Ihybes 300 Agimexpharm Treatment treatment of arterial hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Irbesartan

Ingredient

Composition information	Content
Irbesartan	300mg

Uses

Indications

Ihybes 300mg drug indicated in the following cases:

Definitely arterial hypertension, especially for cases of using enzyme inhibitors, cough and to reduce the risk of stroke in people with left ventricular hypertrophy. Angiotensin II TYP AT1.

Irbesartan inhibits the physiological effects of angiotensin-II, including the effect of secretion of aldosteron and vasoconstriction, due to the selective inhibition of AT1 receptors of Angiotensin II in many tissues, including adrenal and smooth muscle walls.

When taking Irbesartan with the recommended dose of blood potassium concentration does not change much unless kidney failure and/or heart failure.

Medications that lower blood pressure but the heart frequency changes very little. Hypotension effect depends on the dose and tends to not lower when taking a dose higher than 300 mg/time per day.

Maximum lower blood pressure for 3-6 hours after drinking. Anti -hypertension effect maintained at least 24 hours.

Anti -hypertension effect is manifested within 1-2 weeks, maximum efficiency achieved within 4-6 weeks from the beginning of treatment and maintenance when long -term treatment.

If the blood pressure stops gradually returning to the original value, but there is no sudden serious illness when stopping the drug.

Dynamic pharmacokinetics

absorption

After drinking, Irbesartan is quickly absorbed through the gastrointestinal tract with bioavailability of 60-80%.

Food does not change much of the bioavailability of the drug.

Peak concentration in plasma is about 1-2 hours after 1 dose.

The concentration of medication in the blood reaches a stable balance after 3 days of taking medicine.

distribution

The ratio of plasma protein is about 96%.

The distribution of the drug is about 53-93 liters.

transformation

Irbesartan is partially metabolized in the liver mainly by Cytochrom P450 ISOENZYM CYP 2C9 and possibly by both in conclusion with glucuronic acid.

Metabolic products are not active.

Elimination

Irbesartan and metabolic substances are eliminated through bile and urine, after taking about 20% of the exhaust drug in urine in the form of metabolism and less than 2% in non -metabolic.

Half of the half-life is 11-15 hours.

Before taking Ihybes 300 Agimexpharm Treatment treatment of arterial hypertension (3 blisters x 10 tablets)

How to use

Ihybes 300mg pills in the form of oral film, oral, medication can be taken during, before or after meals.

Dosage

The dose of Irbesartan is adjusted for each patient based on clinical response.

ihybes 300 indicates the following cases:

In the treatment of hypertension: For patients who do not control blood pressure at the dose of 150mg/1 time/day, the dose of 300mg/daily. Can be combined with other high blood pressure treatments. Especially when combined with diuretics such as hydrochlorothiazid has shown to increase the effect of Irbesartan.

In the treatment of kidney disease in people with diabetes Typ 2 with hypertension: Using maintenance dose 300mg/1 time/day (in patients who have started the starting dose 150mg/1 time/day).

Renal failure: No dose adjustment in people with renal impairment. Do not use this medication in patients with dialysis (due to the starting dose of 75mg/day).

Hematoma: When a decrease in blood volume or dehydration and salt, these phenomena should be overcome before using Irbesartan.

Hepatic failure: No dose adjustment for patients with mild and medium liver failure. There is no clinical experience for patients with severe liver failure.

Children: Not yet determined in terms of safety and effectiveness of Irbesartan in children.

Dosage should be adjusted after 1-2 months if the blood pressure is not controlled. May need treatment for many months to control the blood pressure well.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In case of overdose, clinical symptoms are likely to occur, hypotension and tachycardia; Slow heart rate can also occur.

Handling: There is no specific measure in the treatment of overdose with Irbesartan. Patients should be closely monitored, treated symptoms and support. Proposal proposals include vomiting and/or gastric wash, using activated carbon. Irbesartan cannot be removed by dialysis.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects when using Ihybes 300mg that you may encounter.

Unwanted effects caused by Irbesartan are generally light and transient.

Common, ADR> 1/100:

Dizziness. Hemorrhage drops can occur especially in patients with hypoglycemia (as when the patient is taking high doses of dosage).

skin rash, urticaria, itching, angioedema, liver enzyme.

Cough, respiratory disorders, back pain, digestive disorders, fatigue, neutropenia.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ihybes 300mg contraindications in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Caution when using

reducing blood volume:

There may be symptomic hypotension, especially after taking the first dose, in patients with blood volume reduced such as salt loss and water due to strong diuretic groups, salt -limiting diet, diarrhea or vomiting.

Kidney artery stenosis:

There is a risk of increasing severe hypotension and renal failure when the patient has narrowed renal artery narrowing on both sides or artery stenosis of a function that is treated with drugs that act on the renin-angiotensin-aldosterone system.

kidney failure and kidney transplantation:

When taking Irbesartan for patients with renal impairment, it is necessary to regularly check the concentration of potassium, creatinine in serum.

Hyperbonemia:

may experience hyperkalemia when using Irbesartan, especially those with heart function, poor kidneys. Avoid using Irbesartan simultaneously with potassium diuretics.

Micro valve stenosis and aortic valve stenosis, hypertrophic cardiomyopathy:

Particularly cautious for patients with mitral stenosis or aortic valve stenosis, or hypertrophic cardiomyopathy.

Increase Aldosteron Tien Phat:

It is not recommended to use Irbesartan.

Used for pregnant and lactating women

Pregnancy: Contraindications to use this medication for pregnant women. In the first 3 months of pregnancy contraindicated due to caution. In the middle 3 months or the last 3 months of pregnancy may affect the growth and development of the fetus or have adverse effects on the fetus.

Breastfeeding period: Contraindications for Ihybes 300 for breastfeeding women.

The effect of drugs when driving and operating machinery

Caution should be cautious when driving or operating machinery because it may occur dizzy and tired during treatment with this drug.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

For other anti -hypertension drugs: Other anti -hypertension drugs may increase the hypotension of Irbesartan; However, Irbesartan can still be combined with other anti -hypertension drugs, such as beta blockers, calcium blockers or thiazide diuretics. An advance treatment with high doses of diuretics can create a decrease in blood volume and the risk of hypotension when using I

Potassium supplements or potassium diuretics: Concomitance of this drug with potassium diuretics or potassium supplements may increase potassium concentration.

Lithi: Increasing serum and recovery lithium concentration has been reported when combined with transferred enzyme inhibitors. Need to carefully monitor serum lithium concentration if this combination is necessary.

Other interactive information: Digoxin's pharmacokinetics does not change when used in combination with 150mg Irbesartan in healthy people.

Irbesartan pharmacokinetics are not changed when combined with hydrochlorothiazid.

Irbesartan is metabolized by Cytochrom P450, so the interaction may occur when used with drugs on this enzyme.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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