Hard capsules Mepraz 20mg Sanofi treat peptic ulcer, reflux esophagitis (7 blisters x 4 tablets)

Dosage form Box of 7 blisters x 4 tablets
Specifications Omeprazole

Ingredient

Composition information	Content
Omeprazole	20mg

Uses

indications

Mepraz® drugs are indicated in the following cases:

Short -term treatment of progressive duodenal ulcer (should not use Mepraz® to treat patients with duodenal ulcer).

Mechanism of action

Mepraz® is a new anti -secreting group, it inhibits the enzyme H+/K+ atpase (proton pump) of the stomach lining cells. The mechanism of action of Mepraz® is different from cholinergic anti -anti -antihistamine drugs. Mepraz® is combined with the H+/K+ ATPASE enzyme system and inhibits the final stage of the acid process. This effect leads to inhibition of basic acid secretion and acid secretion due to stimulation, any origin.

Antibiotics

After taking the drug, the anti -secreting effect of Mepraz® occurs within 1 hour, reaching the maximum after 2 hours. After 24 hours, the inhibition of acid secretion remains at 50% compared to the maximum level and the inhibitory time lasts up to 72 hours. This effect is much longer if it comes to the relationship with a very short selling time (less than 1 hour), due to the long combination with the H+/K+ ATPASE enzyme system in the stomach wall.

When stopping the drug, the anti -secretion effect decreases slowly after 3-5 days. Mepraz®'s inhibitory effect on acid secretion increases with the only dose of every day and reaches a constant level after 4 days.

Pharmacokinetics

absorption

Omeprazole is quickly absorbed with peak plasma concentrations reached in the range of 0.5 - 3.5 hours. The peak and AUC concentration is proportional to the dose of up to 40 mg. Absolute bioavailability of about 30-40% at a dose of 20-40 mg due to the majority of drugs that have been metabolized before. In healthy people, the sale time in plasma is about 0.5 - 1 hour, the total clearance of the body is 500 - 600 ml/min.

Distribution

drugs associated with plasma protein about 95%.

Metabolism

Omeprazole is strongly metabolized through the cytochrome p450 enzyme system.

Elimination

About 77% of the dose is eliminated in the urine in the form of metabolites, the rest is excreted through urine in the form of non -metabolic.

Before taking Hard capsules Mepraz 20mg Sanofi treat peptic ulcer, reflux esophagitis (7 blisters x 4 tablets)

How to use

Take oral use.

Should drink meepraz® before eating.

Do not open, chew or crush the pill but should take whole tablets.

Dosage

Short -term treatment for duodenal ulcer: The dose for adults is 20 mg once a day.

Most patients heal scars within 4 weeks. Some may need 4 more weeks of treatment.

Stomach ulcers: 20 mg orally once a day for 4 - 8 weeks.

Esophagitis due to severe corrosion or gastroesophageal reflux disease - poorly responded to treatment: adult dose is 20mg/day for 4-8 weeks.

Pathological increased conditions: The starting dose in adults is 60 mg once daily.

Should adjust the dose depending on the needs of each patient and the treatment time depending on the clinical response.

Can be used up to 120 mg 3 times/day. High doses above 80mg should be divided into smaller doses.

No dose adjustment in patients with renal impairment, liver dysfunction or the elderly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Dosage causes overdose up to 2400 mg (120 times the recommended clinical dose). Manifestations include sensory disorders, drowsiness, blurred vision, fast heartbeat, nausea, vomiting, sweating, blushing, headache, dry mouth ... These symptoms are usually only fleeting, no serious cases have been reported due to overdose Omeprazole.

Handling

There is no specific antidote. Omeprazole is connected to protein, so it cannot be separated. In case of overdose, symptomatic treatment and supportive treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Mepraz 20 mg, you may experience unwanted effects (ADR).

Mepraz® is well tolerated. The side effects may be encountered but rarely: nausea, headache, diarrhea, constipation, flatulence and skin rash.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Mepraz® drug contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Not used for pregnant women.

Be cautious when used

symptomatic response to Mepraz® therapy does not allow elimination of malignant pathology in the stomach.

Should stop breastfeeding in mothers using Mepraz®.

The ability to drive and operate machinery

No report.

Pregnancy

Not for pregnant women.

Breastfeeding period

No report.

Drug interaction

Absorption of some drugs can be affected by a reduced acidity in the stomach: Ketoconazole absorption will be reduced when treated with Mepraz®.

Mepraz® is metabolized in the liver through the enamel system of Cytochrome P450, so the drug can extend the time to eliminate Diazepam, Warfarin and Phenyltoin. However, simultaneous use with Mepraz® does not change the concentration of these drugs in the blood.

The concentrations of meepraz® and clarithromycin both increase when using these two drugs.

drugs do not interact with food or with antacids when used simultaneously with these drugs.

Storage

At temperatures below 30 ° C, avoid direct light and wet place.

Other drugs

Disclaimer

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