Hemfibrat medicine 300mg Ha Tay treatment of hypercholesterol blood cholesterol (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Fenofibrate

Ingredient

Composition information	Content
Fenofibrate	300mg

Uses

indications

Hemfibrat drug is indicated in the following cases:

Treatment of blood cholesterol hypertrophy (type IIA) and endogenous hyperligve (type IV) or coordination (type IIB and III) in adults, after applying the appropriate and persistent but ineffective diet (especially after applying diets that blood cholesterol is still high or when there are risks of coordination). Secondary blood lipoprotein if persistent blood lipoprotein abnormalities, even if they have treated the whole disease (blood lipid disorders in diabetes).

Maintain a diet that is always necessary.

Pharmacological

fenofibrat, derivative of fibric acid, is a blood lipid medication. The liver cholesterol biosynthesis inhibits the liver, reducing the plots that cause very low density of lipoprotein VLDL and Lipoprotein, low density of LDL), increasing the production of high density lipoprotein (HDL) and also reducing blood triglycerides. Therefore, significantly improving cholesterol distribution in plasma.

Fenofibrat is used to treat hyperplote energy lipoprotein IIA, type IIB, Type III, Type IIV and Type V along with a very limited diet of lipids. Fenofibrat can reduce 20-25% of total cholesterol and 40 - 50% of blood triglycerides. Fenofibrat treatment needs to be continuous.

pharmacokinetics

fenofibrat is absorbed right in the digestive tract along with food. Absorbing drugs is greatly reduced if taken after fasting overnight. The drug quickly hydrolyses into fenofibric acid that is active; This substance is attached to plasma albumin and can push vitamin K anti -vitamin drugs from the attachment position.

Peak concentration in plasma appears about 5 hours after taking the drug. In people with normal renal function, the sale time in plasma is about 20 hours but this time increases a lot in people with kidney disease and fenofibric acid accumulated significantly in patients with kidney failure daily.

Fenofibric acid eliminates mainly in urine (70% within 24 hours, 88% within 6 days), mainly in the form of glucuronid complex, in addition to fenofibric acid in the form of reducing and its glucuronid complex.

There is no serious thing when stopping fibrat, even after long -term treatment and sudden removal.

Before taking Hemfibrat medicine 300mg Ha Tay treatment of hypercholesterol blood cholesterol (3 blisters x 10 tablets)

How to use

Fenofibrat treatment is necessarily coordinated with a lipid restriction diet. Must take medicine with meals.

Dosage

Adults: Take 1 capsule 300 mg/day, take a meal. Take medicine under the monitoring of a specialist.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hemfibrat, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: digestive disorders, epigastric area, nausea, bloating, mild diarrhea.

Skin: rash, urticaria, no specific ban.

liver: increased serum transaminase. muscle: muscle aches.

Rare, 1/10000

Liver: bile stones.

genitals: loss of sexuality and impotence, reduced sperm. blood: leukopenia.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Hemfibrat drugs contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Severe kidney failure.

Severe liver dysfunction.

Children under 10 years old.

Pregnant and lactating women.

Be cautious when using

necessarily explore the patient's liver and kidney function before starting to use fibrat.

In patients with anticoagulant drugs: When starting to use fibrat, it is necessary to reduce the anticoagulant dose to only 1/3 of the old dose and adjust if necessary. Need to monitor more frequent amount of blood prothrombin. Adjust the anticoagulant dose during use and after stopping Fibrat 8 days.

Armor weakness can be a factor that increases the likelihood of side effects in muscle.

Need to measure transaminase every 3 months, in the first 12 months of taking the drug.

Must suspend the drug if sgpt (ALT)> 100 international units.

Do not combine fenofibrat with drugs that have a toxic effect with the liver.

Complications are prone to occurrence in patients with hepatomal stasis or gallstones.

If after a few months of taking the drug (3-6 months) and the amount of lipid in the blood changes is not significant, it is necessary to consider other therapy (supplemented or replaced other drugs).

Do not use 300 mg tablets for children, only tablets with this content for patients need a dose of 300 mg fenofibrat/day.

The ability to drive and operate machinery

No report.

Pregnancy

Not for pregnant women.

breastfeeding period

Not used for breastfeeding women.

Drug interaction

Use a combination of HMG - Coa Reductase inhibitors (Pravastatin, Simvastatin, Fluvastatin) and Fibrat will significantly increase the risk of muscle damage and acute pancreatitis.

Combining fibrat with cyclosporin increases the risk of muscle damage.

Fenofibrat increases the effects of anticoagulant oral medications and thus increases the risk of bleeding due to pushing these drugs out of the position attached to plasma proteins. Need to monitor prothrombin more often and adjust the anticoagulant dose during fenofibrat treatment and after 8 -day stop stop.

Do not use the combination of liver poison (Mao inhibitors, Perhexilin Maleat ...) with fenofibrat.

Storage

In a dry place, temperatures below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.