Hapacol 325 Flu DHG nuggets treat headaches, migraine, toothache (24 packs)

Dosage form Effervescent nuggets
Specifications Box of 24 packs x 1.5g
Ingredient Paracetamol, chlorpheniramin maleat
Indication Fever, dysmenorrhea, cold, headache, migraine, body aches, teething
Contraindication Anemia

Ingredient

Composition information	Content
Paracetamol	325mg
Chlorpheniramin Maleat	2mg

Uses

Indications

Hapacol 325 Flu drugs are indicated in the following cases:

Used to treat fever symptoms such as fever, headache, runny nose, runny nose, mild aches and pains. However, unlike aspirin, paracetamol is not effective in treating inflammation. With the equal dose calculated by grams, paracetamol has an analgesic and antipyretic effect similar to Aspirin. Paracetamol reduces body temperature in fever, but rarely reduces body temperature in normal people.

The drug acts on the hypothalamus, causing cooling, increasing heat due to vasodilation and increased peripheral blood flow. Paracetamol, with treatment, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding like when using salicylate, because paracetamol does not work on the body cycloxygenase, only affect cycloxygenase/ prostaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time.

When overdose of paracetamol, a metabolic substance is N - Acetyl - Benzoquinonimin that is toxic to the liver. Normal doses, paracetamol tolerated well, without many side effects of aspirin. However, acute overdose (over 10 g), causing liver damage to death, and poisoning cases, suicide with paracetamol has increased worrying in recent years. In addition, many people including physicians, seemingly unaware of Paracetamol's poor anti -inflammatory effects.

Clorpheniramin Maleat is an antihistamine drug, through competition inhibitors of H1 receptors of the acting cell.

pharmacokinetic

paracetamol is quickly absorbed and almost completely through the gastrointestinal tract, the peak concentration in plasma is within 30 - 60 minutes after drinking with the dose of treatment. The sale time is 1.25 - 3 hours. The drug is distributed quickly and evenly in most of the body's tissue. The drug is n - hydroxylation by cytochrom P450 and is eliminated through the kidney.

chlorpheniramin maleat absorbs well after drinking and appears in plasma within 30 - 60 minutes. The peak concentration of plasma is about 2.5 - 6 hours after drinking. The drug is metabolized fast and much, the sale time is 12 - 15 hours. The drug is excreted mainly in urine.

Before taking Hapacol 325 Flu DHG nuggets treat headaches, migraine, toothache (24 packs)

How to use

How to drink every 4-6 hours.

Dosage

Adults and children over 12 years: Take 2 packs/time, no more than 12 packs/day.

Children from 6 to 12 years old: Drink 1 pack/time, no more than 5 packs/day.

Children under 6 years old: consult a doctor.

or as directed by the physician.

Note:

Do not take the drug continuously for more than 7 days without the advice of medical staff.

Do not use paracetamol to treat pain for more than 10 days in adults and more than 5 days in children, unless the physician is instructed, because of such a lot of pain and prolonged pain may be a sign of a pathological condition that needs a physician to diagnose and supervise.

Do not use paracetamol for adults and children to treat high fever by themselves for 39.5oC), fever lasts for more than 3 days or recurrent fever, unless it is instructed by a physician, because such a fever may be a sign of a severe disease that needs to be diagnosed quickly by a physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Related to paracetamol:

Paracetamol overdose due to a single -dose or a repeated dose of a large dose of paracetamol (7.5 - 10 g per day, for 1-2 days) or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Manifestations of paracetamol overdose: Nausea, vomiting, abdominal pain, symptoms of blue -purple skin, mucosa and nails.

How to handle: When paracetamol poisoning is severe, it is necessary to treat actively. Gastric lavage is needed in any case, preferably within 4 hours after drinking. The main detoxification is the use of sulfhydryl compounds. N - Acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol.

In addition, methionine, activated carbon and/or salted carbon.

