Humalog Mix 75/25 Kwixpen injection pen treat diabetes (5 trees x 3ml)

Dosage form Box of 5 trees x 3ml
Specifications Insulin lispro

Ingredient

Thành phần cho 3ml

Composition information	Content
Insulin lispro	300U

Uses

Indications

Humalog Mix 75/25 drugs are indicated in the following cases:

Treatment of patients with diabetes need insulin to maintain normal glucose home stability. Insulin people intermediate effects).

The main activity of insulin lispro is to regulate glucose metabolism.

In addition, insulin has a number of assimilation and anti -catabolic effects on many different types of tissue. In muscle tissue, this effect includes increased glycogen, fatty acids, glycerol, protein and absorbing amino acids, while reducing glycogen resolution, new glucose, formor, grease solving, protein catabolism and amino acid production.

Insulin lispro has a quick act (about 15 minutes), so the patient can take the drug close to the meal (within 0 - 15 minutes when eating meals) compared to normal insulin (before 30 - 45 minutes). Observed the rapid and early peak of Insulin Lisplo after subcutaneous injection Humalog Mix 75/25. Humalog Basal (Insulin Lisplo Protamin mixture) has the same data data with the background insulin (NPH) for about 15 hours.

Clinical trials in patients with type 1 and type 2 diabetes have shown to reduce the level of blood glucose after eating of Humalog Mix 75/25 so insulin people mixed with a mixture of 30/70. In a clinical study, there is a slight increase in blood glucose levels (0.38 mmol/l) at night (at 3 am).

Liver or kidney failure does not affect the dynamic response of glucose with insulin lispro. The dynamic difference of glucose between insulin lispro and insolinated human insulin, as measured in the clamping procedure, holds glucose concentration, is maintained through many levels of kidney function.

The molarity of the lislro insulin is equivalent to human insulin but the insulin lispro is faster and shorter time.

In two open -labeled diagonal studies for 8 months, patients with type 2 diabetes have never used insulin or have been used one or two insulin injections, 4 months treated with Humalog Mix 75/25 (use 2 times/day with metformin) and insulin glargin (1 time/day with Metformin) according to the random sequence. Details are presented in the following table:

n = 78

Patients who used insulin

n = 97

(initial average value = 8.7%)

1.00%

(Average value at the beginning = 8.5%)

The rate of blood glucose at the end of treatment 25% 25% At the end of treatment with Humalog Mix 75/25.

(2) In patients who are randomly used in 75/25 Humalog pen in the first cross.

Dynamic pharmacokinetics

The pharmacokinetics of Insulin Lispro shows that this compound is absorbed quickly and reaches blood peak concentration after 30-70 minutes of subcutaneous injection. The pharmacokinetics of the insulin lispro protamin chaos are similar to that of average insulin, such as NPH. The pharmacokinetics of the Humalog Mix 75/25 is a combination of the separate pharmacokinetic properties of the two components. When considering the clinical dynamic of these dynamics, it will be more suitable when checking the curve to meet glucose consumption (as shown in the "Pharmacological Hoc Hoc" section).

insulin lispro maintains faster absorption than the dissolved human insulin in patients with renal failure. In patients with type 2 diabetes with many levels of renal function, noticeable about the kinetics between insulin lispro and insulin insulin is often maintained and indicates that regardless of renal function. In patients with liver failure, insulin lispro maintains absorption and excretion faster than dissolved human insulin.

Clinical safety data

In vitro tests, including attaching to the insulin receptor position and acts on growth cells, indicates that insulin lispro acts in a very similar way of human insulin. Studies also show that the insulin receptor bonding of insulin lispro is equivalent to human insulin. Acute toxic studies, a month and twelve months showed no significant toxicity.

Insulin lispro does not impair fertility, non -toxicity on embryos or monitoring in animal studies.

Before taking Humalog Mix 75/25 Kwixpen injection pen treat diabetes (5 trees x 3ml)

How to use

Each insulin injection pen should only be used for 1 patient even after changing needles to avoid the risk of infectious diseases.

