Hyvalor 80mg United medicine for hypertension, heart failure (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Valsartan

Ingredient

Composition information	Content
Valsartan	80mg

Uses

indications

Hyvalor 80 drugs are indicated in the following cases:

Treatment of hypertension (single therapy or other combination of drugs).

Treatment of heart failure (degree II - IV according to NYHA classification).

Treatment of patients after stabilized myocardial infarction or left ventricular dysfunction. Renin-Anotensin, with vasoconstrictor effects, synthesized and released aldosterone, stimulates the heart and reabsorbs sodium in the kidneys. Valsartan operates selectively on the AT1 receptor, this receptor controls the activity of Angiotensin II.

Valsartan promotes vasodilation and reduces the influence of aldosterone by preventing the cohesion between Angiotensin II and AT1 receptors such as blood vessel muscles and adrenal glands. Valsartan has more affinity for AT1 receptors (about 20,000 times) than the AT2 receptor. Angiotensin II concentration increases in plasma after Valsartan blockade the AT1 receptor can activate the AT2 receptor. The metabolites of Valsartan are an inactive, affinity with AT1 receptor just 1/200 times compared to Valsartan.

ACE also acts as a catalyst in the process of degreing Bradykinin. Because Valsartan does not inhibit ACE, it does not affect the response of Bradykinin.

Although this clinical difference is not well known, Valsartan does not bond or blockade receptors of other hormones and ion channels that play an important role in the cardiovascular regulating mechanism. The Angiotensin II classe inhibits Angiotensin's reconciliation feedback mechanism to the excretion of renin, however, increasing the renin activity in plasma and angiotensin II concentration within the circulation does not overcome the low voltage effect of Valsartan.

Dynamic pharmacokinetics

absorption

After drinking, Valsartan is quickly absorbed. Valsartan plasma concentration peaks after 2 to 4 hours from drinking. Valsartan's absolute bioavailability is estimated at 23%. With tablets, food reduces a 40% AUC and reduces cmax by about 50%. The sale time of the drug is about 5 to 9 hours, with people with kidney failure is 6.6 hours. Valsartan does not accumulate significantly in plasma with the dose.

distribution

The distribution voltage in the stable stage after a small intravenous dose (17 l), shows that Valsartan is not widely distributed into the tissues. Valsartan has high serum protein binding ability (94 - 97%), mainly serum albumin.

transformation

The metabolic enzyme for Valsartan has not been determined, but may not be due to the cytochrome P450 enzyme. Valsartan is negligible and excreted mainly through the biliary tract in the constant form.

Elimination

The elimination mainly in fertilizer (83%) and urine (13%). Patients with dialysis do not eliminate Valsartan.

Multi -dose treatment studies in patients with hypertension with stable renal failure and kidney artery stenosis, Valsartan has no significant clinical effects on glomerular filtration, creatinine clearance or plasma flow at the kidneys.

Before taking Hyvalor 80mg United medicine for hypertension, heart failure (3 blisters x 10 tablets)

How to use

Hyvalor 80 drug used by oral.

Dosage

conventional dose in case of hypertension:

Initial and maintenance dose in adults: Take 1 tablet Hyvalor 80 mg once daily with monomers in patients with no reduction in the volume of circulating.

Common dose in case of patients with heart failure:

The recommended starting dose in adults: 40 mg every 12 hours. Should consider reducing the dose if combining diuretic.

can start early 12 hours after myocardial infarction.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The most common manifestation of overdose is probably hypotension and tachycardia, which may also experience slow heart rate due to sympathetic nerve stimulation (vagus nerve); Dizziness, dizziness or fainting. If symptoms of overdose occur, symptomatic treatment and immediate support treatment.

If symptomic hypotension occurs, the patient should be placed in the back, low head, intravenously sodium chloride solution 0.9%.

Overdose management depends on the time of overdose, manifestation and severity of symptoms, but the most important measure is hemodynamic stability for patients.

Hemorrhage does not eliminate Valsartan.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Hyvalor 80, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: dizziness, dizziness, fatigue, headache.

kidney: increased blood urea.

