Hapacol Extra DHG medicine reduces headaches, migraine (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol, caffeine
Indication Sore throat, sinusitis, fever, headache, migraine, body aches
Contraindication Anemia

Ingredient

Composition information	Content
Paracetamol	500mg
Caffeine	65mg

Uses

Indications

Hapacol Extra is prescribed in cases of pain relief in pain such as headache, migraine, sore throat, dysmenorrhea, after tooth extraction or dental procedures, toothache, muscle aches, tendons, pain due to trauma, pain caused by arthritis, sinusitis, colds, colds.

Pharmacokological

Hapacol Extra is a combination of paracetamol and caffeine.

paracetamol

paracetamol is an effective antipyretic analgesic. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in the fever, but rarely reduces normal heat body.

In the effective dose of pain relief, antipyretic equivalent to aspirin but paracetamol has little impact on the cardiovascular system and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding.

caffein

caffeine has a slight stimulating effect on the central nervous system, supports pain relief and makes it easy for muscle activity.

pharmacokinetic

paracetamol

absorption:

Paracetamol absorbs quickly and almost completely through the digestive tract.

Metabolism and elimination: Metabolic drugs in the liver and eliminate the kidneys, the sale time is 1.25 - 3 hours.

caffein

absorption:

Cafein absorbs quickly through the gastrointestinal tract, the maximum concentration in plasma in successful adults achieved after 1 hour.

Metabolism and elimination:

The drug is metabolized in the liver and eliminated through the urine, the sale time is 3 - 7 hours.

Before taking Hapacol Extra DHG medicine reduces headaches, migraine (10 blisters x 10 tablets)

How to use

Hapacol EXTRA drug used oral.

Dosage

Adults and children over 12 years: 1 - 2 capsules x 1 - 4 times/day.

Do not use more than 8 tablets/day.

The minimum distance between 2 drinks is 4 hours.

or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Paracetamol overdose

Due to a single dosage or a large dose of paracetamol (7.5 - 10 g per day, for 1-2 days) or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Expression of an overdose: nausea, vomiting, abdominal pain, symptoms of purple blue, mucosa and nails.

How to handle:

When paracetamol poisoning is severe, it is necessary to treat actively. Need to wash the stomach in all the best cases within 4 hours after drinking.

The main detoxification is the use of sulfhydryl N-acetylcystein compounds that work when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol.

Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. In addition, methionine, activated carbon and/or salt -cleaning can be used.

Overdose of caffeine

Rarely occurs, symptoms of overdose are often insomnia, restlessness, agitation and can be delirious.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hapacol Extra, you may experience unwanted effects (ADR).

paracetamol rarely causes side effects but sometimes causes allergies, skin rash, vomiting, nausea, some cases can reduce all bloody, leukopenia, anemia. May cause liver failure (due to canceling liver cells) when using high, prolonged doses.

Related to caffeine, when using high doses, caffeine can cause hypertension, falling asleep during the day. In addition, there are other undesirable effects nausea, vomiting, diarrhea, insomnia, headache, tremor, nervousness, anxiety.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hapacol Extra is contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

Be cautious when using

for people with phenylceton - urinary and people must limit the amount of phenylalanin put into the body should avoid using paracetamol with drugs or foods containing aspartam.

For some hypersensitivity people (asthma) should avoid using paracetamol with drugs or foods containing sulfit. Precautions must be used in patients with anemia before, people with impaired liver and kidney function.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

When using high -dose caffeine can cause hypertension should be used cautiously in hypertension patients.

For Paracetamol-containing drugs: The doctor needs to warn the patient about the signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, provincial-level pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

only use the drug when really necessary.

Breastfeeding period

Medicinal interaction

Long -doses of high -dose Paracetamol increases the anticoagulant effect of COUMARIN and conducting indandion.

Pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Anti -seizure drugs (Phenytoin, barbiturat, carbamazepin), isoniazid increases the liver poisoning of paracetamol.

Out and long -term drinking increases the toxicity on the liver of paracetamol.

Avoid using with medicine or caffeine such as tea, coffee and some canned drinks.

Sales of caffeine increases when combined with antibiotics: ciprofloxacin, enoxacin, lomefloxacin, norfloxacin, ofloxacin.

Do not coordinate with caffeine with phenytoin, fluvoxamine, terbinafin, cimetidin, methoxsalen, birth control pills, phenylpropanolamine, ephedrin, theophylllin.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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