HistuDon Hataphar treats dizziness and stroke due to anemia (60ml)

Dosage form Box x 1ml
Specifications Piracetam

Ingredient

Composition information	Content
Piracetam	200mg/ml

Uses

Indications

Histudon drugs are indicated in the following cases:

Treatment of dizziness. In the elderly: memory loss, dizziness, poor concentration, or lack of alertness, mood changes, behavioral disorders, poor attention to themselves, dementia due to cerebral infarction. Attention should be paid to the age and severity of the stroke at first, the most important factors for the ability to survive after -acute anemia stroke. In children treating hard to read. The specific effects as well as its mechanism of action. Even the definition of Hung Tri Nootropic is still vague. In general, the main effect of drugs called Hung Tri (such as: Piracetam, Oxiracetam, Aniracetam, Etiracetam, Pramiracetam, Tenilsetam, Suloctidil, Tamitinol) is improving learning and memory. Many of these are considered to be stronger than Piracetam in terms of learning and memory. It is thought that in normal people and in people with impaired function, Piracetam has a direct effect on the brain to increase the activity of the brain area (the brain area is involved in the mechanism of awareness, learning, memory, alertness and consciousness).

Piracetam acts on some neurotransmitters such as acetylcholin, noradrenalin, dopamin ... This can explain the positive effect of the drug on learning and improve the ability to perform memory tests. The drug can change neurotransmitter and contribute to improving the metabolic environment so that the neurons work well.

Experimental, Piracetam has a protective effect against metabolic disorders due to ischemia by increasing brain resistance to oxygen deficiency. Piracetam increases the mobilization and use of glucose without depending on the supply of oxygen, facilitates the pentose path and maintains energy synthesis in the brain. Piracetam enhances the recovery rate after damage due to lack of oxygen by increasing the rotation of inorganic phosphate and reduces the accumulation of glucose and lactic acid. Under normal conditions as well as without oxygen, Piracetam is found to increase the amount of ATP in the brain due to increased ADP conversion to ATP; This may be a mechanism to explain some useful effects of the drug.

The impact on acetylcholin transmission (increasing the release of acetylcholin) may also contribute to the mechanism of action of the drug. The drug also works to increase the release of dopamine and this may have a good effect on the formation of memory. The drug has no effect on sleep, sedation, resuscitation, pain relief, neurolithic or nervous vase, as well as no effect of GABA.

Pircetamine reduces the ability to converge platelet and in case of abnormal erythrocytes, the drug can cause red blood cells to restore deformation and ability to pass through capillaries. The drug has anti -vibration effect.

pharmacokinetic

absorption

Piracetam used by oral is absorbed quickly and almost entirely in the gastrointestinal tract. Biology nearly 100%. Peak concentration in plasma (40 - 60 micrograms/ml) appears 30 minutes after taking a dose of 2 g. The peak concentration in the cerebrospinal fluid is achieved after taking the drug 2 - 8 hours. Absorbing the drug does not change when long -term treatment.

Distribution

The integral allocation is about 0.6 liters/kg. Piracetam absorbed into all tissues and can be through the blood - brain, placenta barrier and even the membranes used in the renal roses. The drug has high concentrations in the cerebral cortex, forehead lobes, lobes and occipital lobes, cerebellum and base kernel. Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact.

Metabolism and elimination

The kidney's piracetam clearance coefficient in normal people is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine.

Half life in plasma is 4-5 hours. Half life in cerebrospinal fluid is about 6 - 8 hours.

If kidney failure, half -lifetime elimination increases. In patients with absolutely no recovery kidney failure, this time is 48 - 50 hours.

Before taking HistuDon Hataphar treats dizziness and stroke due to anemia (60ml)

How to use

Histudon drugs are taken orally.

Dosage

The usual dose is 30 - 160 mg/kg/day, depending on the indications, divided evenly twice a day or 3-4 times. In severe cases, the dose can be increased to 12 g/day.

Long -term treatment of physical mental syndrome in the elderly: 1.2 - 2.4 g/day, depending on the case. The dose can be high to 4.8 g/day in the first weeks.

An alcoholic treatment: 12 g/ day during the first time of alcohol. Maintenance treatment: Take 2.4 g/day.

Cognitive decline after brain injury (accompanied by dizziness or no): Initial dose is 9 - 12 g/day. The maintenance dose is 2.4 g of medicine, taken at least for at least 3 weeks.

sickle blood cell anemia: 160 mg/kg/day, divided equally into 4 times.

Treatment of muscle vibration: Piracetam is used at a dose of 7.2 g/day, divided into 2-3 times. Depending on the response, every 3-4 days, an increase of 4.8 g per day to a maximum dose of 20 g/day. After reaching the optimal dose of Piracetam, it is advisable to find a way to reduce the dose of the attached drugs.

The drug is only used by a doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is no need for special measures when missing overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Histudon, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: fatigue

Body: Dizziness.

Can reduce the side effects of the drug by reducing the dose.

Notify the doctor with unwanted effects when using the drug.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

anti -contraindications in the following cases:

Hypersensitivity to any component of the drug.

Caution when used

piracetam is discharged through the kidneys, so the half -life of the drug increases directly to the degree of renal failure and creatinine clearance. It is necessary to be very cautious when taking the drug for people with renal failure. Need to monitor kidney function in these patients and elderly patients.

When the clearing coefficient of creatinine is below 60 ml/minute or when the serum creatinine is over 1.25 mg/100ml, the dose adjustments need to be adjusted:

Creatinine clearance coefficient is 60 - 40 ml/min, serum creatinine is 1.25 - 1.7 mg/100 ml (half -life of piracetam is twice as long): only normal dose should be used. hours): Use a normal dose.

The ability to drive and operate machinery

Precautions when using drugs for people who are driving and operating machinery.

Pregnancy

should not use drugs for pregnant women, because the drug may be through the placenta.

breastfeeding period

should not be used for breastfeeding mothers.

Medicinal interaction

can still continue the classic method of alcoholic (vitamins and sedatives) in the case of a person with vitamin deficiency or strong agitation.

There has been a case of interaction between piracetam and thyroid essence when used simultaneously: confusion, stimulation and sleep disorders.

In a patient, prothrombin time has been stabilized by warfarin when using piracetam.

Storage

Where dry, temperatures are below 30 ° C.

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