Hapacol 650 Extra DHG drugs treat headaches, migraine, sore throat (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol, caffeine
Indication Sore throat, sinusitis, fever, dysmenorrhea, cold, headache, migraine, body aches
Contraindication Anemia

Ingredient

Composition information	Content
Paracetamol	650mg
Caffeine	65mg

Uses

indications

Hapacol 650 Extra is indicated in the following cases:

Reduce pain in pain such as headache, migraine, sore throat, dysmenorrhea, tooth extraction pain or dental procedures, toothache, muscle aches, tendons, traumatic pain, pain caused by arthritis, sinusitis, pain, colds, flu. Cafeine:

Paracetamol is an effective fever -fever. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in the fever, but rarely reduces normal heat body.

In the treatment dose, analgesic effect, antipyretic equivalent to aspirin but paracetamol has little impact on the cardiovascular system and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding. Paracetamol does not have the effect of treating inflammation.

caffeine has a slight stimulating effect on the central nervous system.

Dynamic pharmacokinetics

Paracetamol absorb quickly and almost entirely through the digestive tract. The sale time is 1.25–3 hours. Metabolic drugs in the liver and excreted through the kidneys.

Cafeine absorbs quickly through the digestive tract, the maximum concentration in plasma in successful adults achieved after 1 hour, the sale time is 3–7 hours. Cafeine is metabolized in the liver and eliminated through urine.

Before taking Hapacol 650 Extra DHG drugs treat headaches, migraine, sore throat (10 blisters x 10 tablets)

How to use

Hapacol 650 Extra oral.

Dosage

Adults and children over 12 years: take 1 capsule 3–4 times/day. The distance between two drinks is 4–6 hours. Do not drink more than 6 tablets/day.

In case of severe renal failure (Creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Expressions of overdose: Nausea, vomiting, abdominal pain, symptoms of purple blue, mucosa and nails.

How to handle:

When paracetamol poisoning is severe, it is necessary to treat actively. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds. N-acetylcysteine is effective when taking or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with n-acetylcysteine is more effective when giving the drug for less than 10 hours after taking paracetamol.

In addition, methionine can be used, activated carbon and/or salt bleach.

Caffeine overdose: rarely occurs, overdose symptoms are often insomnia, restlessness, agitation and can be delirious.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hapacol 650 Extra, you may experience unwanted effects (ADR).

paracetamol rarely causes side effects but sometimes causes allergies, skin rash, vomiting, nausea, some cases can reduce all bloody, leukopenia, anemia. May cause liver failure (due to canceling liver cells) when using high, prolonged doses.

Related to caffeine: When using high doses of caffeine can cause hypertension, falling asleep during the day. In addition, there are other unwanted effects such as nausea, vomiting, diarrhea, insomnia, headache, tremor, nervousness, anxiety.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hapacol 650 Extra is contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Patients with glucose-6-phosphate dehydrogenase deficiency.

Be cautious when using

for people with phenylceton urine and people must limit the amount of phenylalanine put into the body should avoid using paracetamol with drugs or foods containing aspartam.

For some hypersensitivity people (asthma) should avoid using paracetamol with drugs or foods containing sulfite.

Be used to be cautious in patients with anemia before, people with impaired liver and kidney function.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

When using high -dose caffeine can cause hypertension should be used cautiously in hypertension patients.

Doctors need to warn the patient about signs of serious skin reactions such as Steven -Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

only use the drug when really necessary.

Breastfeeding period

only use the drug when really necessary.

Medicinal interaction

long -term oral doses of high doses Paracetamol increases the anticoagulant effect of cooumarin and indandione derivatives.

Pay attention to the possibility of serious antipyretics in patients using simultaneously phenothiazine and cooling therapy.

Anti -seizure (Phenytoin, barbiturate, carbamazepine), isoniazid increases the liver poisoning of paracetamol.

Out and long -term drinking increases the toxicity on the liver of paracetamol.

Should avoid using with medicine or drinks with caffeine such as tea, coffee and some canned drinks.

increased waste time of caffeine when combined with antibiotics: ciprofloxacin, enoxacin, lomefloxacin, norfloxacin, ofloxacin.

Do not combine caffeine with: phenytoin, fluvoxamine, terbinafine, cimetidine, methoxsalen, birth control pills, phenylpropanolamine, ephedrine, theophylline.

Storage

Store in a dry place, avoid light, temperature below 30 ° C.

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