Hasitec 5 Hasan Treatment Treatment of Hypertension, Heart failure (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Enalapril

Ingredient

Composition information	Content
Enalapril	5mg

Uses

indications

Hasitec 5 mg drug is indicated in the following cases:

Treatment of hypertension.

Treatment of heart failure (decreased death and complications in patients with symptoms and asymptomatic left ventricular dysplasia patients). Learning

enalapril is an angiotensin transferring enzyme inhibitor (ACE) Angiotensin I into angiotensin II (strong vascular contraction), which works by enalaprilat as an enalapril metabolic substance after taken. Enalapril lowers blood pressure in people with normal blood pressure, hypertension, and has a good effect on hemodynamics in people with congested heart failure, mainly due to inhibition of the Renin - Angiotensin - Aldosteron system.

Enalapril reduces serum aldosteron, leading to a decrease in sodium retention, increasing the Kallikrein - Kinin vasodilation system and can change Prustenoid metabolism and inhibit sympathetic nervous system. Enalapril also inhibits Bradykinin decomposition, a strong vasodilator.

In patients with hypertension, Enalapril reduces blood pressure by reducing the entire peripheral resistance, accompanied by a slight increase or no increase in heart frequency, centrifugal flow or cardiac flow.

Aortic dilatation and may also be veins. Enalapril often reduces systolic and diastolic blood pressure by about 10-15% in both lying and sitting positions. Hypoglycemia and tachycardia rarely occur, but often seen in humans hypoglycemia or decreased volume.

In patients with congestion heart failure, Enalapril often combines with heart glycosides and diuretics, reduces the entire peripheral resistance, stiff pulmonary artery pressure, heart size, average artery pressure and right atrial pressure. Heart index, cardiac supply, systolic volume and increased intense tolerance.

Enalapril decreases after the burden. Left ventricular hypertrophy decreases after 2-3 months of using enzyme inhibitors Angiotensin transfer, because angiotensin II is a strong stimulant of myocardial growth.

In patients with diabetes, Enalapril reduces protein-excretion. Enalapril also increases the sensitivity to insulin in patients with hypertension or without diabetes.

Enalapril does not reduce lipid metabolism at any extent.

Pharmacokinetics

absorption

After drinking, about 60% of Enalapril dose is absorbed through the gastrointestinal tract. The peak concentration of the serum is reached within 0.5 - 1.5 hours. Hemorrhagic effect lasts about 24 hours. Food does not affect the absorption of drugs.

Distribution

About 50 - 60% Enalapril is linked to plasma proteins.

Metabolism

After absorption, Enalapril is hydrolyzed in the liver into Enalaprilate. The peak concentration of enalaprilate in serum appears within 3-4 hours.

Elimination

About 60% of oral dose is excreted into urine in the form of enalaprilate and non -metabolic form, the rest is eliminated according to feces. The sale time of the drug is about 11 hours. Hematomotic and peritoneal jurisdom can eliminate enalapril from the circulation.

Before taking Hasitec 5 Hasan Treatment Treatment of Hypertension, Heart failure (3 blisters x 10 tablets)

How to use

Hasitec 5 mg oral drugs.

Dosage

The dosage of the drug must be adjusted depending on the individual.

Adults

Definitely hypertension

Starting dose: 2.5 - 5.0 mg/day.

Maintenance dose: 10 - 20 mg/time/day. Adjust the dose according to the patient's blood pressure response.

Maximum dose: 40 mg/day.

Simultaneous treatment with diuretics: Stop diuretics (if possible) for 1-3 days before starting Enalapril treatment and it is necessary to take the drug at a very low initial dose, 5 mg/day or less. Gradually increase the dose carefully according to the treatment response.

heart failure

In the first week: 2.5 mg/time/day x 3 days; 2.5 mg x 2 times/day x 4 days.

can then increase the dose gradually to the normal maintenance dose 20 mg/day, use once or divide into 2 times, in the morning and evening. In rare cases, a dose may be increased to 40 mg/day. Adjust the dose for 2-4 weeks.

Interpretation of leftless left ventricular function

Starting dose: 2.5 mg x 2 times/day, in the morning and evening. Adjust the dose continuously to the appropriate dose. Can gradually increase the dose up to 20 mg/day, divided into 2 times in the morning and evening.

Kidney disease due to diabetes

Starting dose: 5 mg/time/day.

