Ibartain mr 150mg Vellpharm treat high blood pressure (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Irbesartan

Ingredient

Composition informationContent
Irbesartan150mg

Uses

indications

Ibartain mr 150mg medicine indicated for high blood pressure treatment, can be used separately or/and used in combination with other high blood pressure treatments.

Pharmacology

Medicines belonging to the Angiotensin-II receptor antagonist group (Ang II), which can inhibit Ang I transformed into Ang II, it has a special antagonism with the elasticity of blood vessels that convert the receptor enzyme 1 (AT1), the antagonistic effect with AT1 is 8500 times larger

Medicines inhibit blood vessel elasticity and release Aldosterone, lowering blood pressure. The drug does not inhibit enzyme conversion blood vessel elasticity (ACE), kidneys and other receptor hormones; The drug also does not inhibit the path related to the adjustment of blood pressure and sodium balance.

Mechanism of action:

Irbesartan is an Angiotensin II receptor antagonist II. Irbesartan has the same effect as Losartan, but not as a pharmaceutical substance like Losartan, so the pharmacological effect does not depend on the hydrolysis of the liver.

Irbesartan sealed the physiological activity of angiotensin II is the substance made from Angiotensin I in catalytic reaction by Angiotensin (ACE Kininase II).

Angiotensin II is the main vasoconstrictor of the renin-angiotensin system and also stimulates synthetic adrenal skin and secretion of aldosteron. When aldosteron is released, sodium and water will be reabsorbed, finally hypertension.

Irbesartan claims the effect of vascular shrinkage and aldosteron excretion of Angiotensin II thanks to selective attachment to the ANOTENSIN II's ATJ receptor with 8500 times stronger than attaching to the AT2 receptor.

AT2 receptor is also present in many tissues, but does not play a role in the cardiovascular air conditioner.

pharmacokinetics

Good absorption preparation after drinking, bioavailability is 60 ~ 80%, not affected by food.

Single -dose TMAX is 3.9 hours, CMAX is 1.4 μg/ml, the combination of plasma albumin is 90%, the filtration ratio of the kidney is about 0.07 l/hour. Irbesartan metabolizes via acid-and oxidant or oxidant glucus, in vitro tests showing mainly due to enzyme oxidation (enzyme cytochrome) P450 2C9.

Preparations and metabolites are excreted through the liver and kidneys.

Before taking Ibartain mr 150mg Vellpharm treat high blood pressure (3 blisters x 10 tablets)

How to use

Ibartain mr 150mg tablet tablets for oral.

Dosage

Dosage recommended for starting treatment with a amount of 0.15 g, once a day.

Depending on the condition, adjust the amount of drug to 0.3 g, once a day; Can be used separately or/and used in combination with other high blood pressure.

Hypertension is severe and after taking the drug with an increase in blood pressure, it has not decreased according to the desire, you can use additional diuretics in small amounts (such as the thiazide group) or other blood pressure drops.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects when using Ibartain MR 150mg that you can meet.

The common reaction is headache, dizziness, heart beating fast, sometimes cough.

The disease is normal, the above reactions are mild, fleeting; Most patients persevere in taking drugs can withstand. Urticaria and edema rarely occur.

According to the report shows that the rate of side effects of the drug occurs at 1%, sometimes: digestive disorders, heartburn, diarrhea, muscular pain, fatigue and upper respiratory infection; But there is no clear difference compared to the reference team such as abdominal pain, anxiety, chest pain, sore throat, vomiting, eczema disease, fast heart palpitations, low blood pressure generation and low blood pressure on duty of about 0.4%.

Instructions on how to handle ADR:

The ADR is rarely occurring, usually light does not need any special treatment. If you start taking the drug, you should pay attention to reducing blood volume if any.

With mild adverse reactions, usually just stop the drug.

In case of severe sensitivity or allergic reactions, supportive treatment (airy keeping and using epinephrin, oxygen breathing, antihistamine, corticosteroids ...).

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ibartain mr 150mg contraindications in the following cases:

  • Not used for cases of sensitivity to the drug.

    • Be cautious when using

    Before starting treatment, blood and sodium must be checked.

    Patients with renal function may reduce the amount of drug and pay attention to the change of nitrogen nitrogen in the blood, serum tendons and potassium in the blood; Making results of kidney elasticity blood vessels inhibiting Aldosteron.

    For people who are sensitive to drugs, liver function changes.

    Patients with liver function, high age when using drugs without adjustment.

    Irbesartan cannot be excreted through dialysis.

    Effects of drugs on drivers and machinery operate

    Precautions when using the drug.

    used for pregnant and lactating women

    pregnancy:

    Do not use for pregnant and lactating women.

    Breastfeeding period:

    Do not use for pregnant and lactating women.

    Interactive drug

    When taking the drug in combination with diuretics, attention must be paid to blood volume or low sodium, leading to low blood pressure. When used in conjunction with diuretics to ensure potassium (such as triamterene), it should be avoided to increase potassium in the blood.

    Interaction between drugs and unclear warfarin.

    Used in combination with drugs belonging to the digitalis group such as digoxin, beta blockers such as Atenolol, antagonists like Nifedipine does not affect each other's pharmacokinetics.

    Storage

    In a dry place, avoid light, temperature below 30 ° C.

    Other drugs

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