx edema, angioedema and anaphylactic reactions that may rarely occur. Platelets, leukopenia and all bloody hematuria have occurred with the use of P - Aminophenol derivatives, especially when used for large doses.

Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

For people with phenylceton - urinary and people must limit the amount of phenylalanin put into the body, should avoid using paracetamol with drugs or foods containing aspartam. For some hypersensitivity people (asthma) should avoid using paracetamol with drugs or foods containing sulfit.

Be careful in patients with anemia before, impaired liver and kidney function. Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking.

Clorpheniramin may increase the risk of urinary retention, especially in people with prostate hypertrophy, urinary tract obstruction, pyloric gaster, and worsen in patients with myasthenia gravis. The sedative effect of chlorpheniramine increases when drinking alcohol and when used simultaneously with other sedatives. Be cautious when used for people with chronic lung disease, shortness of breath or shortness of breath, people with glaucoma, elderly people. The risk of tooth decay when used for a long time.

For Paracetamol -containing drugs: The doctor needs to warn the patient about the signs of serious skin reactions such as Steven - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustular syndrome (AGEP).

The ability to drive and operate machinery

Do not use drugs for those who are operating machinery, train driving, higher -working people and other cases.

Pregnancy

only use the drug when really necessary.

Using chlorpheniramine in the last 3 months of pregnancy can lead to serious reactions (such as epilepsy) in newborns.

Breastfeeding period

Contraindications for breastfeeding women.

Drug interaction

Unbelievable use with the following drugs: Coumarin antifiers and indoors, phenothiazine, anti -seizure drugs (phenytoin, barbiturat, carbamazepine), Isoniazid, sedative drugs that cause sleep, alcohol and other alcoholic drinks, Monoamine inhibitors.

Storage

In a dry place, the temperature does not exceed 300C, avoiding light.

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