Hapacol CS day DHG treats fever, runny nose, nasal congestion (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol, phenylephrine
Indication Allergic rhinitis, colds, headache, stuffy nose
Contraindication Prostate hypertrophy, coronary artery disease, cardiovascular disease, bronchial asthma, anemia, narrow -angle glaucoma, hyperthyroidism

Ingredient

Composition information	Content
Paracetamol	650mg
Phenylephrine	5mg

Uses

indications

Hapacol CS Day 650/5 medicine is used to treat symptoms of fever, runny nose, nasal congestion due to flu, colds.

Pharmacokology

paracetamol is an effective analgesic - antipyretic.

The drug acts on the hypothalamic cashew center, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in people with fever, but rarely reduces normal body temperature.

Phenylephrin has the same effect as the sympathetic nerve Alpha 1, directly on the Alpha 1 -adrenergic receptor receptors as vasoconstrictor. Phenylephrin causes local vasoconstriction should reduce nasal congestion and sinuses due to colds.

pharmacokinetics

paracetamol

Absorption:

Paracetamol when taken will be absorbed quickly and completely.

Paracetamol is quickly distributed into most tissues.

Paracetamol is metabolized mainly in the liver in two main paths in the liver: associated with glucuronic acid and associated with sulfuric acid; Combined with sulfuric acid quickly saturated when taking a higher dose but still within the scope of treatment.

The saturation of the glucoronid chemical process only appears when the dose is higher, toxic to the liver. A small part (less than 4%) is trips by Cytochrom P450 to form a high reaction intermediate (N-acetyl Benzoquinoneimin), under normal usage conditions, this intermediate will be detoxified by glutathion reduction and are eliminated in urine after combined with cystein and mercapturic acid.

However, when poisoning with high doses of paracetamol, the amount of toxic metabolites increases.

Era:

Paracetamol metabolites are mainly excreted in urine, in adults, about 90%of the dose is excreted for 24 hours, mainly in the form of glucuronid complex (about 60%) and sulfate conjugate (about 30%). Under 5% is eliminated in the form of constant.

absorption: Phenylephrin abnormal absorption through the gastrointestinal tract due to metabolic right on the digestive tract.

Distribution: Phenylephrin distributed during circulation may be distributed to tissues without data associated with protein or distributed to breast milk or not

Metabolism: Phenylephrin is metabolized in the liver and intestines thanks to the enzyme monoamine oxidase (Mao).

Elimination: Excreted through urine almost entirely in the form of sulphate.

Before taking Hapacol CS day DHG treats fever, runny nose, nasal congestion (10 blisters x 10 tablets)

How to use

Hapacol CS day long tablet tablets for oral use.

Dosage

Common dose in adults and children over 12 years: 1 capsule x 2-3 times/ day.

The distance between twice taken from 4 to 6 hours.

Do not drink more than 6 tablets/ day.

What to do when overdose?

paracetamol

Poisoning caused by paracetamol overdose due to a single -dose or a large dose of paracetamol (7.5 - 10 g per day, for 1-2 days) or for long -term medication. The liver necrosis depends on the dose is the most serious toxic effect and can be fatal.

Symptoms: Nausea, vomiting, abdominal pain, symptoms of purple blue, mucosa and nails.

Handling: stomach lavage; N - Acetylcystein is an effective antidote if it starts within 10 - 12 hours after overdose, still benefits if treated within 24 hours.

phenylephrin

Doses of poisoning due to phenylephrin may be greater than paracetamol toxic doses.

Symptoms: Hypertension, headache, convulsions, brain hemorrhage, chest drums. Slow heart rate usually occurs early.

Hypertension: Hypertension can be overcome by taking alpha-adrenergic blockers like phetolamine 5-10mg intravenously, if necessary, can be repeated.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the forgotten dose and continue the calendar of Hapacol. Do not use double dose to compensate for missed dose.

Side Effects

When using Hapacol CS Day 650/5, you may experience unwanted effects (ADR).

related to paracetamol

Less:

Skin rash.

Hypersensitivity reactions.

Phenylephrin can cause tachycardia, brushing chest, restlessness, difficulty sleeping, hypertension, hallucinations, paranoia, hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hapacol CS DAY is contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Children under 12 years old.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

For people with phenylketon and people must limit the amount of phenylalanin put into the body, they should avoid using paracetamol with drugs or foods containing aspartam. Precautions must be used in patients with anemia before, impaired liver and kidney function.

Drink plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

Patients are using beta-adrenergic receptor inhibitors.

The ability to drive and operate machinery

Persons who often drive or operate machinery should use drugs?

Be cautious when used for people who are driving and operating machinery.

Pregnancy

Women during pregnancy should take medicine?

Only use drugs for pregnant women when really necessary, consideration of harm caused by drugs.

Demonstrate period

Should breastfeeding women take medicine?

Must be very cautious when taking medicine for breastfeeding women, because it is unclear whether the drug is distributed in breast milk.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

with paracetamol

Paracetamol long -dose long -dose drinks slightly increase the anticoagulant effect of COMAARIN and conducting indandion.

Anti -seizure drugs (phenytoin, barbiturat, carbamazepin), isoniazid increases the toxic liver toxic of paracetamol.

Drinking a lot of alcohol and long days increases the toxicity on the liver of paracetamol.

with phenylephrin

Mao inhibitors increase the body effect of phenylephrin.

Three -round antidepressants, Guanethidin, Atropin Sulfate, ALCALOID chicken spurs in injection, digitalis increases the effect of hypertension of phenylephrin.

The hypertension reaction has been reported when coordinating phenylephrin with cardiovascular medications.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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