Should turn the pen in the palm ten times and slope 180 ° ten times just before use to mix insulin until the uniform mixture is opaque or opaque white like milk. If not, repeat the above process until the substances are mixed. The pipe tube inside the pen contains a small glass to support the mixing. Do not shake vigorously because it can create foam that obstructs the dose.

Check the pipe regularly and not be used if the drug is clumped or there are white solid particles clinging to the bottom or the wall of the pipe, causing the drug to be covered with dew.

Operation with injection pens

Before using the pen, you need to read the instructions for the instructions for the injection pen that comes with the drug tutorial. Need to use the pen in accordance with the recommendations in the instructions for the use of pen.

Dosage

Dosage is determined by the doctor depending on the needs of each patient.

Humalog Mix 75/25 injection pen can be used right before meals. When needed, Humalog mix 75/25 can be used immediately after meals. Humalog mix 75/25 is only indicated for subcutaneous injection. In any case, it is not allowed to use Humalog mix 75/25 intravenous lines.

Should be injected under the skin on the arms, thighs, buttocks or abdomen. Should turn around the insulin injection so that it does not inject the same position more than once within a month.

When using subcutaneous injections, be careful when injection of Humalog Mix 75/25 to ensure no poking into the blood vessels. After the injection, do not massage the injection place. Must train patients with proficient use of injection techniques properly.

Observed the rapid and early active onset of the Humalog Mix 75/25 when subcutaneously injected. Thanks to that, Humalog mix 75/25 can be injected right next to the meal. The acting time of the Insulin Lisplo Protamin (basal) chaos in the composition of Humalog Mix 75/25 is similar to that of the background insulin (NPH).

The effect of insulin may vary between patients or at different times on the same patient. Like insulin preparations, the effect time of Humalog Mix 75/25 depends on the dose, injection location, blood flow, temperature, and physical activity.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Lower blood glucose may be the result of an over -active act of insulin compared to the amount of food and consumption energy.

Lower blood glucose can lead to listless, confused, brushed chest, headache, sweating and vomiting.

Mild blood glucose hypogs can be processed by taking glucose or sugar or saccharat products.

The treatment of severe severe blood glucose can be treated by intramuscularly or injecting under the glucagon skin, then eating or taking carbohydrates when the patient has completely recovered. Patients who do not respond to glucagon must be infusion of glucose solution.

If a patient has a coma, intramuscularly or under the skin of Glucagon. However, it is necessary to use intravenous glucose if there is no glucagon or if the patient does not respond to Glucagon. Patients need to eat immediately after awake.

Maintain the amount of carbohydrate and need to be monitored by blood glucose may reappear immediately after clinical recovery.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Humalog Mix 75/25, you may experience unwanted effects (ADR).

Lower blood glucose is the most unwanted effect of insulin therapy that patients with diabetes may encounter. Lowering severe blood glucose can lead to unconsciousness, and in the most severe case of death. There is no specific frequency of blood glucose, because blood glucose is a result of both insulin dose factors and other factors, such as the patient's diet and physical exercise.

Local allergies in patients are common (1/100 to

Atrophy of fat tissue in the injection area is not common (1/1,000 to

Cases of edema have been reported when using insulin therapy, especially when using enhanced insulin therapy to improve previous metabolic control.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Humalog Mix 75/25 contraindications in the following cases:

Hypersensitivity to insulin lispro or any excipients of the drug.

Lower blood glucose.

Be cautious when using

In any case, it is not allowed to use Humalog Mix 75/25 intravenous line.

The transfer of patients to use another type of insulin or other insulin brands need to be performed under tight medical supervision. Changes in concentration, brand (manufacturer), type (short effect, NPH, slow, etc.), species (animal insulin, human insulin, human substance similar to human insulin), and/or production methods (recombinant DNA compared to animal -based insulin) can lead to the need to change the dose.

The conditions that make the early warning symptoms of other blood glucose or less obvious including the time of prolonged diabetes, positive insulin therapy, diabetic neuropathy or taking drugs such as beta blockers.

