Hayex Davipharm Treatment of bronchial asthma, bronchospasm (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bambuterol

Ingredient

Composition information	Content
Bambuterol	10mg

Uses

Indications

orex is indicated in the following cases:

Treatment of bronchial asthma, bronchospasm and/ or obstruction of the respiratory tract have recovered.

Pharmacokology

bambuterol is the precursor of terbutalin, the owner of the symptom on receptor β, selective stimulation on β2 (especially bronchial, uterus, blood vessels) compared to β1 heart. Due to this selection, the effect of the drug on the heart is mild at the usual doses but can also occur in high doses. Bambuterol is bis-hadethylcarbamat of terbutalin.

Pharmacological studies have been conducted on people with bronchial asthma and healthy people. The effects recorded include bronchiectasis, tremor and heart rate.

pharmacokinetics

absorption:

Average 17.5% of the dose of bambuterol oral oral absorption is absorbed, about 70-90% of the absorption occurs in the first 24 hours. Of which, 50 - 80% of the drug in the circulation is constant, meaning Bambuterol's bioavailability is about 10 - 12%. The absorption of drugs is not affected when used simultaneously with food.

Distribution:

The ratio of bambuterol has low plasma proteins, about 40-50% at treatment concentration.

Bambuterol's active metabolites, terbutalin, can pass the placenta fence and are distributed into breast milk.

Metabolism:

After absorption, bambuterol is metabolized in the liver by hydrolysis reaction (by cholinesterase enzyme in plasma) and oxidized into active terbutalin. After being absorbed from the intestine, about 2/3 of the terbutalin was first metabolized through the liver, Bambuterol was not first metabolized through the liver.

Era:

Bambuterol and its metabolic forms including terbutalin are excreted mainly through the kidneys. Bambuterol's waste sale time after drinking is 9 - 17 hours.

Before taking Hayex Davipharm Treatment of bronchial asthma, bronchospasm (3 blisters x 10 tablets)

How to use

Dose of 1 tablet/ day, should be used immediately before going to bed. Need to adjust the dose appropriately.

Dosage

Adults:

recommended starting dose 10 - 20 mg. The 10 mg dose may increase to 20 mg after 1-2 weeks, depending on the clinical effect. In patients who have previously tolerated the agonized owners β2, the starting dose as well as the recommended maintenance dose is 20 mg.

Elderly (≥ 65 years):

No dose adjustment.

significant liver dysfunction:

There is no recommendation for use because the conversion into terbutalin cannot be predicted.

Average to severe kidney failure (GFR ≤ 50 ml/ minute):

Recommended reduction of the starting dose of Bambuterol is half in these patients.

Children:

Do not recommend use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In case of severe overdose, depending on the case, it is necessary to conduct the following treatments: gastric lavage, activated carbon.

Assess the balance of acid, blood sugar and electrolytes. Monitor the frequency, heart rate and blood pressure. The appropriate detoxification agent when overdose bambuterol is a selective receptor inhibitor β, but receptor inhibitors β should be used cautiously in patients with a history of bronchospasm. If the peripheral resistance is reduced by intermediaries β2, significantly contributes to reducing blood pressure, it is necessary to increase the volume of plasma.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using orex, you may experience unwanted effects (ADR).

Very common, common, ADR> 1/100:

Mental: behavioral disorders (such as: restlessness), sleep disorders.

nerve: Run, headache.

Cardiovascular: Brushing the chest.

muscle - bone - joints: cramps.

Uncommon, 1/1000

Mental: behavioral disorders (such as agitation).

Cardiovascular: tachycardia, arrhythmia such as atrial fibrillation, ventricular tachycardia and extra mind.

Unknown frequency ADR:

Immune: Hypersensitivity, including angioedema, urticaria, rash, bronchospasm, hypotension and fainting.

Metabolism and nutrition: Hypotension, hyperglycemia.