Related to chlorpheniramin:

The estimated death dose of chlorpheniramine is 25 - 50 mg/ kg body weight. Symptoms and overdose signs include: sedation, mental disorders, seizures, apnea, convulsions, anti -secretion effects Acetylcholin, cardiovascular collapse including arrhythmia, ....

How to treat: Symptomatic treatment and support, especially pay attention to the heart, respiratory, liver, kidney function, water balance and electrolyte. If the oral exceeding, treating with activated carbon should be considered if there is no contraindication (the most effective should be used within 1 hour after the overdose). When experiencing hypotension and arrhythmia, it should be actively treated. It is possible to treat convulsions by intravenous diazepam intravenously. Hematoparoology should be done in severe cases.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hapacol 325 Flu, you may experience unwanted effects (ADR).

Related to paracetamol:

Uncommon, 1/1 000

Skin: Ban.

Skin: Stevens - Johnson syndrome, poisoned epidermal necrosis, lyell syndrome, acute all -body pustules.

Unwanted effects are recorded with the frequency: common (1 - 10%), very common (≥ 10%). The frequency of other side effects after bringing the drug to the market has not been recorded.

Very common:

Central nervous system: drowsiness, drowsiness.

Common:

Central nervous system: Attention disorders, dizziness, headache. Gastrointestinal: Nausea, dry mouth. Visual: blurred vision. Other: fatigue.

Unknown frequency:

Blood and lymphatic system: Disorders of hematopoietic disorders, hemolytic anemia. Fast, arrhythmia.

Low blood pressure. and connective tissue: muscle seizures, muscle weakness.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using Hapacol 325 Flu you need to read the user manual carefully and refer to the information below.

Contraindicated

Hapacol 325 Flu drugs in the following cases:

Hypersensitivity to one of the ingredients of the drug. Monthly birth.

Precautions when using

for people with phenylceton - urinary and people must limit the amount of phenylalanin put into the body should avoid using paracetamol with drugs or foods containing aspartam. For some hypersensitivity people (asthma) should be avoided with paracetamol with drugs or foods containing sulfit. Precautions must be used in patients with anemia before, impaired liver and kidney function. Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking.

Clorpheniramin may increase the risk of urinary retention, especially in people with prostate hypertrophy, urinary tract obstruction, pyloric gaster, and worsen in patients with myasthenia gravis. The sedative effect of chlorpheniramine increases when drinking alcohol and when used simultaneously with other sedatives. Be cautious when used for people with chronic lung disease, shortness of breath or shortness of breath, people with glaucoma, elderly people. The risk of tooth decay when used for a long time.

For Paracetamol -containing drugs: The doctor should warn the patient about the signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas pustular syndrome (AGEP).

The ability to drive and operate machinery

Caution while driving and operating machinery

Pregnancy

Pregnant women: only use drugs when really necessary. Using chlorpheniramine in the last 3 months of pregnancy can lead to serious reactions (such as epilepsy) in newborns.

Breastfeeding period

Lactating women: Should consider or do not breastfeed or do not take the drug, depending on the need for the drug for the mother. Like other drugs, consult a doctor before taking the drug.

Medicinal interaction

Long -doses of high -dose Paracetamol increases the anticoagulant effect of COUMARIN and conducting indandion. Pay attention to the likelihood of serious antipyretics in patients using simultaneously phenothiazine and cooling therapy. Anti -convulsions (phenytoin, barbiturat, carbamazepin), isoniazid and tuberculosis drugs can increase the toxicity of the liver of paracetamol. Drinking too much and long alcohol can increase the risk of paracetamol toxic to the liver. Cholestyramin reduces the absorption of paracetamol (without drinking within 1 hour).

chlorpheniramine inhibits phenytoin metabolism, which can lead to phenytoin poisoning. Sedative causes sleep, alcoholic beverages can increase the effect of inhibiting the central nervous system of chlorpheniramin. Monoamine oxydase inhibitors extend and increase the anti -secretion effect of acetylcholine of antihistamines.

Storage

Storage conditions: dry place, temperature not exceeding 30 ° C, avoiding light.

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