Hiskedan 20mg Khanh Hoa medicine for stable angina symptoms is not fully controlled (2 blisters x 20 tablets)

Dosage form Box of 2 blisters x 20 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	20mg

Uses

indications

HISmedan drugs are indicated in the following cases:

Used for adults in supplementary therapy/support for existing therapy to treat symptoms in patients with stable angina without adequate control or non-tolerant patients with other angina therapy. 3-ketoacyl-coa thiolase in ischemic cells, energy obtained during oxidation of glucose needs to consume less oxygen than oxidation beta. The promotion of glucose oxidation will help optimize cell energy processing, thus maintaining appropriate energy metabolism during anemia.

Pharmacokinetics

absorption

The drug is quickly absorbed and reaches the peak concentration in plasma before 2 hours after drinking. The maximum concentration of the drug in plasma after taking 20 mg of trimetazidine is about 55 ng/ml.

Distribution

The integral distribution of 4.8 l/kg shows that the diffusion level of the drug is good to the tissues. Trimetazidine associated with low salary protein, the measured value in vitro is 18%.

Elimination

Trimetazidine is mainly excreted in urine in the form of unprocessed. Trimetazidine waste sale time is 6 hours.

Before taking Hiskedan 20mg Khanh Hoa medicine for stable angina symptoms is not fully controlled (2 blisters x 20 tablets)

How to use

oral medication.

Dosage

Usual doses for adults:

1 tablet/time x 3 times/day, use with meals.

Patients with average renal insufficiency (Creatinine clearance 30 - 60 ml/minute):

recommended dose is 1 capsule 2 times/day, morning and evening, with meals.

Elderly patients (may have a higher level of trimetazidine sensitivity than normal due to age impairment):

For patients with average renal impairment, the recommended dose is 1 capsule 2 times/day, morning and evening, with meals. Be careful when calculating the dose for elderly patients.

Children:

The safety and effectiveness of trimetazidine for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hismedan, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: dizziness, headache.

stomach - intestines: abdominal pain, diarrhea, indigestion, nausea and vomiting. skin: rash, itching, urticaria.

weakness.

Rare, 1/10000

Heart: Brushing chest drum, suspense, extra mind, fast heartbeat.

Pentecology: Aortic hypotension, vertical hypotension, can lead to discomfort, dizziness or falling, especially in patients being treated with anti -hypertension drugs, flushing.

Not determined frequency

Neurological: Parkinson's symptoms (Run, slow and difficult movement, muscle tone), unstable gait, vacuum syndrome, other relevant movement disorders, can often be admired after stopping the drug, sleep disorders (insomnia, drowsiness).

stomach - intestines: constipation.

Skin: Outside, acne acne (AGEP), Evaluation. blood: granulocytosis, thrombocytopenia, thrombocytopenic banner.

Hepatitis: Hepatitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

anti -contraindications in the following cases:

Too hypersensitivity to the active ingredient or any excipient is listed in the formula of product preparation.

Parkinson patient, Parkinson's symptoms, tremor, vacuum syndrome and other relevant movement disorders.

Severe renal failure (Creatinine clearance

Be cautious when using

When used for pregnant or lactating women, should consider effectiveness and consequences.

Trimetazidine can cause or worsen Parkinson's symptoms (Run, slow and difficult exercise, increase muscle tone), so patients, especially elderly patients, need regular checks and monitoring. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as Parkinson's symptoms, irritability, tremor, unsteady gaits immediately stop using trimetazidine.

These cases are rarely occurring and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to occur over 4 months after stopping the drug, consulting neurologists.

may have a self, unstable gait or hypotension, especially in patients who are taking medications for hypertension.

Be careful when prescribing trimetazidine for patients with sensitive levels such as patients with average renal impairment, patients over 75 years old.

The ability to drive and operate machinery

trimetazidine can cause dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

does not have enough clinical evidence to eliminate the risk of fetal defects. It is best not to use trimetazidine during pregnancy.

Breastfeeding period

There is not enough evidence of the presence of trimetazidine in breast milk, so the best choice is not to breastfeed during medication.

Interactive drug

There has been no interaction with any drug. Trimetazidine is not an induction drug nor is not a drug that inhibits the enzyme metabolic of the liver. Thus is more likely to trimetazidine does not interact with many metabolic drugs in the liver.

Be careful to monitor when coordinating with another drug.

Storage

less than 30 ° C. Cool dry place, avoid light.

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