Hueso Tab 300mg Arlico Treatment of cholesterol gallbladder stones, chronic liver disease (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Ursodeoxycholic Acid

Ingredient

Composition information	Content
Ursodeoxycholic Acid	300mg

Uses

Indications

Hueso tab drugs are indicated in the following cases:

Cholesterol gallbladder stones: Small or asymptomatic gallbladder stones, no contrast, with a diameter of less than 15 mm, the gallbladder is still active, confirmed by cholecystic x -rays), patients with stones but are contraindicated for surgery.

chronic liver disease: Especially they are raw bile cirrhosis, bile fibrosis, liver disease is caused by viscous mucus.

Liver disorders combined with cystic fibrosis in children from 6 to 18 years old.

Pharmacy

Pharmacological group: Ursodexolic acid gastrointestinal group is a secondary bile acid produced from intestinal bacteria, while primary bile acids produced from the liver and accumulated in the gallbladder. When excreted into the colon, primary bile acids can be converted into secondary bile acids by intestinal bacteria strains. Primary and secondary bile acids help the body digest lipids.

Ursodeoxycholic acid has a adjustment activity between the components of bile (reducing cholesterol synthesis in bile), stimulating and helping to regenerate liver cells, creating favorable conditions to dissolve cholesterol stones.

pharmacokinetic pharmacokinetics

absorption and distribution

Ursodeoxycholic acid into the bloodstream and is transferred directly to the liver, spending a small amount of circulation during the circulation.

Metabolism

Ursodeoxycholic acid quickly absorbed into the liver and binded to glycin or taurin and then discharged into the bile. The first metabolism is from 50 to 60%. A small percentage of Ursodeoxycholic acid is subject to metabolism in the liver - intestinal cycle.

Elimination

Ursodeoxycholic acid is eliminated through breast milk, kidneys, bile and mainly through stool.

Before taking Hueso Tab 300mg Arlico Treatment of cholesterol gallbladder stones, chronic liver disease (3 blisters x 10 tablets)

How to use

recommend drinking once in the evening or divided into two mornings and evening.

Dosage

In the treatment of cholesterol gallbladder stones:

The dose works from 5 - 10 mg/kg/day, the average recommended dose is 7.5 mg/kg/day in people with average status.

For obese people, the recommended dose is 10 mg/kg/day, depending on the weight, the dose is from 2-3 tablets/day.

Dosage for children is determined separately based on body mass.

The normal treatment time is 6 months, but if the stones are larger than 1cm, the treatment time may last up to 1 year.

In the treatment of chronic liver disease:

Dosage of treatment from 10 - 15 mg/kg/day. Should start at a dose of 200 mg/day, then increase the dose by steps to achieve optimal treatment at about 4 - 8 weeks of treatment.

Dosage for children is determined separately based on body mass.

In the case of liver disease, it is caused by viscous mucus, the optimal treatment dose is 20mg/kg/day.

How to use: Divide 2 times, drink in the morning and evening, drink with meals.

Liver disorders combined with cystic fibrosis in children from 6 to 18 years old:

20 mg kg/day, divided into 2-3 times, a maximum dose of 30 mg/kg/day

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In addition, there are no other symptoms caused by ursodeoxycholic acid reduced absorption when the dose increases and eliminated through feces. When an overdose occurs, it is necessary to treat symptoms of diarrhea and water - electrolyte balance for patients.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hueso Tab, you may experience unwanted effects (ADR).

Due to poor intestinal solubility, ursodeoxycholic acid does not cause irritation of the mucous membrane, so the cases of diarrhea are very rare.

Increased itching, urticaria at the beginning of severe biliary stasis treatment. Therefore, the recommended starting dose of these patients is 200 mg/day.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hueso tab in the following cases:

Hypersensitivity to the drug.

Patients with complete bile duct congestion (bile benefit effects can worsen symptoms).

Patients with hepatitis progresses rapidly.

Patients with calcium stones.

Patients with acute gallbladder inflammation.

Women who have or suspect pregnancy.

Children under 6 years old.

Patients with kidney disease.

Patients with acute stomach - duodenal ulcer.

Patients with colitis or inflammation like Crohn's disease.

Caution when using

Warning: For long -term treatment therapy, although Ursodeoxycholic acid does not have cancer -causing effects, the rectal monitor is recommended.

In the first 3 months of treatment, it is necessary to monitor the liver enzymes AST (SGOT), ALT (SGPT) and Y-AG 4 times | week. In addition to allowing the determination of response and non -response in patients being treated with biliary cirrhosis, this monitor also helps early detection of liver failure potentials, especially in advanced patients.

Precautions used: In the case of treatment of cholesterol gallbladder stones, it is recommended to check the effectiveness of visual diagnosis after 6 months.

In the treatment of chronic liver disease:

Patients with cirrhosis combined with impaired hepatic or bile cell function (blood bilirubin content on 200 micromol/l), liver function (and, if possible, plasma concentration of bile acids) must be monitored.

In the case of cholestasis causing rashes, the dose of ursodeoxycholic acid should be gradually increased at the starting dose of 200 mg/day. In this case, simultaneous use of cholestyramin is necessary with Cholestyramin conditions that must be used for 5 hours with ursodeoxycholic acid.

Patients with lactase deficiency, lactose intolerance, glucose-galactose absorption should not be taken.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Animal studies have shown the ability to cause teratogenicity. There is not enough research data to assess the likelihood of monitoring or fetal toxicity of this drug when used during pregnancy.

Do not use ursodeoxycholic acid during pregnancy.

Breastfeeding period

Do not know if CID Ursodeoxycholic will go into breast milk or not. Therefore, do not take medicine during breastfeeding. If required to be treated with ursodeoxycholic acid, breastfeeding must be stopped.

Drug interaction

Unsuitable with cholestyramin: The effect of ursodexolic acid is reduced by cohesion with cholestyramine and excreted. If you need to use cholestyramin, it is recommended to use for 5 hours with the time to use ursodeoxycholic acid.

Do not use with estrogen stimulants, as these drugs cause bile cholesterol.

Avoid use with other bile acids such as antacids, activated carbon because it can reduce the effectiveness of treatment.

In some special cases, ursodeoxycholic acid may reduce Ciprofloxacin absorption.

Ursodeoxycholic acid has been shown to reduce the peak concentration in plasma (C Max) and the area under the curve (AUC) of nitrendipine antagonistic nitrendipine. There are also interactive reports that reduce the effectiveness of DASSON treatment.

contraceptives, estrogen hormones and blood cholesterol like clofibrate can increase gallstones.

Storage

Storage in closed packaging, dry and cool place, at temperatures below 30 ° C.

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