Ibrafen OPV drugs for headache, fever for children (60ml)

Dosage form Drink
Specifications Bottle x 60ml
Ingredient Ibuprofen
Indication Fever, dysmenorrhea, headache, joint pain, inflammation, toothache
Contraindication Hepatic failure, kidney failure, heart failure

Ingredient

Composition information	Content
Ibuprofen	100

Uses

indications

Ibrafen drugs are indicated in the following cases:

for children from 3 months to 12 years old with symptoms: Mild to medium pain, post -vaccination fever, rheumatism or muscle pain, headache, fever, sore throat, toothpole, toothache, mild pain, cold symptoms and flu. Fruit by inhibiting prostaglandin synthesis in humans. Ibuprofen reduces pain, swelling and inflammation. Moreover, ibuprofen inhibits platelet collection.

Experimental data shows that ibuprofen can inhibit the effects of low -dose aspirin on platelet aggregation when used simultaneously. In a study, when taking a single dose of ibuprofen 400 mg within 8 hours before or within 30 minutes after taking the dose of aspirin (81 mg) instantaneous release, the effect of aspirin in the formation of thromboxan decreased or a plateletic collection occurred.

However, data limitations and uncertainty related to ex-Ex-vivo data for clinical situations show that it is impossible to make a certain conclusion for regular ibuprofen use. Besides, there is no clinical significance that is considered to be capable of using ibuprofen occasionally.

Pharmacokinetics

absorption

ibuprofen is quickly absorbed in the digestive tract and quickly distributed throughout the body. The peak concentration of plasma is reached for about 1 to 2 hours after drinking with a meal or for 45 minutes if taken at an empty stomach. These times may vary with different forms of preparation.

Distribution

ibuprofen is strongly connected to plasma proteins. In limited studies, ibuprofen appears in breast milk with very low concentrations.

Metabolism, excretion

ibuprofen is converted into two non -active metabolites and they are quickly excreted through the urine. About 1% of ibuprofen is excreted in the urine in a constant form and about 14% ibuprofen in the form of combined. Excretion quickly and completely through the kidneys. The sale time is about 2 hours.

Before taking Ibrafen OPV drugs for headache, fever for children (60ml)

How to use

oral medication. Short -term use.

Dosage

Children from 3 months to 12 years old

Do not use for children weighing less than 5 kg. For pain and fever - 20mg/kg/day divided into several times.

infants 3 - 6 months

2.5 ml, 3 times/day. Do not use more than 24 hours.

Babies 6 - 12 months

2.5 ml, 3 times/day.

Children 1 - 2 years old

2.5 ml, 3-4 times/day.

Children 3 - 7 years old

5 ml, 3-4 times/day.

Children 8 - 12 years old

10 ml, 3-4 times/day.

Doses should be used every 6 - 8 hours apart if necessary, and the distance between 2 times of drug use is at least 4 hours apart.

Fever after vaccination

2.5 ml (50 mg), after 6 hours, use an additional dose of 2.5 ml (50 mg) if necessary. No more than 2 doses in 24 hours.

If the fever does not decrease, consult a doctor.

Do not use for children under 3 months old.

For children 3 - 5 months old

If the child's symptoms worsen or if the symptoms last more than 24 hours, consult a doctor.

For children 6 months of age and older

If symptoms worsen or if symptoms last for more than 3 days, consult a doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

In adults, the effect of responding to less clear doses.

Selling time for overdose is 1.5 - 3 hours.

Symptoms

Most patients who have taken NSAIDs are clinically needed to cause nausea, vomiting, epigastric pain, or rarely diarrhea. Tinnitus, headache and gastrointestinal bleeding can also occur. In more serious poisoning, toxicity is seen in the central nervous system, manifested as drowsiness, sometimes stimulated and disoriented or coma. Sometimes the patient progresses to convulsions.

In serious poisoning, metabolic acidosis may occur and the time prothrombin/INR may be prolonged, possibly due to the intervention of activities of circulating blood clotting factors. Acute renal failure and liver damage. The severity of asthma can occur for asthma.

How to handle

should treat symptoms and support, including maintenance of airy airway and tracking signs of heart and vital signs until stable. Consider the use of oral activated carbon when patients take the amount of drugs that are likely to be toxic within 1 hour. If convulsions are regular and prolonged, it is recommended to be treated with diazepam or lorazepam intravenously. Use bronchodilators for asthma.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ibrafen, you may experience unwanted effects (ADR).

