IIBAD 400 GLOMED Pain relief caused by flu, colds, rheumatoid arthritis (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Ibuprofen
Indication Dysmenorrhea, rheumatism, back pain, joint inflammation, arthritis, body aches
Contraindication Hepatic failure, kidney failure, peptic ulcer, drug allergies

Ingredient

Composition information	Content
Ibuprofen	400mg

Uses

Indications

Ibi 400 mg drug is indicated in the following cases:

Mild pain due to the flu, common colds, sore throat, headache, migraine, postoperative pain, toothache, dysmenorrhea, back pain, muscle pain, muscle inflammation, mild pain due to arthritis, and temporary fever. anti -inflammatory steroids (NSAID). It contains pisobutyl acid derivatives of propionic acid. Ibuprofen has anti -inflammatory, analgesic and antipyretic effects. Anti -inflammatory effects can be compared to acetylsalicylic acid and indometacin. The pharmacological effect of ibuprofen may be related to the ability to inhibit the synthesis of prostaglandin. Ibuprofen extends the bleeding time through the inhibition of platelet aggregation.

Pharmacokinetics

absorption

ibuprofen is quickly absorbed from the digestive tract with 80 - 90% of bioavailability. Peak concentration in serum reaches 1-2 hours after drinking.

If used at the same meal, the peak concentration in the serum is lower and achieved slower than when not eating. Food does not significantly affect full bioavailability.

Distribution

ibuprofen is strongly connected to plasma proteins (99%). Ibuprofen has a small distribution, about 0.12 - 0.2 l/kg in adults.

Metabolism

ibuprofen is rapidly metabolized in the liver via cytochrome P450, mainly CYP2C9, forming two initial metabolites inactivated, 2 - Hydroxyibprofen and 3 - carboxyibuibprofen. After taking the medication, nearly 90% of the ibuprofen oral dose can be seen in the urine in the form of oxidation and glucuronic complex. Very few ibuprofen are eliminated in the urine in constant form.

Elimination

The elimination through the kidneys is both fast and completely completely. The sale time is about 2 hours. Eliminating ibuprofen actually completed 24 hours after the last dose.

Before taking IIBAD 400 GLOMED Pain relief caused by flu, colds, rheumatoid arthritis (10 blisters x 10 tablets)

How to use

Should take medicine immediately after meals.

Dosage

Adults

Mild pain and fever, dysmenorrhea: 1 tablet/time, taken pills from 4 to 6 hours apart. Do not drink more than 3 tablets/day.

rheumatoid arthritis, osteoarthritis: 1 - 2 capsules/time, do not drink more than 6 tablets/day.

Children over 12 years

Maximum of 40 mg/kg of weight per day in the treatment of teenage rheumatoid arthritis.

What to do when overdose?

Symptoms

Ibuprofen overdose symptoms may include drowsiness, headache, abdominal pain, shortness of breath, nausea, vomiting, arrhythmia, kidney failure, hypotension, coma.

Handling

Mainly treat symptoms and support. There is no specific antidote for ibuprofen overdose.

Make the drug easy to eliminate by gastric lavage, vomiting, diuretic and active carbon drink.

If severe, absorbing blood or blood transfusion.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ibiD 400 mg, you may experience unwanted effects (ADR).

Often disorders or gastrointestinal bleeding, stomach ulcers, indigestion, discomfort or abdominal pain, epigastric pain, heartburn, nausea.

Other symptoms include: headache, dizziness, suspense, weakness, insomnia, tinnitus, blurred vision, skin rash, itching, edema.

Risk of cardiovascular thrombosis (see more warning and caution).

Stop using and consulting your doctor if: Abnormal new signs, pain symptoms do not improve within 10 days or fever does not improve within 3 days, migraines do not decrease or become worse after taking the first dose.

Instructions for handling ADR

Notify the doctor with unwanted effects when taking the drug.

Warnings

Contraindicated

IIBAD 400 mg contraindicated for the following cases:

Hypersensitivity to the ingredients of the drug.

Be cautious when using

The drug contains ibuprofen

Do not use with any other drugs containing ibuprofen.

Heart thrombosis

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms.

Patients need to be warned about the symptoms of serious cardiovascular events and need to see a doctor as soon as these symptoms appear.

To minimize the risk of adverse events, IIBE 400 is needed at the lowest daily daily dose in the shortest possible time.

Consult your doctor before taking

Consult your doctor before use in the following cases: asthma, bronchospasm, cardiovascular disease, history or have stomach ulcers - duodenum, stomach bleeding, bleeding disorders, deficiency of endogenous blood clotting factors, liver failure or kidney failure, cirrhosis, children under 12 years old, elderly.

pregnancy or breastfeeding

consult a doctor before use. In particular, Ibuprofen is not used for the last 3 months of pregnancy unless the doctor is prescribed, because the drug can be harmful to the child who has not been born or causes complications during birth.

The ability to drive and operate machinery

The drug can make you dizzy or sleepy. Do not drive, use machinery or conduct any activity that needs concentration until you are sure to perform these activities safely.

Drug interaction

ibuprofen increases the side effects of the quinolon group on the central nervous system and can lead to seizures.

ibuprofen increases the side effects of other nonsteroidal anti -inflammatory drugs.

Simultaneous use of ibuprofen with corticosteroids increases the risk of bleeding and stomach ulcers.

ibuprofen increases the levels of lithium, digoxin, methotrexate and heart glycosides in plasma, thus increasing the toxicity of these drugs.

ibuprofen increases the effects of oral anticoagulants.

Risk of increased kidney toxicity when using ibuprofen simultaneously with enzyme inhibitors Angiotensin, Ciclosporin, tacrolimus, Furosemid or other diuretics.

Musrophic globin and renal failure increase when using ibuprofen simultaneously with ciprofibrat.

ibuprofen can reduce the protection effect of aspirin.

The toxicity of Baclofen can increase when starting to use ibuprofen.

Storage

Leave in a dry place, avoid light, the temperature does not exceed 30 ° C.

Expiry date: 36 months from the date of production.

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