Uncommon, 1/1000

Cardiovascular: lower blood pressure, posture hypotension, fainting.

Endocrine and metabolism: hyperkalemia.

digestive: diarrhea, abdominal pain, nausea, abdominal pain. blood: neutrophils.

Muscle muscle: joint pain, back pain.

eyes: blurred vision.

Kidney: Hypergenin increased blood, kidney dysfunction. Respiratory: dry cough. Other: viral infection.

rare, ADR

Immune: allergic reactions, itching, skin rash, anaphylactic reaction, angioedema, increased sensitivity to light, hair loss.

Blood: Anemia, small cell anemia, hematocrit/hemoglobin, platelet reduction. nerve: anxiety, drowsiness, insomnia, paresthesia, helplessness. digestive: Anorexia, dry mouth, taste disorders, constipation, indigestion, flatulence, vomiting.

Respiratory: Difficulty

liver: Hepatitis, increased liver function test indicators. nervous - skeletal muscle: muscle, muscle pain, acute muscle pepper. Cardiovascular: Brushing chest drum, chest pain.

Instructions on how to handle ADR

During the controlled clinical research in people with hypertension, the ADR is equivalent to the Valsartan treatment group and the Placebo group. ADR frequency does not depend on the dose, treatment time, age, gender or ethnicity.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Hyvalor 80 drug contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Pregnant women: The drug acts on the Renin-Anotensin system during the 3 months between and the last 3 months of pregnancy causes fetal renal function, increasing fetal and infant mortality. Stop using the drug as soon as you detect pregnancy.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Hypotension: Excessive lower pressure rarely occurs (0.1%) in patients single therapy with uncomplicated hypertension. Often occurs in patients with decreased volume and/or reduced salt is being treated with high doses.

impaired liver function, cirrhosis, biliary obstruction: Most Valsartan are eliminated in bile, patients with mild to medium liver failure, including patients with biliary obstruction disorders that show lower valsartan clearance. Pay attention to these patients when using.

Improving kidney function-blood pressure: No research on the use of Valsartan for a long time in patients with kidney stenosis on one side or both sides, but the effect is similar to ACE inhibitors that need prognosis.

The consequences of the inhibition of the renin-anidensin-andosterone system that changes the kidney function can be predicted in sensitive patients. On patients with severe heart failure, renal function may depend on the renin-angiotensin-aldosterone system, so it can lead to an urinary and/or hyper urea hyperkemis progression and (rare) with acute and/or death.

Older people can increase the effectiveness of the drug, especially affect the kidneys. Be careful with patients with severe renal impairment with creatinine clearance ratio

The ability to drive and operate machinery

Persons who often drive or operate machinery should use Hyvalor 80?

The drug can cause dizziness, do not operate machinery or drive when taking the drug.

Pregnancy

Women during pregnancy should use Hyvalor 80?

Contraindicated to use Valsartan for pregnant women during the three months between and the last three months of pregnancy.

There is no recommendation to use Valsartan in the first three months of pregnancy.

When detecting pregnancy, the patient is being treated with Valsartan should stop immediately and replace it with other drugs. If you have used Valsartan for a long period of three months in the middle of pregnancy, it is necessary to have an ultrasound to check the kidney function and the fetal skull. Babies whose mothers use Valsartan during pregnancy should be closely monitored by the risk of hypotension.

Demonstrate period

Women who breastfeeding should use Hyvalor 80?

It is not known whether Valsartan is excreted through breast milk or not. However, Valsartan is distributed in breast milk. Because the risks may occur unwanted effects in breastfeeding, it is recommended not to use medication when breastfeeding.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Diuretic: Increases side effects of hypotension.

Potassium drugs, potassium -containing preparations: increases blood potassium concentration.

warfarin: may increase prothrombin test.

Non-Stoid anti-inflammatory drugs: may impair kidney function, which can cause acute renal failure.

Lithi salt: may reduce lithium clearance, control of lithium concentration in serum.

Storage

In a dry place, avoid light, temperature below 30 ° C.

Expiry date: 24 months from the date of production.

Do not use overdue drugs indicated on the packaging.

Manufacturer: United International Pharma Co., Ltd.

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