Stop medication and find medical assistance immediately if the child has manifestations

blood in the stool. Black stool.

vomit with bleeding or dark seeds like ground coffee.

Wheezing for unknown reasons, shortness of breath, rash (maybe serious and including blistering or skin peeling), itching or bruising, lightheaded heart, fast heartbeat, water retention (such as swollen ankles, little urine).

Hard neck, headache, nausea, vomiting, fever and disorientation.

Stop the medicine and notify the doctor if the child has manifestations

Abdominal pain, indigestion, heartburn, nausea and/or vomiting.

Gold and/or leather, may be a sign of liver problems.

Severe throat and high fever.

unknown bruises, bleeding or fatigue or infection (such as colds) than usual.

Hypersensitivity reactions that have been reported may include

Anaphylaxis and non -specific allergic reactions. The following undesirable is related to those who have used ibuprofen at non -prescribed doses, in a short time. In the treatment of chronic diseases, long -term treatment, other side effects may occur.

Common ADR> 1/100

Digestive: Unwanted effects occur in the stomach - intestines.

Uncommon: 1/1000

Hypersensitivity reactions: urticaria and itching.

digestive: abdominal pain, nausea and indigestion.

Nervous system: headache.

Rare: 1/10000

Digestive: diarrhea, flatulence, constipation and vomiting.

Very rare: ADR

Digestive: stomach ulcers, perforation or gastrointestinal hemorrhage, black stools, vomiting blood, sometimes fatal, especially in the elderly. Mouth ulcers, gastritis. The seriousness of colitis and Crohn's disease.

Nervous system: sterile meningitis.

Serious hypersensitivity reactions: swelling of the face, tongue and laryngeal, shortness of breath, tachycardia, hypotension. liver: liver disorders. kidney: Acute renal failure, kidney necrosis, especially when used for long -term, related to hyperemia and edema.

Hematology: Disorders of hematopoietic disorders (anemia, leukopenia, thrombocytopenia, hypoglycemia, granulocytosis). The first signs are: fever, sore throat, mouth ulcers, influenza symptoms, serious depression, unexplained bleeding and bruising.

Skin and subcutaneous tissue disorders: Serious skin reactions such as water balls, including Stevens-Johnson syndrome, diverse roses and poisoned epidermal necrosis.

Unknown frequency

Skin and subcutaneous tissue disorders: Drug reactions with acidic leukemia and systemic symptoms (Dress syndrome).

The immune system: In patients with autoimmune disorders (such as all -body lupus and connective tissue) when treating with ibuprofen, observing the single cases of sterile meningitis symptoms such as stiff neck, headache, nausea, vomiting, fever or disorientation.

Cardiovascular and cerebral vascular: edema, hypertension and heart failure have been reported to be concerned with NSAID treatment.

Risk of cardiovascular thrombosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ibrafen is indicated in the following cases:

Hypersensitivity to ibuprofen or any ingredients of the drug.

Patients with a history of hypersensitivity (such as asthma, rhinitis, angioedema or urticaria) with aspirin or other nonsteroidal anti -inflammatory drugs.

Are or have a history of ulcer/recurrence of stomach bleeding (two or more ulcers or separate bleeding).

History of bleeding or perforation of stomach-related stomach related to the use of nonsteroidal anti-inflammatory drugs (NSAID).

Severe heart failure, liver failure or kidney failure.

The last three months of pregnancy.

Be cautious when using

Unwanted effects can be minimized by using the lowest doses effectively in the shortest treatment period to control symptoms. Elderly people have increased the frequency of adverse reactions with NSAID, especially perforation or gastrointestinal bleeding can be fatal.

Respiratory

Bronchospasm can be seen in patients with disease or a history of bronchial or allergies.

other nsaids

Avoid simultaneous use of ibuprofen with other NSAIDs including selective inhibitors Cycloxygenase-2. Lupus erythematatodus and mixed connective tissue: increased risk of sterile meningitis.

Kidney

Kidney failure because kidney function can deteriorate.

liver

Liver dysfunction.

