Herpacy 3.5g Samil ointment treats the herpes simplex virus

Dosage form Tube x 3.5g
Specifications Acyclovir

Ingredient

Composition information	Content
Acyclovir	3%

Uses

indications

Herpacy Samil 3.5 g is indicated in the following cases:

Treatment of HERPES SIMPLEX viruses. Acyclovir is phosphoryl turned into active compounds, Acyclovir Triphosphate after going into the herpes -infected cell. The first step in this process needs the presence of thymidine kinase encoded by Herpes Simplex (HSV). Acyclovir Triphosphate acts as an inhibitor and substrate for the specific herpes polymerase DNA, preventing the synthesis of the virus DNA continued without affecting the normal processes of the cell.

Dynamic pharmacokinetics

Acyclovir is quickly absorbed from eye ointment through corneal epithelium and shallow eye tissue, achieving anti -virus concentrations in aquatic fluid. By existing methods that cannot be detected in the blood after applying the eye. However, the amount of traces can be detected in urine. These concentrations are not meaningful in terms of treatment.

Before taking Herpacy 3.5g Samil ointment treats the herpes simplex virus

How to use

Herpacy Samil 3.5 g is applied to the eye. Apply 1 cm of ointment to the lower conjunctiva bag.

Dosage

The common dose is a strip of 1 cm of ointment, 5 times/day about 4 hours apart. Apply 1 cm of ointment to the lower conjunctiva bag. Should continue treatment for at least 3 days after completely healed.

Dosage may vary depending on the patient's symptoms.

used in pediatrics

Safety in children has not been determined.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

However, the overdose of the oral Acyclovir overdose for a few days has led to the effects of the digestive tract (nausea and vomiting) and neurological effects (headache and confusion). Acyclovir can be separated by the blood part.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using the 3.5 g Herpacy Samil, you may experience unwanted effects (ADR).

Smore pain may occur after applying the drug.

Because the shallow corneal disease may occur, full monitoring. If this symptom occurs, the lowest dose should be used and taken appropriate measures.

Occasionally, keratitis (acne keratitis and allergic keratitis), corneal ulcer, conjunctiva scratches, eyelash infections, slightly throbbing pain, ... may occur. If these symptoms appear, the medication should be stopped.

Hypersensitivity: Exposure dermatitis may occur. If this symptom appears, the medication must be stopped and taken appropriate measures.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Herpacy Samil 3.5 g is contraindicated in the following cases:

Patients who know hypersensitivity to acyclovir or any component of excipients.

Caution when using

Caution

If you do not observe the signs of reducing symptoms at 7 days after starting this medication or if the symptoms worsen, you should consider using replacement therapy.

Need to warn the onset of side effects before completion of use. Should avoid this medication as long as possible.

Should avoid carrying soft contact lenses during treatment.

Be cautious when using

Only for eye examination.

When applying this drug in the eyes, be careful to avoid the tip of the drug in direct contact with the eye.

This drug should only be used by a person to prevent drug contamination.

After opening the tube, this drug should be used within 1 month.

Precautions for storage

to be out of reach of children.

Store in a cool dry place to avoid direct sunlight, with a covered lid.

Do not store in other packaging to maintain the quality of the drug and avoid the wrong use.

The ability to drive and operate machinery

eye ointment can affect the ability to see, so be careful when driving or using machinery.

Pregnancy

When used in the first 3 months and the middle 3 months of pregnancy, this drug does not cause teratogenic or toxicity to the workpiece. However, the safety of prolonged use for herpes recurres in the last 3 months of pregnancy has not been determined.

The period of breastfeeding

When taking 200 mg of oral medication 5 times/day, the concentration of drugs in breast milk may be between 0.6 to 4.1 times compared to the corresponding plasma concentration. In this case, the content of the drug in breast milk is 0.3 mg/kg/day. Although it is much less than the recommended dose of 30 mg/kg/day for newborns with herpes, nursing mothers should be warned.

Medicinal interaction

Simultaneous use of zidovudin and acyclovir can cause a state of sleep and drowsiness.

Probenecid inhibits competition to eliminate acyclovir through the renal tubules, so it increases by 40% and reduces excretion through urine and clearance of acyclovir.

Amphotericin B and Ketoconazole increase acyclovir anti -virus effect.

Interferon increases the anti -virus effect of Acyclovir. Be cautious when using acyclovir injection for patients who had previously had a neurological reaction to Interferon.

Using acyclovir should be cautious with patients who have a neurological reaction when using methotrexate.

Storage

Store less than 30 ° C in the original packaging.

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