Hapacol painful DHG pain relief, anti -inflammatory (10 blisters x 5 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 5 tablets
Ingredient Paracetamol, ibuprofen
Indication Fever, colds, headache, back pain, arthritis, rheumatoid arthritis, sprain
Contraindication Renal failure, bronchial asthma, coagulation disorders

Ingredient

Thành phần cho 1 viên

Composition information	Content
Paracetamol	325mg
Ibuprofen	200mg

Uses

Indications

Hapacol painful 325/200 DHG is indicated in the following cases:

Hapacol aches and pains have analgesic, anti -inflammatory effects in cases of muscle and joint pain caused by trauma, rheumatism, neuritis such as back pain, scoliosis, sprain, excessive muscle tension, fracture, dislocated, postoperative pain ... Learning

Hapacol aches and pains is an analgesic, anti -inflammatory combination from 2 active ingredients.

Paracetamol is an effective analgesic - antipyretic. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat caused by vasodilation and increasing peripheral blood flow reduces body temperature in people with fever, but rarely reduces normal body temperature. Paracetamol absorbs quickly and almost completely through the gastrointestinal tract. The sale time is 1.25 - 3 hours. Metabolic drugs in the liver and excreted through the kidneys.

ibuprofen is an nonsteroidal anti -inflammatory drug, has analgesic, antipyretic and anti -inflammatory effect. Ibuprofen inhibits prostaglandin synthetase and thus prevents prostaglandin, inflammation, pain and fever. Ibuprofen is the safest drug in nonsteroidal anti -inflammatory drugs. Ibuprofen absorbs well, the maximum concentration of the drug in plasma is achieved after 1-2 hours. Half life of the drug is about 2 hours. The drug is excreted mainly in urine.

A reasonable dosage combination of ibuprofen and paracetamol in Hapacol aches for a stronger analgesic effect and safer use than when using two separate tablets.

pharmacokinetics

There is no information.

Before taking Hapacol painful DHG pain relief, anti -inflammatory (10 blisters x 5 tablets)

How to use

oral medication. Take medicine after meals.

Dosage

Adults: Take 1-2 capsules x 2-3 times/day. Not more than 12 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The liver necrosis depends on the dose is the most serious toxic effect due to overdose and may cause death. Manifestations of paracetamol overdose: Nausea, vomiting, abdominal pain, symptoms of purple blue, mucosa and nails. When paracetamol poisoning is severe, it is necessary to treat actively. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds. N - Acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N - Acetylcystein solution with water or drinks without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N - Acetylcystein with the first dose of 140 mg/kg body weight, then give 17 more doses, each dose of 70 mg/kg body weight every 4 hours apart.

In addition, methionine, activated carbon and/or salted carbon.

Overdose and management of ibuprofen: usually symptomatic and supportive treatment. If you have overdose, it is necessary to apply the following measures to increase elimination and inactivity: gastric lavage, vomiting and diuretic, drinking activated carbon or salt bleach. If severe: hemorrhage or blood transfusion. Because the drug causes acidosis and elimination in the urine, theoretically will benefit when transmitting alkaline and diuretic.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hapacol painful 325/200 DHG, you may experience unwanted effects (ADR).

Side reactions when taking the drug rarely occur. Common side effects of ibuprofen: digestive disorders such as nausea, vomiting, indigestion, stomach pain, epigastric pain, gastrointestinal bleeding, headache, dizziness. Paracetamol sometimes causes allergies, skin rash, vomiting, nausea, some cases can reduce all bloody, leukopenia, anemia, which can cause liver failure (due to liver cell cancellation) when used in high, prolonged doses.

Risk of cardiovascular thrombosis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Hapacol painful medicine 325/200 DHG Contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

Progressive stomach - duodenal ulcer.

Hypersensitivity to aspirin or other nonsteroidal anti -inflammatory drugs.

Patients with asthma or bronchospasm, bleeding disorders, cardiovascular disease, glue, a history of stomach - duodenal ulcer, liver failure or kidney failure (glomerular filtration flow is less than 30 ml/min).

People are being treated with anticoagulants.

Patients with congestive heart failure, decreased volume of circulatory amounts due to diuretic or kidney failure.

Pregnant women in the last 3 months.

Be cautious when using

for people with phenylceton - urinary and people must limit the amount of phenylalanin put into the body should avoid using paracetamol with drugs or foods containing aspartam. For some hypersensitivity people (asthma) should be avoided with paracetamol with drugs or foods containing sulfit. Precautions must be used in patients with anemia before, impaired liver and kidney function. Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking.

ibuprofen may increase the transaminase increases in the blood, but this transformation is transient and recovered. When using the drug can cause blurred vision but will stop using the drug. Be careful when using ibuprofen for the elderly. Ibuprofen inhibits platelet capacitors so it can cause prolonged bleeding time.

For Paracetamol -containing drugs: The doctor should warn the patient about the signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas pustular syndrome (AGEP).

Risk of cardiovascular thrombosis: nonsteroidal anti -inflammatory drugs (NSAIDs), non -aspirin, using systemic tract, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear. In order to minimize the risk of adverse events, Hapacol is needed to use aches and pains at the lowest daily dosage effectively in the shortest possible time.

The ability to drive and operate machinery

Caution when driving and operating machinery because the drug can cause headaches, dizziness.

Pregnancy

should not use drugs during pregnancy, especially in the last 3 months of pregnancy.

The period of breastfeeding

The drug in breast milk is very small and negligible. Less likely to occur risks for children at normal doses with mothers.

Drug interaction

Long -term oral high -dose Paracetamol takes slightly anticoagulant effects of COMAARIN and indandion derivatives. Anti -convulsions (phenytoin, barbiturat, carbamazepin), isoniazid increases the toxic liver toxicity of paracetamol. Drinking too much and long -term alcohol can increase the risk of paracetamol toxic to the liver.

ibuprofen increases the side effects of quinolon antibiotics on the central nervous system, increasing the toxicity of methotrexate and digoxin. Used with other nonsteroidal anti -inflammatory drugs increases the risk of bleeding and peptic ulcer. Ibuprofen may increase the expression of Furosemid sodium and diuretics.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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