Hyperium medicine for hypertension (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Rilmenidine

Ingredient

Composition information	Content
Rilmenidine	1mg

Uses

indications

Hyperium 1 drug is indicated in the following cases: hypertension treatment.

Pharmacological

Hyperium 1 is Oxazoline derivatives that have anti -hypertension properties, which affect both bone marrow structures and peripheral vascular structures.

Hyperium 1 has a stronger imidazoline receptor on the α2 - adrenergic receptor that helps to distinguish this drug from the reference α2.

The drug has an anti -hypertension effect depending on the dosage when considered on the rats of congenital hypertension. But this effect of the drug is not related to the central neurological pharmacological effects common to α2, unless the dose is higher than the anti -hypertension dose in animal. In particular, very little work shows sedative effects.

The dissociation between anti -hypertension effect and neurological effect is also confirmed on humans.

Hyperium 1 has an anti -hypertension effect on dosage on both systolic and diastolic blood pressure in both lying and standing positions. With treatment dose (1 mg/day oral or 2 mg/day divided into 2 times) Double blind studies compared to Placebo and reference drugs have proved the effect of anti -hypertension mild and medium levels. This effect is maintained for 24 hours and when exertion. These results have been proven in long -term treatment without developing drugs.

At 1 mg/day treatment, double blind studies compared to Placebo show that Hyperium 1 does not affect tests to check alertness. Frequency of side effects (drowsiness, dry mouth, constipation) is not different from when using Placebo.

In the treatment dose of 1 mg/day, double studies compared to the α2 homogeneous substances used for the reference dose with equivalent low voltage effect, seeing the frequency of side effects and the severity of these side effects in Hyperium 1 is significantly lower.

In the treatment dose, Hyperium 1 does not affect the function of the heart, does not cause salt water and does not disturb the metabolic balance:

Hyperium 1 continues to have a significant anti -hypertension effect 24 hours after taking the drug, reducing the peripheral resistance, but does not change the cardiac supply. The index of heart and physiological contraction of the heart is not affected.

Hyperium 1 does not cause hypotension, especially in the elderly, and does not interact with the physiological increase of heart frequency when exertion.

Hyperium 1 does not replace the kidney blood, the filtration speed of the glomerular or the filter number and does not affect the function of the kidney.

Hyperium 1 does not affect glucose metabolism (including diabetics in the whole group dependent insulin and does not depend on insulin), and does not affect lipid metabolism.

Dynamic pharmacokinetics

absorption

Fast: Plasma peak concentration (3.5 ng/ml) is achieved from 1.5 to 2 hours after taking a dose of 1 mg Hyperium 1.

Completely: Absolute bioavailability of the drug is 100%, no metabolism through the liver for the first time.

Hang Dinh: There is no significant change between individuals, taking medicine and food that does not change the bioavailability of the drug. There is no change in terms of drug absorption when used for treatment as recommended.

Distribution

The ratio is attached to plasma proteins below 10%. The distribution volume is 5 l/kg.

Metabolism

Hyperium 1 only metabolizes a small part, the metabolites are found in the form of traces in the urine, and these substances are metabolized by hydrolysis or oxidation of oxazoline ring. These metabolites do not have the activity of Alpha - 2.

Elimination

Hyperium 1 is excreted mainly through the kidney: 65% of the dose is excreted intact through the urine. The clearance in the kidney accounts for 2/3 of the total clearance.

The half -life is 8 hours and is not affected by the dose or when used continuously. Time of pharmacological effect is longer, strong anti -hypertension effect maintained 24 hours after drinking on hypertension patients used 1 mg daily.

Redenment use continuously, stable state reaches after 3 days of medication. Research on plasma concentrations shows a stable state maintained for more than 10 days. Long -term monitoring of plasma concentrations in patients with high blood pressure (treatment for 2 consecutive years) have determined the concentration of Hyperium 1 in plasma is kept stable.

In the elderly: Pharmacokinetics studies in elderly patients (over 70 years old) have shown that the half -life of the drug is 12 hours.

In people with liver failure: The half -life is 11 hours.

In people with renal failure: Because Hyperium 1 is excreted mainly through the kidneys, the elimination rate of the drug decreases proportional to the severity of the kidney failure. In patients with severe renal failure (clearing creatinine below 15 ml/minute), the half -life is about 35 hours.

Before taking Hyperium medicine for hypertension (2 blisters x 15 tablets)

How to use

Hyperium 1 drug used oral. Only for adults.

Dosage

recommended dose per day is one tablet, 1 time in the morning, before eating.

If after 1 month of treatment without a response, it may increase the dose to 2 capsules daily, divided 2 times (1 morning, 1 tablet in the evening).

Patients with renal impairment (with creatinine purification greater than 15 ml/minute): In principle, the dose must not be changed.

In all cases, the doctor must strictly follow the doctor's prescription.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Symptoms may be encountered in cases of overdose including significant hypotension and poor concentration (reducing alertness). In addition to gastric lavage, it is also necessary to treat with symptomatic medications. Hyperium 1 is only a small part.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Hyperium 1, you may experience unwanted effects (ADR).

Like all drugs, Hyperium 1 can cause unwanted effects, although not all patients have these effects,

These side effects are benign and fleeting at the dose of treatment. The most common side effects include: Inhuman, insomnia, drowsiness, anxiety, depression syndrome, sexual disorders, stomach pain, dry mouth, diarrhea, constipation, itching, rash, cramps, cold head, edema, fatigue when exertion.

Exceptions: The situation of hotness, nausea, hypotension with vertical posture accompanied by dizziness has been reported.

Instructions on how to handle ADR

If you see any unwanted effects not yet recorded here or these effects become heavier, please inform your doctor or pharmacist.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hyperium 1 contraindicated drug in the following cases:

Hypersensitivity to one of the ingredients of the drug.

severe depression.

Severe kidney failure.

Coordinate with Sultopride.

Do not use this drug in combination with: alcohol, beta blockers used in heart failure (bisoprolol, carvedilol, metoprolol).

Be cautious when using

never stopped the drug suddenly, gradually reducing the dose.

When treating should be monitored regularly by a doctor.

Avoid drinking alcohol during treatment.

report to the doctor if you have severe kidney failure or recently detected heart disease.

If doubted, please consult a doctor or pharmacist.

The ability to drive and operate machinery

may be at risk of drowsiness if used overdose or taking the same drugs that may reduce alertness.

Pregnancy

avoid using Rilmenidine during pregnancy. Tell your doctor if you are pregnant.

breastfeeding period

recommendations not to use Rilmenidine for nursing women. Tell the doctor if you are breastfeeding.

Drug interactions

To avoid the possible interactions when taking many special drugs with sultopride, alcohol and beta blockers used in heart failure (bisoprolol, carvedilol, metoprolol), need systematic reporting to your doctor if taking other drugs.

Storage

Store less than 30 ° с.

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