Some patients with blood glucose reactions after transferring from animal -based insulin to insulin have reported early warning symptoms of lower blood glucose or different from the symptoms they have encountered when using the previous insulin. Hypoglyc or hyperlemia reactions that are not adjusted can cause unconsciousness, coma or death.

The use of insufficient doses or stop treatment, especially in diabetes dependent insulin can lead to hyperlem of blood glucose and diabetes acidosis due to diabetes, this condition is likely to be fatal.

Insulin needs can be reduced in the case of renal failure. Insulin demand can be reduced in patients with liver failure due to reduced glucose ability and decreased insulin decomposition; However, in patients with chronic liver failure, increased insulin resistance can lead to increased insulin demand.

Insulin demand may increase during illness or emotional disorders.

may also need to adjust the dose if the patient increases physical activity or changes the normal diet. Physical exercise right after a meal can increase the risk of blood glucose.

Should only use Linsulin Lislocho Children under 12 years old in case of more benefit than using normal insulin.

combination of Humalog mix 75/25 with pioglitazon

There have been reports on heart failure when Pioglitazon is used in combination with insulin, especially in patients with risk factors for developing cardiovascular diseases. It should be noted this, if considering the treatment of Pioglitazon combination with Humalog Mix 75/25. If used in combination, patients should be monitored with signs and symptoms of heart failure, weight gain and edema. Pioglitazon should be stopped if any symptoms of heart activity.

Special warning

The product is only for subcutaneous injection.

Read the instructions carefully before use. If you need more information, please consult your doctor.

Notify the doctor with unwanted effects when using the drug.

to be out of reach of children.

The drug is only used by a doctor.

The ability to drive and operate machinery

The patient's concentration and reaction ability may be impaired as a result of blood glucose. This can be dangerous in situations where these possibilities are of special importance (such as driving or operating machinery).

Advise patients to be cautious to avoid blood glucose while driving, which is very important in patients who are difficult to identify whether or not to recognize the warning signs of blood glucose or in people who often have blood glucose. Should consider whether or not to drive or not in these cases.

Pregnancy

Research data on a large number of pregnant women using insulin lispro does not show any adverse effects of the drug during pregnancy or for the health of the fetus/infant.

It is necessary to maintain good control of patients treated with insulin (diabetes dependent insulin or diabetes due to pregnancy) during pregnancy. Insulin demand usually drops in the first three months of pregnancy and increases in the middle and the last three months of pregnancy. It is necessary to advise patients with diabetes to notify the doctor if they are pregnant or intend to get pregnant. Monitoring blood glucose as well as general health is essential in patients with pregnancy with diabetes.

Breastfeeding period

Mothers with breast -feeding diabetes may need to adjust insulin dose, diet or both.

Medicinal interaction

Insulin demand may increase due to drugs that increase blood glucose such as oral contraceptives, corticosteroids, or thyroid hormones, Danazol, beta2 stimulants (such as ritodrin, salbutamol, terbutalin).

Insulin needs can be reduced due to drugs that have the effect of lowering blood glucose such as oral blood glucose medications, salicylate (for example, acetylsalicylic acid), sulpha antibiotics, some antidepressant drugs (Monoamine oxidase inhibitors, selective Serotonin re -inhibitors) (Captopril, Enalapril), Angiotensin II receptor blockers, beta blockers, ictreotid or alcohol.

Mixing Humalog mix 75/25 with other insulin preparations have not been studied.

Should consult your doctor when using other drugs with Humalog Mix 75/25.

Cavalry

There is no study on mixing Mix 75/25 with other insulin. When there is no study of compatibility, these drugs should not be mixed with other drugs.

Storage

Unused pen

Store in the refrigerator at 2 - 8 ° C. Do not freeze. Do not leave too hot or direct sunlight.

After first use

Storage below 30 ° C. Do not leave in the refrigerator. Remove needles from the pen in the injection pen during storage.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.