Hypravas 20 Medisun treats hyperlestol, atherosclerosis (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Pravastatin

Ingredient

Composition information	Content
Pravastatin	20mg

Uses

indications

Hypravas is indicated in the following cases:

blood cholesterol treatment

HMG - COA Reductase inhibitors (Statin group) are appointed to complementary food therapy to reduce total cholesterol levels and LDL cholesterol in patients with primary hypercholesterol (type IIA and IIB) triglycerides).

Priest Prevention (level 1) Coronary events

In people with hypercholesteroly blood hyperplasia without clinical manifestations of coronary artery, indicating HMG - coa reductase inhibitors to:

Reduce the risk of death from cardiovascular disease.

Reduce the risk of coronary coronary regeneration procedures.

atherosclerosis

In patients with hypercholesterolemia, clinical manifestations of coronary artery disease, including previous myocardial infarction, indicated HMG - Coa Reductase inhibitors to:

Slow the progression of coronary atherosclerosis.

Reduce the risk of acute coronary events.

Competitive inhibitors with HMG-Coa Reductase, preventing HMG-CAA into Mevalonic Acid, an early precursor of cholesterol.

Pravastatin inhibits cholesterol biosynthesis and reduces cholesterol in liver cells. This stimulates the synthesis of LDL receptors on the liver cell membrane, thus increasing the clearance of LDL from circulation.

also reduces the level of VLDL, Triglycerides and HDL increases. The final result of this biochemical process is to reduce cholesterol levels in plasma. At normal doses, HMG-Coa Reductase is not completely inhibited, so there is still enough meevalonic acid for many metabolic processes.

In addition, statin also has anti -atherosclerotic effects. Most have proved to slow down the process of progress and/or retreat atherosclerosis and/or carotid arteries. The current mechanism of action is not fully known, but this effect can be independent of the effect of regulating blood lipids.

Dynamic pharmacokinetics

absorption

Pravastatin is absorbed quickly and is not affected by food. Low is low because of the first metabolic for the first time in the liver (> 60%). Time to reach the peak concentration in the serum of pravastatin from 1 to 1.5 hours.

distribution

Pravastatin binds to plasma proteins about 55 - 60%, more likely water pills should not pass through the brain blood barrier.

transformation

Pravastatin metabolizes mainly in the liver into active or no activity metabolites.

Elimination

The drug is eliminated in feces, excreting through the kidneys is about 20%. Selling time from 1.5 to 2 hours.

Before taking Hypravas 20 Medisun treats hyperlestol, atherosclerosis (6 blisters x 10 tablets)

How to use

Hypravas tablets for oral tablets, can be taken at meals or hungry.

Dosage

Starting dose 10 to 20 mg, once a day at bedtime. Adjust the dose every 4 weeks, if needed and tolerated. Maintenance dose of 10 - 40 mg/day once at bedtime.

Note:

Adjust the dosage according to the needs and response of each person by increasing the dose of each time apart from less than 4 weeks, until the desired cholesterol - LDL concentration is reached, or when the maximum dose is reached.

Because the synthesis of cholesterol in the liver occurs mainly at night, taking drugs in the evening will increase the effect of drugs.

Medicine combination: Pravastatin and bile acid -mounted plastic (Cholestyramin, Colestipol) have a supplementary mechanism for each other; Combining these groups of drugs has a plus effect on LDL cholesterol. When using statins along with bile acid -mounted plastic, such as cholestyramin, the statin must be taken at bedtime, 2 hours after taking the plastic to avoid clear interaction due to the drug attached to the plastic. Restricting statin coordination with other lipid medications because of the ability to increase muscle disease.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? No patient has special symptoms and all patients recover without sequelae.

If an overdose occurs, symptomatic treatment and support when necessary. Due to the strong drug associated with plasma proteins, the hemorrhage does not expect to significantly increase the clearing of pravastatin.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Hypravas 20 Medisun 6x10, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, constipation, flatulence, abdominal pain and nausea, about 5% of patients.

central nervous system: headache (4 - 9%), dizziness (3 - 5%), blurred vision (1 - 2%), insomnia, depression. nervous - muscle and bone: muscle pain, joint pain. liver: The test results of liver function increases more than 3 times the upper limit of normal, in 2% of the patient, but mostly have no symptoms and recover when stopping the drug.

