Helinzole 20mg SPM treatment for stomach ulcers, duodenum ulcers (3 blisters x 8 tablets)

Dosage form Box of 3 blisters x 8 tablets
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	20mg

Uses

Indications

Helinzole drugs are indicated in the following cases: Treatment of stomach ulcers, duodenum, esophagitis due to reflux, zollinger acid secretion syndrome.

Pharmacokology

Omeprazole belongs to the group of new generation anti -secreting compounds, which prevents stomach acid secretion by inhibiting the enzyme system H+/K+ ATPAS

Omeprazol is described as a gastric acid pump inhibitor, blockade of the final stage of acid production. This effect is related to the dose, resulting in inhibition of both basic acid secretion and acid secretion regardless of any stimulant agent.

Anti -secretive activity: After taking the drug, the anti -secreting effect starts within 1 hour, the maximum efficiency is achieved after 2 hours. The secret inhibition is about 50% after 24 hours and the inhibitor time lasts up to 72 hours. Therefore anti -secreting effects exist longer, although the half -life is short. Omeprazol's acid secretion effect increases after continuous use of the only daily dose, the usual dose is effective after 6 days.

Dynamic pharmacokinetics

absorption: Helinzole contains omeprazol is prepared in the form of micro -soluble granules (because omeprazol is decomposed in acidic environment). The drug is absorbed quickly, the peak in plasma is reached within 0.5 to 3.5 hours. Absolute bioavailability of about 30-40% at the dose of 20 - 40mg is mainly due to system metabolism.

Distribution: Omeprazol is highly attached to plasma proteins (about 95%) and is distributed in tissues, especially in the edges of the stomach.

Metabolic: Semi -cancellation time in plasma is from 0.5 to 1 hour. Completely metabolized in the liver. The metabolites are not active.

Elimination: Most of the dose (about 80%) is eliminated through urine, the rest according to feces.

Before taking Helinzole 20mg SPM treatment for stomach ulcers, duodenum ulcers (3 blisters x 8 tablets)

How to use

use it before breakfast or in the evening, swallow the whole pill, do not stop drinking suddenly.

Dosage

Dosage for patients with stomach ulcers, duodenum, and esophagitis due to reflux

Take 1 tablet (20mg), once a day.

In patients with duodenal ulcer

Take continuously for 2 weeks. If not completely healed, drink another 2 weeks.

In patients with stomach ulcers and esophagitis due to reflux

Take continuously for 4 weeks. If not completely, drink 4 more weeks.

In patients with stomach ulcers, duodenum, esophagitis due to severe reflux and resistance to other drugs

Take 2 capsules 1 time (40mg), drink 1 time. Take continuously for 4 - 8 weeks.

Dosage for patients with gastric acid secretion syndrome (Ellison - Ellison)

Starting dose of 3 omeprazol (60mg), taken 1 time daily.

In patients with serious patients and not fully responding to other drugs

Take the maintenance dose of 1-3 capsules at a time (20mg - 60mg). Drink 1-2 times a day.

In patients with Zollinger-Elison syndrome treatment

If the dose is over 80mg, then divide 2 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Using more drugs will not improve your symptoms, instead they can cause poisoning or serious side effects. If you suspect that you or anyone else may have overdosed Helinzole, please go to the emergency room at the closest hospital or hospital. Carry a box, shell, or a pharmacy with you to help doctors have the necessary information.

Oral dose once to 160mg, an intravenous injection to 80mg, a daily intravenous dose to 200mg and a dose of 520mg intravenously for 3 days is still well tolerated.

When overdose, symptomatic treatment must be treated, there is no specific treatment.

Notice immediately to the doctor the unwanted effects encountered when using an overdose.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Helinzole medicine causes the following side effects:

Common, ADR> 1/100

Body: headache, drowsiness, dizziness.

digestive: nausea, vomiting, abdominal pain, constipation, abdominal distention

Uncommon, 1/1000

Neurological: insomnia, sensory disorders, dizziness, fatigue.

Skin: urticaria, itching, unclear rash, red rash, peeling dermatitis, water balls.

Liver: temporarily increased transaminase.

Rare, ADR

Systemic: sweating, peripheral edema, hypersensitivity including angioedema, fever, anaphylaxis, hair loss, stomatitis.

Hematology: leukopenia, thrombocytopenia, all blood cells, granulocytes, blood sodium lower.

Neurological: Confusion has recovery, agitation, depression, hallucinations in elderly patients and especially in serious patients, hearing disorders, loss of air conditioning.

Endocrine: Helpless in men, big breasts in women.

Gastrointestinal: Gastritis, Candida infection, dry mouth, gastrointestinal infection.

Liver: Hepatitis jaundice or no jaundice, liver enzyme increased, toxicity of toxicity, cerebral disease in people with liver failure.

Eyes: blindness, vision loss, hearing disorders, eye inflammation.

Respiratory: bronchospasm, pneumonia.

muscle - bone: joint pain, muscle pain, gout.

urinary - sex: interstitial nephritis.

Instructions on how to handle ADR: Must stop the drug when there is an unwanted effect.

Notify the doctor about unwanted effects when using the drug.

Warnings

Contraindications

Too sensitive to any ingredients of the drug.

Not for pregnant women in the first 3 months.

Be cautious when taking drugs

When suspected stomach ulcers, want to use omeprazol, must first eliminate the possibility of malignant diseases because treatment can reduce symptoms and hinder diagnosis.

The ability to drive and operate machinery

Do not use omeprazol while operating machinery and trains because the drug can cause dizziness, drowsiness.

Pregnancy and lactation

Pregnancy

Although the experiment does not see omeprazol has the ability to cause deformities and toxic to the fetus, but should not be used for pregnant women, especially in the first 3 months. If necessary to use, you should consult your doctor to consider benefits and risks.

Breastfeeding period

Do not use omeprazol in nursing mothers. So far, no research documents have concluded on this issue. If necessary, should consult a doctor to consider the benefit of the mother and the risk of the child.

Special subjects (elderly, children, allergies)

No report.

Drug interaction

Omeprazol does not have clinically important interactions when used with food, alcohol, amoxcycilin, bacampicillin, caffeine, lidocaine, quinidine or byophylin.

The drug is also not affected by simultaneous use of Maalox or Metoclopramid.

omeprazol may increase the concentration of ciclosporin in the blood.

omeprazol increases the effect of antibiotic eradication H. pylori.

There is no interaction recorded with propranolol or theophylin.

Omeprazol inhibits the metabolic of drugs metabolized by the enzyme system in Cytocrom P450 and can increase the concentration of diazepam , phenytoin and warfarin in the blood. The metabolism of diazepam makes the effect of the drug longer. With a dose of 40mg/day omeprazole inhibits phenytoin metabolism and increases the concentration of phenytoin in the blood, but the dose of omeprazol 20mg/day has much weaker interaction.

omeprazole inhibits the metabolism of warfarin, but has little change of bleeding time.

omeprazol increases Dicoumarol's anticoagulant effect.

omeprazol metabolizes nifedipine at least 20% and may increase the effect of nifedipine.

Clarithromycin inhibits omeprazol metabolism and makes omeprazol levels double.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist. Keep pills out of reach of children and pets.

Expiry date: 36 months from the date of production

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