Huntelaar 4mg Davi Pharm treat hypertension (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Lacidipine

Ingredient

Composition information	Content
Lacidipine	4mg

Uses

Indications

Huntelaar drugs are indicated in the following cases: Treatment of monochromatic hypertension or in combination with other antihypertensive drugs, including sympathetic beta blockers, diuretics and ACE inhibitors.

Pharmacokinus

lacidipine is a powerful calcium channel blocker of the dihydropyridine group and highly selected for calcium channel in smooth vascular muscle. The main effect of the drug is peripheral artery dilatation, reducing peripheral blood vessel resistance and reducing blood pressure.

pharmacokinetic

absorption

lacidipine is very oil body, quickly absorbed through the gastrointestinal tract after drinking. The average bioavailability is about 10% due to the first metabolic through strong liver. Plasma peak concentration is achieved after about 30 - 150 minutes.

Metabolism

There are 4 main metabolites but these metabolites may have less pharmacological effects. The drug is excreted mainly due to the metabolism through the liver (related to Cytochrome P450 CYP3A4). There is no evidence of induction or inhibition of liver enzymes of lacidipine.

Elimination

About 70% of the dose is eliminated in the form of metabolites through feces and the rest is metabolite through the urine. Lacidipine's exhaust time is about 13 and 19 hours in a stable state.

Before taking Huntelaar 4mg Davi Pharm treat hypertension (6 blisters x 10 tablets)

How to use

Oral drugs.

Should take the medicine at fixed hours a day, it is best to take medicine in the morning. Can take medicine with or without food.

Dosage

Starting dose

2mg x 1 time/day.

Treatment of hypertension should depend on the severity of the disease and the response of each patient. The dose can be increased to 4mg and if necessary to 6mg after a suitable time to get the sufficient pharmacological effects of the drug. In fact, this time is not less than 3 to 4 weeks unless clinical conditions require faster dose increase. Treatment period is not always fixed.

liver failure

lacidipine is mainly metabolized by the liver, so in patients with liver failure, the bioavailability of the drug can increase, leading to hypotension. The above patients must be carefully monitored, in some cases the dose is required.

kidney failure

No dose adjustment in patients with renal failure due to lacidipine does not excreted through the kidneys.

Children

No experience in lacidipine treatment for children.

Elderly

No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

No special antidote. Should use general measures to monitor heart function, supportive measures and appropriate treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Huntelaar, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: headache, dizziness.

Heart: Brushing chest drum, heartbeat.

digestive: discomfort in the stomach, vomiting.

Skin: rash on the skin (including erythema and itching).

Kidney - Urology: urine.

weakness.

Uncommon, 1/1000

Gastrointestinal: increased gums.

Rare, 1/10000

Heart: Severe angina does not determine the cause, fainting, hypotension.

skin: angioedema, urticaria.

Very rare, ADR

Neurology: Run.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Huntelaar medicine is contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Severe aortic stenosis, heart shock, myocardial infarction within 1 month, acute pain in stable angina, especially in unstable angina, porphyrin metabolism disorders.

Be cautious when using

Be alert to lacidipine capabilities that can cause uterine muscle relaxation after birth.

Specialized studies have shown that lacidipine does not affect the onset function of the SA button or causes the extension of the transmission in the AV button. However, in theory, the calcium channel blockers are likely to affect the operation of the SA and AV nodes, so lacidipine should be used cautiously in patients with abnormal history in the operation of the SA button and AV.

lacidipine should be used carefully in the following cases:

Patients who prolong congenital QT.

Patients treated simultaneously with drugs that extend the QT interval such as anti -arrhyths group I and III, three -ring antidepressants, some anti -psychotic drugs, antibiotics (such as erythromycin) and some antihistamine drugs (such as terfenadine).

Patients with poor heart reserves.

Patients with liver failure because it can increase the effect of hypotension.

patient unstable angina.

There is no evidence that lacidipine reduces glucose tolerance or changes in blood sugar control.

Should use caution in patients with myocardial infarction. After the beginning of treatment, if the pain of ischemia appears or the existing pain is severe, it is necessary to stop the drug.

Be careful to use lacidipine when the patient has heart failure or left ventricle function because heart failure may worsen. Must stop the medicine.

The ability to drive and operate machinery

lacidipine can cause dizziness. Patients should be warned that they should not drive or operate machinery if they feel dizzy or related symptoms.

Pregnancy

Calcium inhibitors in general inhibit uterine contractions in the early stages, but there is no evidence that the drug slows birth. However, the drug causes some complications such as causing fetal deficiency due to vasodilation, hypotension in the mother, reducing uterine perfusion and placenta.

There is no data on the safety of lacidipine in pregnant women.

lacidipine can cause uterine muscle relaxation during pregnancy, so it should be considered. Animal research does not show a teratogenic effect or slow the growth of the fetus.

Should only use lacidipine for pregnant women when the benefits bring mothers outstanding unwanted effects that can occur for the fetus or child emulsion.

Breastfeeding period

Animal research shows lacidipine (or its metabolic substances) distributed into breast milk.

Should only use lacidipine for nursing mothers when the benefits bring the mother outstanding unwanted effects that can occur for children.

Medicinal interaction

Use lacidipine with other drugs that have other hypotension such as diuretics, beta blockers or ACE inhibitors can increase the effect of lowering blood pressure. However, it is not possible to identify specific interactions in research with commonly used antihypertensive drugs (such as beta blockers and diuretic) or digoxin, tolbutamide or warfarin.

Lacidipine concentration in plasma may increase when used simultaneously with cimetidine.

lacidipine is highly linked to protein (more than 95%), including links with albumin and alpha-1-glycoprotein.

Do not drink lacidipine along with grapefruit juice by being able to change bioavaila.

In clinical studies in kidney transplant patients with cyclosporin shows that cyclosporin reduces lacidipine recovery in plasma streams through the kidneys and reduces the ratio of glomerular filtration.

lacidipine is metabolized by Cytochrome CYP3A4, so the CYP3A4 inhibitors and CYP3A4 induction substances are used simultaneously can affect the metabolism and elimination of lacidipine.

The effect of calcium dihydropyridine channel blockers may be reduced by anti -enzyme anti -epileptic drugs such as carbamazepine, phenobarbital and phenytoin, dihydropyridine may increase the level of phenytoin in plasma.

NSAID NSAID anti -inflammatory anti -inflammatory drugs: Indomethacin and other NSAID anti -inflammatory drugs may be opposed to the anti -hypertension effect of calcium channel blockers through prostaglandin synthesis inhibitors in the kidneys, or cause salt stasis and water.

Melatonin can cause lower blood pressure, so it can increase the ability to lower blood pressure if used with lacidipine.

Used with other calcium channel blockers: The concentration of each drug may increase due to the same metabolic path.

Storage

In a dry place, avoid light, the temperature does not exceed 30ºC.

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