HEPGENTEX 10G RESANDIS skin treatments for dermatitis, skin allergies

Dosage form Tube
Specifications Clotrimazol, Gentamicin, Betamethasone

Ingredient

Composition informationContent
Clotrimazol100mg
Gentamicin10000iu
Betamethasone5mg

Uses

Indications

Hepgentx is indicated in the following cases:

  • Dermatitis and skin allergies: Acute and chronic eczema, atopic dermatitis, contact dermatitis, seborrheic dermatitis, flaking dermatitis, urticaria, chronic flat mites, psoriasis, itching (anus, vulva). Eczema. It has anti -inflammatory, anti -rheumatic and anti -allergic effects.

    Clotrimazol is a broad -spectrum antivirus drug used to treat skin diseases caused by infected fungal species and also work on trichomonas, staphylococus and bacteroides. The mechanism of acting of clotrimazol is linked to phospholipids in the fungal cell membrane, changing the permeability of the membrane, causing loss of intracellular essential substances that lead to the destruction of fungal cells.

    Gentamicin Sulfate is an antibiotic of the aminoglycosides that kill bactericidal effects due to inhibiting bacterial protein biosynthesis. The actual gentamicin antibacterial spectrum includes Gram -negative aerobic bacteria and staphylococcus a staph, including strains that produce penicillinase and methicillin resistance.

    pharmacokinetic

    absorption

    Betamethason is easy to be absorbed when used on the spot, especially when closed or torn wound.

    Clotrimazol used on the skin is very few absorbed. Six hours after applying 1%Clotrimazol cream, Clotrimazol concentration varies from 100µg/cm3 in the horn layer to 0.5 - 1µg/cm3 in the spine layer and 0.1µg/cm3 in the subcutaneous tissue layer.

    Gentamicin is not absorbed through the gastrointestinal tract, diffuses mainly into extracellular fluids.

    Distribution

    When entering the Betamethason body is quickly distributed in tissues.

    Metabolism

    betamethasone metabolizes mainly in the liver and the kidneys.

    Gentamicin is not metabolized.

    Elimination

    betamethason Export in urine.

    Gentamicin is almost unchanged into the filtered urine in the glomerular filter. However, only 70% of the gentamicin is exported in the urine, the rest is accumulated to some extent in the body's tissue, especially in the kidney.

    • Before taking HEPGENTEX 10G RESANDIS skin treatments for dermatitis, skin allergies

    How to use

    Usually apply a small amount of Hepgentex skin cream to the skin area 1-2 times a day.

    Treatment time depends on the degree of disease, the location of the skin area, and the response of each patient.

    Dosage

    Apply 1-2 times a day.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when using overdose?

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Hepgentex, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Metabolism: loss of potassium, sodium holding, water retention, Cushing syndrome development, reduced glucose tolerance, revealing hidden diabetes, increasing insulin demand or hypoglycemic drugs in people with diabetes.
  • Reproduction and breast: Menstrual periods are erratic, inhibit the growth of pregnancy in the uterus and children.
  • muscle system: muscle weakness, loss of muscle mass, osteoporosis.

    • Skin and subcutaneous tissue: Skin atrophy and subcutaneous, sterile abscess, local reactions (> 1%) include mild burns, irritation, dermatitis caused by contact, burning pain.

  • Inner ear and inner ear: non -recovery ear poisoning and due to the accumulation of the earlobe (deafness, initial sound with high frequency sound).
  • Nervous system: The vestibular system (dizziness, dizziness).

    • Uncommon, 1/1000

  • Mental system: refreshment, mood change, severe depression, insomnia.
  • Eye: Glaucoma, opaque glass.

    • Digestive system: stomach ulcers and may then puncture and bleed, pancreatitis, abdominal distention, esophageal ulcer. kidney: Kidney toxicity has recovery, acute renal failure, usually mild but there are also cases of kidney necrosis or interstitial nephritis.

    musculoskeletal joints: Inhibiting neurotransmitter, in some cases of respiratory failure and muscle paralysis.

    Rare ADR

  • Skin: Allergic dermatitis, urticaria.
  • Nervous system: Vascular nervous edema, hyperplanded intracranial pressure.

    • The immune system: Anaphylaxis or hypersensitivity. Biliary liver system: liver dysfunction (hyper enzyme, hyperlirubin blood).

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Hepgentex drugs contraindicated in the following cases:

  • Skin ulcers, burns from level 2 or more, disease.

    • da da, herpes simplex, herpes zoster, chickenpox, syphilis.

  • eczema dermatitis in the outer ear canal with a perforation of the eardrum.

    • History of hypersensitivity to aminoglycosides antibiotics (streptomycin, kanamycin, gentamycin, neomycin ...), bacitracin or any ingredients of preparations.

  • Babies, emulsion.

    • Precautions when used

    The lowest -dose of corticosteroid dose must be used to control the disease. When using corticosteroids must be cautious in case of congestive heart failure, new myocardial infarction, hypertension, diabetes, epilepsy, glaucoma, thyroid defect, liver failure, osteoporosis, stomach ulcers, mental disorders and kidney failure.

    Children can easily increase the risk of some unwanted effects, in addition corticosteroids can cause growth slowly; Elderly people also increase the risk of unwanted effects.

    usually contraindicated corticosteroids in the event of an untreated bacterial infection with appropriate antibacterial chemotherapy. Patients with tuberculosis progress or suspected tuberculosis must not use corticosteroids, except for the case of supplementing treatment for anti -tuberculosis drugs.

    The risk of chickenpox, and maybe even the severe, increased herpes infection in patients is not able to respond to the immune response when using corticosteroids. Using prolonged corticosteroids can cause opaque glass (especially in children), glaucoma with the ability to damage the optic nerve.

    Do not use clotrimazol for the treatment of systemic fungal infections. If irritated or sensitive when using clotrimazol, medication must be stopped and treated appropriately. Must treat the drug enough time despite the symptoms of relief.

    After 4 weeks of treatment, if not supported again. Inform the physician if there is a sign of increased irritation in the topical area (red, itching, burns, blisters, swelling), signs of hypersensitivity.

    All aminoglycosides are toxic to the hearing and kidney. Unexpected effects often occur with elderly patients and/or with patients with renal failure.

    Must be used very carefully if required in people with severe myasthenia gravis, Parkinson or muscle weakness. The risk of kidney toxicity is seen in people with hypotension, or having liver or women.

    Do not apply thick layer, on a large area, in a tight, icy, eyelid, breast area in nursing women.

    The ability to drive and operate machinery

    No report.

    Pregnancy

    Pregnant women use according to the instructions of the physician.

    Should consult a doctor or pharmacist before taking any drug.

    Breastfeeding period

    Should consult a doctor or pharmacist before taking any drug.

    Drug interaction

    No report.

    Storage

    The cool dry place, the temperature does not exceed 30 ° C.

    Other drugs

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