Uncommon, 1/1000

Neurological - muscle and bone: muscle disease (combining muscle weakness and increased content of plasma creatin phosphokinase (CPK).

DA: Ban Da.

Respiratory: rhinitis, sinusitis, sore throat, cough.

rare, ADR

Central nervous system: Cognitive impairment (such as dementia, confusion).

nerve - muscle and bone: muscle inflammation, muscle pattern, leading to secondary acute renal failure due to myoglobin urine.

Endocrine: Increase HBA1C and serum glucose levels. Can increase the risk of diabetes development.

Instructions on how to handle ADR

Patients with high serum transaminase concentration must monitor the second liver function test to confirm the results and monitor treatment until the abnormalities return to normal. If the serum transaminase concentration of AST or ALT (GOT or GPT) persists in more than 3 times the upper limit of normal, it is necessary to stop treating with statin.

Advice patients to use statin immediately report any manifestation such as muscle pain for unknown reasons, sensitivity and muscle weakness, especially if accompanied by discomfort or fever. Statin therapy must be stopped if the CPK concentration increases significantly, 10 times higher than the upper limit of normal and if diagnosed or suspected is muscle disease.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hypravas drugs are contraindicated in the following cases:

Hypersensitivity to HMG-COA Reductase inhibitors or any ingredients of the preparation.

Be cautious when using

need liver enzyme test before starting statin treatment and in case of clinical indications that test requirements. Consider monitoring Creatine Kinase (CK) in the case:

Before treatment, CK tests should be conducted in the following cases:

impaired renal function, weakness, muscle toxicity with fibrat or statin, a history of yourself or a family history of genetic diseases, a history of liver disease and/or drinking a lot of alcohol, people older than 70 years old have elements of muscle and muscle, the possibility of drug interactions and some special patients. By pravastatin.

During the patient's statin treatment, the patient should notify when there are muscle manifestations such as muscle pain, muscle, muscle weakness ... When there are these manifestations, patients need to do CK test to take appropriate interventions.

Before starting treatment with pravastatin, it is necessary to eliminate the causes of blood cholesterol such as under -control diabetes, thyroid disobol, nephrotic syndrome, blood protein disorders, biliary liver disease, due to some other drugs, alcoholism and quantification of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides. Periodic lipid quantification must be conducted, with a distance of less than 4 weeks, and adjust the dosage according to the patient's response to the drug. The goal of treatment is to reduce LDL cholesterol so it is necessary to use LDL cholesterol levels to start treatment and evaluation of treatment.

Pravastatin therapy must be suspended or stop in any patient who shows signs of acute and severe muscle disease or has risk factors prone to acute renal failure due to muscle pattern, such as severe acute bacterial infections, hypotension, surgery and large trauma, unusual metabolism, hormonal, electrolytes or uncontrolled convulsions.

Only use pravastatin for women of reproductive age when they are certainly not pregnant and only in the case of hyperlestoly blood cholesterol very high without responding to other drugs.

The ability to drive and operate machinery

because when using the drug may experience some unwanted effects such as: Awareness impairment (such as memory loss, confusion ...), headache, dizziness, blurred vision should be cautious when used for drivers and operating machinery.

Pregnancy

Contraindicated use of pravastatin during pregnancy.

The period of breastfeeding

contraindicated use of pravastatin in nursing mothers.

Drug interaction

Increased risk of muscle lesions when using simultaneously pravastatin with gemfibrozil, other fibrats, high -dose niacin, colchicine.

Simultaneous use of pravastatin with HIV and HCV medications can increase the risk of muscle damage, the most serious is muscle pattern, kidney damage leading to kidney failure and may cause death.

Pravastatin is suitable for Darunavir + Ritonavir, Lopinavir + Ritonavir unlimited dose.

Pravastatin may increase the effects of warfarin. Prothrombin must be determined before starting the medication and monitoring regularly in the early stages of treatment to ensure no change in prothrombin time.

Bile acid -mounted resins can significantly reduce pravastatin's bioavailability when taken. So the time to use these 2 drugs is far apart.

Storage

Where dry, temperatures are below 30 ° C.

Expiry date: 36 months from the date of production.

Do not use overdue drugs indicated on the packaging.

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