Mental: Dizziness, excessive hyperactivity.

cardiovascular: myocardial ischemia.

Respiratory, chest and mediastinum: paradoxical bronchospasm.

digestive: nausea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hayex drugs in the following cases:

Sensitive to Bambuterol, Terbutalin or any ingredients of the drug.

Children under 15 years of age due to drug data on this group of objects is limited.

Pregnant and lactating women.

Be cautious when using

as well as for all agonized substances β2, cautious use in patients with toxic toxicity.

Cardiovascular effects can be seen when using sympathetic drugs, including bambuterol.

There has been a report of myocardial ischemia related to the agonist β. Patients with severe cardiovascular disease (such as heart disease due to ischemia, coronary artery disease, arrhythmia or severe heart failure, severe or uncontrolled hypertension) need to be warned immediately to contact the doctor if they feel chest pain or symptoms of severe heart disease. It should be noted to assess symptoms such as shortness of breath and chest pain as it can be a sign of respiratory or heart.

Although bambuterol is not indicated for premature labor, it should be noted that Bambuterol is transformed into Terbutalin and Terbutalin should not be used as an anti -uterine spasm in patients with myocardial ischemia or patients at high risk of myocardial ischemia.

Due to the effect of increasing the blood sugar of the agonetic substances β2, it is necessary to enhance blood sugar control when starting treatment in diabetes patients, especially when combined with the body -acting corticosteroids.

Due to the effect of contraction of the β2 owner, these drugs should not be used in patients with myocardial hypertrophy.

The agonist β2 can cause arrhythmia, which must be considered for treatment for each patient.

The transformation between individuals in converting bambuterol into terbutalin cannot be predicted in patients with cirrhosis. It is recommended to use another β2 agonist for cirrhosis patients and other serious liver function impairments.

Hyperbathed hypokarybia may occur when treated with β2 agonized substances. It is necessary to be especially prudent in acute severe severity due to the risk of hypokalemia when hypoxemia. The impact of hypokalemia may increase when combined treatment, serum potassium concentration is needed in these cases.

Patients with bronchial asthma must be used for optimal anti -inflammatory therapy such as inhaled corticosteroids, Leukotrien receptor antagonists. Patients must be instructed to continue using their anti -inflammatory drugs after starting with bambuterol, even if the symptoms of asthma have decreased.

If the previous effective dose is no longer responding, proving that the disease has worsen. Patients should be consulted immediately, and at the same time conduct the effectiveness of bronchial asthma treatment. It is necessary to consider the requirements for additional treatment (including increased anti -inflammatory dose). Treatment with bambuterol must not start or increase the dose during acute bronchial asthma. Severe bronchial asthma should be treated as usual.

Precautions when treating patients prone to glaucom angle.

The ability to drive and operate machinery

The drug does not affect or affect the ability to drive and operate machinery.

Pregnancy

drugs should be contraindicated for pregnant women.

Hypoglycemia is recorded in premature babies whose mothers are treated with the agonetic substance β2.

The period of breastfeeding

It is necessary to consider stopping breastfeeding or stopping the drug based on the evaluation between the benefits of breastfeeding and the benefits of treatment for the mother, contraindicating using bambuterol during breastfeeding.

Drug interaction

Halogen anesthetics: Avoid using Halothan to anesthesia while being treated with β2 agonized substances because it may increase the risk of arrhythmia. Should be cautious when using Halogen anesthesia is different from the agonist β2. In obstetric intervention, it may reduce uterine contractions along with increased risk of bleeding.

substances that reduce potassium and hypokalemia: Reducing blood potassium may occur when treated with β2 agonized substances and severe treatment when treated simultaneously with substances that cause serum potassium loss such as derivatives of xanthin, diuretics and diuretics.

Be cautious when using bambuterol in patients who are taking other sympathetic drugs.

Treatment of diabetes: Glucose increases due to β stimulating effect. Need to strengthen monitoring of blood sugar and urine.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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