Hatrizol 20mg DHG medicine treats gastroesophageal reflux, esophagus (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	20mg

Uses

indications

Hatrizol is indicated in the following cases:

Treatment of gastroesophageal reflux, gastric ulcer - duodenum and Zollinger - Ellison syndrome. Thick.

The effect is fast, prolonged but recovered. Omeprazole does not work on receptors (receptor) acetylcholine or histamine receptors. Maximum effect after taking 4 days.

pharmacokinetics

absorption:

Omeprazole is completely absorbed in the small intestine after drinking 3–6 hours. Bioiology is about 60%.

The drug is highly attached to plasma proteins (about 95%) and is distributed in tissues, especially in the border cells of the stomach.

Omeprazole is completely metabolized in the liver, rapidly eliminated, mainly through urine (80%), the rest according to feces. The metabolites are not active, but interact with many other drugs due to inhibiting the enzymes of Cytochrome P450.

Short waste sale time (about 40 minutes), but the acid excretion inhibitory effect is prolonged, so it can be used only once a day.

The pharmacokinetics of the drug does not make sense in the elderly or the person with renal function. In people with liver function, the bioavailability of the drug increases and the clearance of drugs decreases, but there is no accumulation of drugs and metabolites of the drug in the body.

Before taking Hatrizol 20mg DHG medicine treats gastroesophageal reflux, esophagus (3 blisters x 10 tablets)

How to use

oral medication. Take 30 minutes before breakfast.

Dosage

Treatment of esophagitis due to gastroesophageal reflux - esophagus: The common dose is 20–40 mg (1–2 capsules) x 1 time/day, for 4 to 8 weeks; The treatment can then be maintained at a dose of 20 mg once a day.

Ulcerative treatment: Take 20 mg (1 tablet) x 1 time/day, severe cases can use 40 mg (2 tablets), for 4 weeks if it is duodenal ulcer, for 8 weeks if it is a stomach ulcer.

Treatment of Zollinger - Ellison syndrome: Take 60 mg (3 tablets) x 1 time/day, if the dose is higher than 80 mg (4 tablets), then divide 2 times daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hatrizol, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Headache, drowsiness, dizziness, vomiting, nausea, constipation, bloating.

Uncommon, 1/1000

Insomnia, fatigue, sensory disorders, itching, urticaria, temporarily increased transaminase liver enzymes.

Rare, 1/10000

Sweating, peripheral edema, hypersensitivity including angioedema, fever, anaphylaxis. Bronchospasm in people with liver failure, joint pain, muscle pain, interstitial nephritis ...

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Hatrizol drugs contraindicated in the following cases:

Sensitive to the ingredients of the drug.

Be cautious when using

need to rule out the possibility of malignant tumors before treatment because the drug can cover the symptoms, thus making a late diagnosis.

The ability to drive and operate machinery

The drug can cause unwanted effects such as headache, drowsiness, dizziness, so do not drive and operate machinery during the use of the drug.

Pregnancy

Although experiments do not see omeprazole is likely to cause deformities and toxic to the fetus, but should not be used for pregnant women, especially in the first 3 months.

breastfeeding period

should not use omeprazole in nursing mothers.

Interactive drug

The drug extends the time to eliminate diazepam, phenytoin, warfarin, metabolic drugs through the cytochrome enzyme system P450.

Omeprazole may increase the concentration of cyclosporin in the blood, increasing the effect of dicoumarol and antibiotic eradication H.pylori.

Omeprazole reduces nifedipine metabolism at least 20% and may increase the effect of nifedipine.

Clarithromycin inhibits omeprazole metabolism and makes Omeprazole concentration doubled.

Storage

In a dry place, the temperature does not exceed 30ºC, avoiding light.

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