Maintenance dose: 10 - 40 mg/day, used once or divided into 2 times.

Patients with renal failure

Need to reduce the dose or extend the distance between the dose:

Creatinine clearance (ml/min)

Initial doses (mg/day)

80 - 30

5 - 10

29 - 10

2.5 - 5

2.5

Using 2.5 mg of enalapril on the day of hemorrhage for patients to reduce severe kidney function is treated with hemorrhage. The following days adjust the dose by blood pressure.

Children

The safety and effectiveness of Enalapril in children has not been proven.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Hemodiac can eliminate enalapril from circulation.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hasitec 5 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: headache, dizziness, fatigue, insomnia, paresthesia, sympathy.

digestive: taste disorders, diarrhea, nausea, vomiting, abdominal pain. Cardiovascular: angioedema, severe hypotension, hypotension posture, fainting, brushing chest, chest pain.

DA: rash. Respiratory: dry cough. kidney: renal failure.

Uncommon, 1/1000

Blood: Hemoglobin and hematocrit, granulocytes, neutropenia.

kidney: proteinuria.

Neurological: panic, agitation, severe depression.

Rare, 1/10000

Digestive: intestinal obstruction, increased oral lining.

liver - bile: pancreatitis, hepatitis cholestasis. immunity: hypersensitivity. nerve: depression.

eyes: blurred vision.

Respiratory: stuffy nose, bronchospasm and asthma.

Muscle muscle: muscle pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Hasitec 5 mg contraindicated in the following cases:

Hypersensitivity to Enalapril or any ingredient of the drug.

eagown at the beginning of treatment.

Renal artery stenosis on both sides of the kidneys or kidney stenosis in patients with only one kidney.

Aortic valve stenosis and severe congested heart muscle disease.

Hypotension previously.

Be cautious when used

Patients with reduced renal function should be adjusted dose, especially when treated in combination with other antihypertensive drugs. Within 4 weeks, if treatment results are not achieved, dose increasing or considering other anti -hypertension drugs.

Patients suspected of having renal artery stenosis: blood creatinine quantitative before treatment.

Patients with severe heart failure (degree 4), impaired renal function and/or an irregularity trend of electrolytes: must be carefully monitored at the hospital right from the beginning of treatment. This principle is also applied when combined with vasodilators.

Patients with left -uneensed left ventricular failure: Monitoring blood pressure and tight kidney function before and after starting treatment to avoid severe hypotension and kidney failure. If possible, diuretics should be reduced before starting with enalapril. Should monitor serum potassium concentration and adjust to normal.

There have been cases of severe hypotension after the first enalapril dose and 2-3% of people in clinical trials must stop treatment. Original hypotension is usually not maintained during the treatment.

The ability to drive and operate machinery

enalapril can cause dizziness, dizziness. Therefore, if there are these symptoms, it is necessary to avoid operating trains, machinery or activities that need alertness.

Pregnancy

Enalapril can cause disease and death for the fetus and infants when the pregnant mother uses the drug. Using drugs for 3 months between and the last 3 months of pregnancy can cause disease leading to pregnancy and damage to newborns, including lowering blood pressure, reducing newborn skulls, recovery or non -recovery and death. Must stop using enalapril as soon as possible after detecting pregnancy.

breastfeeding period

enalapril excreted into breast milk. With the usual dose of treatment, the risk of harmful effects for breastfeeding is very low.

Medicinal interaction

Some other vasodilators (such as nitrate) or anesthesia: simultaneous use with enalapril can cause severe hypotension.

Diuretics: Occasionally can cause excessive hypotension after starting treatment with enalapril.

Medications that release renin (such as diuretics): increase the hypotension effect of enalapril.

Serum hyperkalys (such as potassium diuretics, potassium or salt supplements): simultaneously used with enalapril can cause serum hyperpassia, especially in patients with renal impairment, therefore should monitor patients closely and regularly monitor potassium levels.

Lithi: Enalapril may increase blood lithium levels leading to lithium poisoning.

Parurian bronchodilators, nonsteroidal anti -inflammatory drugs (NSAID): may reduce the hypotension effect of Enalapril.

contraceptive drugs: Concomitant use with Enalapril causing increased risk of vascular lesions and difficult to control blood pressure.

Beta - adrenergic blockers, methyldopa, nitrate, calcium, hydralazine, prazosin and digoxin: do not show clinical side effects.

Storage

Dry place, less than 30ºC.

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