Effects on the heart and blood vessels

Be careful (discuss with a doctor or pharmacist) before starting to treat in patients with a history of hypertension and/or heart failure due to water retention, hypertension, edema that has been reported related to nsaid.

Heart thrombosis

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, can increase the risk of cardiovascular thrombosis, including myocardial and diverse infarction, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear. In order to minimize the risk of adverse incidents, Ibrafen is required at the lowest daily doses in the shortest possible time as possible.

Perpetual fertility in women

Evidence is limited, the cyclo-oxygenase inhibitors/prostaglandin synthesis can impair fertility in women due to ovulation. This can recover when discontinued. Therefore, using ibuprofen is not recommended for women who are trying to conceive.

digestive

Use NSAID carefully for patients with a history of gastrointestinal disease (ulcerative colitis, Grohn disease) because the disease may be worse. Hemorrhage, ulcers, or gastrointestinal perforation can be reported at all NSAIDs at any time during the treatment process, with or without warning symptoms or history of serious digestive tract complications.

The risk of bleeding, ulcers or gastrointestinal perforation is higher when increasing the dose of NSAID, in patients with a history of gastrointestinal ulcer, especially if there are complications of hemorrhage or gastrointestinal perforation, and in the elderly. These patients should be treated with the lowest dose.

Patients with a history of gastrointestinal poisoning, especially the elderly, should report any abdominal abdominal symptoms (especially gastrointestinal bleeding), especially in the early stages of treatment. Be cautious in patients using simultaneously with drugs that increase the risk of ulcerative or hemorrhage such as oral corticosteroids, anticoagulants such as warfarin, selective reabsorption inhibitors serotonin or platelet anti -platelets such as aspirin. When bleeding or digestive ulcers occur in patients taking ibuprofen, treatment should be stopped.

Serious reactions on the skin, some fatal causes include flaking dermatitis, Stevens-Johnson syndrome and poisoned epidermal necrosis. Introduce this reaction early during treatment, onset the reaction occurred in the first month of treatment in most cases. Ibuprofen should be stopped when there are the first signs of the skin rash, mucosal damage or any signs of hypersensitivity.

Dehydration

There is a risk of kidney failure in dehydration.

This drug contains

methyl paraben and propyl paraben: can cause allergies (can react late). Glucose-Galactose or a deficiency of Sucrase-Isomaltase should not take this medication.

The ability to drive and operate machinery

do not assume that Ibraf oral medication will interfere with the ability to drive and operate machinery at the recommended dose and treatment time.

During pregnancy

Although no teratogenic effect is proven in animal experiments, the use of ibuprofen, if possible, should be avoided in the first 6 months of pregnancy. During the last three months of pregnancy, ibuprofen is contraindicated because the risk of early fetal arteriosclerosis and can cause persistent pulmonary hypertension. Labor may be delayed and the time increases along with increasing bleeding trends in both mother and child.

The period of breastfeeding

In limited studies, ibuprofen appears in breast milk at very low concentrations and is not likely to adversely affect nursing babies.

Drug interaction

aspirin

Unless low -dose aspirin indicators (no more than 75 mg per day), if not this may increase the risk of side effects of the drug. Experimental data shows that ibuprofen can inhibit the effects of low -dose aspirin on platelets when used simultaneously. However, data limitations and uncertainty related to extracting ex-vivo data for clinical situations show that it is impossible to make a certain conclusion for regular use of ibuprofen, and there is no clinical significance that is considered to be capable of using ibuprofen occasionally.

Other NSAIDs include selective substances Cycloxygenase-2

Avoid using two or more NSAIDs at the same time because it may increase the risk of unwanted effects.

Be cautious when using ibuprofen in combination with

Anticoagulant: NSAID can increase the effects of anticoagulants, such as warfarin. Diuretics can increase the risk of kidney toxicity of NSAID. Increasing plasma glycosid concentration. Use Mifepriston because it can reduce the effectiveness of Mifepriston. There is evidence that increases the risk of joint bleeding and hematoma in people with HIV -infected bleeding diseases simultaneously using zidovudin and ibuprofen. Patients taking NSAID and Quinolones may increase the risk of seizures.

Mutuality

Due to the absence of studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

Store at temperatures below 30 ° C, in a dry place, avoid light.

Other drugs

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