HAXIUM 40 DHG medicine supports prevention and treatment of stomach - duodenal ulcer (3 blisters x 10 tablets)

Esomeprazol is the isomorphic form of omeprazol and reduces the secretion of stomach acid with a specialized mechanism of action. The drug is a specific inhibitor of acid pump in the wall of the wall. Esomeprazol is a weak alkaline, concentrated and transformed into an active form in a high acidic environment in the sub -control tube of the cell's secretion, at H+K+ATPase inhibitors (acid pump) and inhibits both basic fluid and stimulating fluid.

Dynamic pharmacokinetics

Esomeprazol absorbed quickly after drinking, reaching the highest concentration in plasma after 1-2 hours.

Esomeprazol's bioavailability increases according to the dose and when used to repeat, drifting about 68% when taking the dose of 20mg and 89% when taking the dose of 40mg. Food slows down and reduces Esomeprazol absorption. The area under the curve (AUC) after taking a single dose Esomeprazol 40mg at meals compared to the hunger decreased from 43% to 53%. Therefore, Esomeprazol must drink at least 1 hour before meals.

About 97% Esomeprazol attaches to plasma proteins. The drug is metabolized mainly in the liver thanks to the Cytochrom P450 enzyme system, isenzy CYP2C19, into hydroxy and desmethyl metabolites that are no longer active. The rest is converted through isenzyme CYP3A4 to Esomeprazol Sulfon.

Half lifetime eliminated in plasma 1.3 hours. About 80% of oral doses are eliminated in the form of non -active metabolites in the urine, the rest is eliminated in feces, in severe liver failure, AUC value in a stable state is 2-3 times higher than people with normal liver function. Therefore, it may be necessary to consider reducing the dose of Esomeprazol in these patients.

Note:

with a dose of 20mg and 10mg: suggest switching to using other suitable products. Or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

So far there is very little experience in intentional overdose. The described symptoms related to the use of 280 mg oral dose are gastrointestinal disorders and depression. Esomeprazol single doses of oral 80 mg are still safe to use.

How to handle

There is no specific antidote when overdose of Esomeprazol. Esomeprazol is strongly connected to plasma proteins and therefore not easily separated. In case of overdose, symptomatic treatment and use of general support measures.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Notify the doctor with unwanted effects when using the drug.

Instructions on how to handle ADR

Notify the physician the unwanted effects when using the drug.

Be cautious when using

when there is a warning symptom (such as: unexpected weight loss, recurrent vomiting, difficulty swallowing, vomiting of blood or defecation of black blood), when there is a suspected stomach ulcer, eliminate malignant ability because Esomeprazol treatment can cover symptoms and delay diagnosis.

Patients with long -term treatment (especially patients taking drugs for more than 1 year) need to monitor regularly.

Proton pump inhibitors can lead to a slight increase in the risk of gastrointestinal infections such as Salmonella and Campylobacter.

The effect of the drug on the ability to drive and operate machinery

Caution for those who are operating machinery, driving train, people who are working on high and other cases due to drugs that are likely to cause headaches, dizziness.

Use drugs for women during pregnancy and lactation

The drug does not affect pregnant and lactating women. However, like other drugs, caution should be used when using these drugs.

Drug interaction

Due to acid excretion inhibition, Esomeprazole increases the gastric pH, affecting the bioavailability of pH -dependent absorption drugs: ketoconazol, otraconazole, erlotinib, iron salt, digoxin.

Esomeprazol inhibits CYP2C19, the main enzyme metabolizes Esomeprazol. Therefore, when Esomeprazol is used with metabolic drugs with CYP2C19 such as Diazepam, Citalopram, Imipramirí, Clomipramin, Phenytoin, ... The concentration of these drugs in plasma can increase and need to decrease the dose.

Esomeprazol is metabolized by CYP2C19 and CYP3A4. When using Esomeprazol simultaneously with a CYP3A4 inhibitor, Clarithromycin (500mg, 2 times/ day) double the area under the curve (AUC) of Esomeprazol. Concomitant use of Esomeprazol along with an inhibitor of both CYP2C19 and CYP3A4 may increase the concentration and contact time of Esomeprazol.

Need to adjust the dose in patients with severe hepatic or long -term treatment.