Hydrocolacyl 5mg khapharco anti -inflammatory and immunosuppressant rheumatoid immunity, cancer (1000 tablets)

Dosage form 1000 tablets
Specifications Prednisolone

Ingredient

Composition information	Content
Prednisolone	5mg

Uses

Indications

Hydrocolacyl 5 mg drug is indicated in cases when it is necessary to anti -inflammatory and immunosuppressive effects:

Rheumatoid arthritis, all -body lupus, some vascular inflammation.

temporal artery inflammation and inflammation around the artery, sarcoid disease, bronchial asthma, ulcerative colitis, hemolytic anemia, granulocytosis and severe allergens including anaphylaxis. Japanese drugs, only 1 time in the morning in the 24 -hour natural secretion of corticosteroids will cause less side effects because of the recovery time between 2 doses. After long -term treatment, Prednisolon must be stopped in step.

Inflammation, whether in any disease, is characterized by leukocytes and infected with inflamed tissue. Glucocorticoids inhibit these phenomena. Glucocorticoid uses systemic sugars to reduce the number of lymphocytes, eosin blood cells, mononuclear leukocytes in peripheral blood and reduce their movement into inflamed areas. Glucocorticoid also inhibits the function of lymphocytes and macrophages of tissue.

In addition to the effect of the white blood cells, glucocorticoids also affect inflammation response by reducing prostaglandin synthesis due to phospholipase inhibition A2.

Glucocorticoid reduces capillary permeability due to inhibition of the activity of kinine and bacterial internal toxins and reduces the amount of histamine released by base leukemia.

pharmacokinetic

absorption

Oral bioavailability of Prednisolon is approximately 82%. Peak concentration in plasma is achieved from 1-2 hours after taking the drug.

Distribution

Prednisolon binds to plasma proteins about 90 - 95%. The clearance of Prednisolon is 8.7 ± 1.6 ml/min/kg. The distribution of the drug is 1.5 ± 0.2 liters/kg.

Metabolism

Prednisolon is metabolized in the liver and metabolites in the form of sulfate ester, glucuronid is excreted into the urine.

Elimination

Prednisolon waste time is approximately 1.7 - 2.7 hours.

Before taking Hydrocolacyl 5mg khapharco anti -inflammatory and immunosuppressant rheumatoid immunity, cancer (1000 tablets)

How to use

Sold -prescribed drugs, oral orally as directed by the doctor.

Dosage

Starting dose for adults

Can be from 5 - 60 mg/day, divided into 2-4 times.

Dose for children

Can be from 0.14 - 2 mg/kg/day, divided into 4 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Cushing syndrome, muscle weakness and osteoporosis, only occurs when long -term glucocorticoid use.

Handling

gradually reduce the dose and then stop the drug.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hydrocolacyl 5mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: Insomnia, nervousness is easily agitated.

digestion: Increase appetite, indigestion. Skin: Skin.

Endocrine and metabolism: diabetes.

nervous - muscle and bone: joint pain.

Eyes: cataracts, glaucoma.

Respiratory: Nosebleeds.

Uncommon, 1/1000

Central nerve: Dizziness, convulsions, mental disorders, fake brain, headache, mood change, mood, hallucinations, refreshment.

Cardiovascular: edema, hypertension. skin: acne, skin atrophy, bruising, hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, inhibition of pituitary -adrenal axis, slow growth, glucose intolerance, potassium - blood, alkaline infection, amenorrhea, water retention and sodium, hyperlem of blood glucose.

digestive: stomach ulcers - duodenum, nausea, vomiting, bloating, ulcerative ulcer, pancreatitis. nervous - muscle and bone: muscle weakness, osteoporosis, fracture.

Body: Hypersensitivity reaction.

Instructions on how to handle ADR

Acute indications, except leukemia and anaphylaxis, should use glucocorticoids at the lowest doses and in the shortest time of clinical effect.

After a long -term treatment with glucocorticoid, there is a possibility of inhibiting the hypothalamus - pituitary - adrenal gland, so it is imperative to reduce the dose of glucocorticoids step by step, instead of sudden stop. Prednisolon's dose reduction process may be applied as follows: Every 3-7 days decrease 2.5 - 5 mg until the physiological dose of Prednisolon is approximately 5 mg.

If the disease worsens when reducing the dose, increasing the dose of Prednisolon and then reducing the slower Prednisolon dose.

Applying treatment to avoid continuous contact with drugs with the same pharmacological effect. Using a single dose of the day causing less ADR than using doses of division of the day, Japanese insulating therapy is a good measure to minimize the inhibition of adrenal glands and minimize other side effects.

In Japan, every 2 days every 2 days in the morning. Monitor and periodically evaluate the parameters of osteoporosis, hemorrhage, glucose intolerance, eye effects and blood pressure.

Preventive gastric and duodenal ulcerative prophylaxis with antihistamine or proton pump inhibitors when taking high doses of corticosteroids.

All long -term patients with glucocorticoids need additional calcitonin, calcitriol and additional calcium to prevent osteoporosis.

Those who are likely to be immunosuppressive due to glucocorticoid should be warned about the possibility of infection.

Patients who are about to have surgery may have to use glucocorticoid supplements because of the normal response to stress that has been reduced due to the inhibition of hypothalamus - pituitary - adrenal glands.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hydrocolacyl 5mg contraindicated drug in the following cases:

Severe infections, except for bacterial shock and meningitis.

Knowing hypersensitivity to prednisolon.

Skin infections, fungi or tuberculosis.

is using a living virus vaccine.

Precautions when using

Use carefully in people with osteoporosis, newly connected people (intestines, blood vessels), mental disorders, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, using the lowest doses in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed.

When using high doses, it can affect the effect of vaccinations.

The ability to drive and operate machinery

Dizziness should be used carefully for drivers and machinery operation.

Pregnancy

Using prednisolon for a long -term body for the mother can lead to weight loss of babies. Using high -dose Prednisolon in the whole body can cause the risk of reducing the adrenal product in newborns. The use of this medication in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mothers and children.

Breastfeeding period

Prednisolon secretes breast milk with less than 1% dose and may not be clinically significant. Be careful when using Prednisolon for breastfeeding women.

Drug interactions

Prednisolon is a cytochrome P450 enzyme induction and is the substrate of the P450 CYP3A enzyme, so this drug affects the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconkol, ketoconon, ketoconone Rifampicin.

Phenytoin, Phenobarbital, Rifampicin and diuretics decreased blood potassium may reduce the effect of prednisolon.

Prednisolon can cause hyperlem of blood glucose, so the insulin dose is needed in diabetes patients.

Avoid simultaneous use of prednisolon with nonsteroidal anti -inflammatory drugs as it can cause stomach ulcers.

Storage

less than 30 ° C, cool dry place, avoid light.

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