Human Albumin Baxter 200g/L injection solution is used in restoration and maintenance of blood volume (50ml)

Dosage form Box X 50ml
Specifications Human Albumin

Ingredient

Composition information	Content
Human Albumin	20%

Uses

Indications

Human albumin Baxter 20% 50ml solution is indicated in the following cases:

Used in the case of restoration and maintenance of blood volume in cases of hypoglycemia and the use of glue solution containing albumin is appropriate.

Priority to choose albumin or other artificial glue depends on the clinical condition of the patient, based on the official recommendations.

Physical and physical properties: Human Albumin Baxter 20% 50ml has a good effect on increasing glue pressure. The most important physiological function of albumin is to contribute to creating glue pressure in the blood and its transportation function.

Albumin contributes to stabilizing the volume of blood circulation, transporting hormones, enzymes, drugs and toxins.

Dynamic pharmacokinetics

Under normal conditions, the total amount of albumin can be exchanged is 4-5 g/kg in body quantities, of which about 40–45% in blood vessels, 55-60% outside the blood vessels.

Increasing capillaries can change the dynamics of albumin and abnormal distribution when severe burns, bacterial shock. Under normal conditions, albumin's waste sale time is 19 days.

Balancing the amount of synthetic albumin and degeneration according to the feedback mechanism. Excretion is mainly in the intracellular and lysosomal proteases.

In healthy people, less than 10% of albumin will escape from the blood vessels in the first 2 hours of infusion. There is a significant change between individuals in terms of blood volume.

For some patients, plasma volume can be maintained in several hours. However, for patients with serious illness, albumin may be released from blood vessels with significant quantities with unpredictable pace.

Before taking Human Albumin Baxter 200g/L injection solution is used in restoration and maintenance of blood volume (50ml)

How to use

Preparation can be used directly by intravenous or diluted line with isotonic solution (for example: 5%glucose solution, 0.9%sodium chloride).

The transmission speed must be consistent with the specific condition of each patient and as directed.

In case of plasma replacement, the infusion rate must be adjusted in accordance with the excretion speed.

Dosage

Dosage depends on the condition of each patient, the severity of the injury or the condition and the amount of fluid or protein of the body continue to lose. Check the volume of circulating and the degree of plasma albumin deficiency to determine the appropriate dose.

Human Albumin Baxter 20% 50ml solution needs intravenous infusion. Do not dilute the preparation with distilled water because it can cause hemolysis.

Do not mix albumin solutions with other drugs containing blood and blood components but can be used simultaneously with other injected preparations when really necessary.

Albumin solutions should not be mixed with hydrolyzed protein or alcoholic solutions because these substances combine can produce protein.

Do not add supplements to the infusion solution.

The increase in the vol Hemodynamic parameters should be monitored when patients use Human Albumin Baxter 20% 50ml and should check the risk of increased blood flow and circulating overload.

If the albumin is used, must continuously monitor the hemodynamic parameters including:

arterial blood pressure and heart rate.

Venous pressure.

pulmonary artery pressure.

Urine.

Concentration of electrolytes.

Hematocrit/hemoglobin ratio

Clinical signs of heart failure and respiratory failure (Example: shortness of breath)

Clinical signs of increased skull pressure (eg headache)

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? too high transmission.

Stop transmitting drugs as soon as the first clinical signs of circulatory overload (headache, shortness of breath, intravenous vein obstruction), or manifestations of hypertension, increased venous pressure, pulmonary edema, monitoring monitoring of patient hemodynamic parameters.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Human Albumin Baxter 20% 50ml you can experience unwanted effects (ADR).

rare, ADR

immune system disorders: Anaphylaxis.

Gastrointestinal disorders: Nausea.

Skin and subcutaneous disorders: rash, blush.

Common disorders and disorders at the infusion site: fever.

Unknown frequency

immune system disorders: Anaphylaxis, allergic reactions.

Nervous disorders: headache, change taste.

Cardiovascular disorders: tachycardia, atrial fibrillation, tachycardia.

Gastrointestinal disorders: vomiting.

Vascular disorders: Hypotension, flushing.

Respiratory disorders, chest and mediastinum: pulmonary edema, shortness of breath.

Skin and tissue disorders: urticaria, itching.

Common disorders and disorders at the infusion site: chills.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Human Albumin Baxter 20% 50ml Contraindicated in the following cases:

Hypersensitivity to albumin or any ingredients of the drug.

People with a history of allergies to albumin and any ingredients of the drug.

Be cautious when used

Do not dilute Human Albumin Baxter 20% 50ml with distilled water mixed by the injection because it can cause blood soluble. If you use distilled water to dilute the albumin of 20% or higher concentration, there will be a risk of death due to hemolysis or acute renal failure.

Allergic reaction/anaphylactic shock:

If there is a doubt of allergic reactions or anaphylactic reactions, immediately stop the transmission.

Measures to prevent infectious agents:

Standard measures to prevent infections from preparations derived from blood and plasma include selecting volunteers, screening donation samples and each plasma bag to find special signs of infection, bringing effective stages in the production process to be inactivated or eliminating viruses.

hemodynamics:

Do not conduct treatment without strict control of hemodynamics, need to check the evidence of heart failure/respiratory failure, kidney failure or intracranial pressure.

Increase blood volume/increase circulating flow:

Care especially when using albumin in cases of excess body fluid and the consequence of excess body fluid or when blood thinning will be dangerous to the patient. Initial clinical signs of increased circulatory flow include: headache, shortness of breath, neck veins, hypertension, central nerve pressure, pulmonary edema, need to stop transmitting drugs immediately.

Medicinal transmission with large volume:

If the replacement volume is relatively large, it is necessary to closely monitor the coagulation and hematocrit.

It is necessary to take appropriate hemodynamic monitoring measures in the transmission process.

Electrolyte status:

When transmitting albumin solution, it is necessary to closely monitor the concentration of electrolytes of the patient, taking appropriate measures to restore and maintain the balance of electrolytes.

should be cautious when treating in patients who are maintaining a sodium -controlled diet.

Blood pressure:

It is necessary to carefully observe the signs of hypertension after the 20% albumin transmission for patients with injury or after surgery to detect and treat serious blood vessels to avoid bleeding at lower blood pressure.

The ability to drive and operate machinery

There is no notice that albumin adversely affects the ability to drive and operate the machine.

Pregnancy

Because there is no enough research data on the use of albumin preparations (Human) for pregnant women, it is necessary to consider the risk and benefits when prescribing specified for pregnant women.

The period of breastfeeding

Consider the risk and benefits of prescribing prescribed in breastfeeding women.

Drug interaction

has not seen any special interactions between Human Albumin and other drugs.

Storage

Store at temperatures not exceeding 30 ° C. Do not freeze. Store in the original packaging to avoid light.

Other drugs

Disclaimer

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